Zhenhua Feng
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View article: MXene-Mediated Nanocarrier Delivery Enhances the Chondroprotective Effects of Quercetin in Experimental Osteoarthritis
MXene-Mediated Nanocarrier Delivery Enhances the Chondroprotective Effects of Quercetin in Experimental Osteoarthritis Open
These findings suggest that MXene can serve as a biocompatible carrier to improve quercetin delivery in osteoarthritis models, supporting its potential for further preclinical evaluation.
View article: Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration
Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration Open
View article: DASViT: Differentiable Architecture Search for Vision Transformer
DASViT: Differentiable Architecture Search for Vision Transformer Open
Designing effective neural networks is a cornerstone of deep learning, and Neural Architecture Search (NAS) has emerged as a powerful tool for automating this process. Among the existing NAS approaches, Differentiable Architecture Search (…
View article: Biomechanical Advantages of Novel Duet Screws Plus Bilateral Satellite Rods Fixation in the Correction Surgery for Adult Spinal Deformity
Biomechanical Advantages of Novel Duet Screws Plus Bilateral Satellite Rods Fixation in the Correction Surgery for Adult Spinal Deformity Open
Purpose Adult spinal deformity (ASD) patients undergoing pedicle subtraction osteotomy (PSO) with long fusion to the pelvis have a high risk of rod failure at the PSO level or adjacent areas. This study aimed to investigate the biomechanic…
View article: Upregulated CEMIP promotes intervertebral disc degeneration via AP‐1‐mediated change in chromatin accessibility
Upregulated CEMIP promotes intervertebral disc degeneration via AP‐1‐mediated change in chromatin accessibility Open
Background Intervertebral disc degeneration (IDD), a chronic and multifactorial skeletal disorder, is the primary cause of low back pain. It results in reduced disc height and nucleus pulposus hydration due to proteoglycan loss and nucleus…
View article: Serum alkaline phosphatase/creatinine ratio serving as a screening tool for low lumbar bone mineral density in patients with degenerative lumbar scoliosis
Serum alkaline phosphatase/creatinine ratio serving as a screening tool for low lumbar bone mineral density in patients with degenerative lumbar scoliosis Open
OI correlated significantly with lumbar BMD and HU value. Logistic regression and RCS analysis demonstrated that OI could serve as a simple, economical, and effective screening tool for low lumbar BMD in DLS patients, with its predictive a…
View article: Offline Reinforcement Learning using Human-Aligned Reward Labeling for Autonomous Emergency Braking in Occluded Pedestrian Crossing
Offline Reinforcement Learning using Human-Aligned Reward Labeling for Autonomous Emergency Braking in Occluded Pedestrian Crossing Open
Effective leveraging of real-world driving datasets is crucial for enhancing the training of autonomous driving systems. While Offline Reinforcement Learning enables the training of autonomous vehicles using such data, most available datas…
View article: Diagnostic efficacy of nerve root sedimentation sign in post-lumbar interbody fusion patients: an imaging evaluation and modification
Diagnostic efficacy of nerve root sedimentation sign in post-lumbar interbody fusion patients: an imaging evaluation and modification Open
View article: Learning Structure-Supporting Dependencies via Keypoint Interactive Transformer for General Mammal Pose Estimation
Learning Structure-Supporting Dependencies via Keypoint Interactive Transformer for General Mammal Pose Estimation Open
General mammal pose estimation is an important and challenging task in computer vision, which is essential for understanding mammal behaviour in real-world applications. However, existing studies are at their preliminary research stage, wh…
View article: Distributed OPGW abnormal vibration monitoring and forewarning based on LSTM
Distributed OPGW abnormal vibration monitoring and forewarning based on LSTM Open
Analyzing and predicting abnormal vibrations in optical fiber composite overhead ground wire (OPGW) transmission lines accurately is a challenging task. This paper proposes a distributed monitoring and forewarning method for OPGW abnormal …
View article: Short-Term Stock Price Forecasting Using ARIMA: A Case Study on Apple and Amazon
Short-Term Stock Price Forecasting Using ARIMA: A Case Study on Apple and Amazon Open
View article: SimVG: A Simple Framework for Visual Grounding with Decoupled Multi-modal Fusion
SimVG: A Simple Framework for Visual Grounding with Decoupled Multi-modal Fusion Open
Visual grounding is a common vision task that involves grounding descriptive sentences to the corresponding regions of an image. Most existing methods use independent image-text encoding and apply complex hand-crafted modules or encoder-de…
View article: Probabilistically Aligned View-unaligned Clustering with Adaptive Template Selection
Probabilistically Aligned View-unaligned Clustering with Adaptive Template Selection Open
In most existing multi-view modeling scenarios, cross-view correspondence (CVC) between instances of the same target from different views, like paired image-text data, is a crucial prerequisite for effortlessly deriving a consistent repres…
View article: Nuclear receptor <scp>Rev‐erbα</scp> alleviates intervertebral disc degeneration by recruiting <scp>NCoR</scp>–<scp>HDAC3</scp> co‐repressor and inhibiting <scp>NLRP3</scp> inflammasome
Nuclear receptor <span>Rev‐erbα</span> alleviates intervertebral disc degeneration by recruiting <span>NCoR</span>–<span>HDAC3</span> co‐repressor and inhibiting <span>NLRP3</span> inflammasome Open
Intervertebral discs (IVDs) are rhythmic tissues that experience daily low‐load recovery. Notably, aging and abnormal mechanical stress predispose IVDs to degeneration due to dysrhythmia‐induced disordered metabolism. Meanwhile, Rev‐erbα a…
View article: Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
View article: An agent-based persuasion model using emotion-driven concession and multi-objective optimization
An agent-based persuasion model using emotion-driven concession and multi-objective optimization Open
Multi-attribute negotiation is essentially a multi-objective optimization (MOO) problem, where models of agent-based emotional persuasion (EP) can exhibit characteristics of anthropomorphism. This paper proposes a novel EP model by fusing …
View article: Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches
Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches Open
View article: DailyMAE: Towards Pretraining Masked Autoencoders in One Day
DailyMAE: Towards Pretraining Masked Autoencoders in One Day Open
Recently, masked image modeling (MIM), an important self-supervised learning (SSL) method, has drawn attention for its effectiveness in learning data representation from unlabeled data. Numerous studies underscore the advantages of MIM, hi…
View article: FATP2 regulates osteoclastogenesis by increasing lipid metabolism and ROS production
FATP2 regulates osteoclastogenesis by increasing lipid metabolism and ROS production Open
Lipid metabolism plays a crucial role in maintaining bone homeostasis, particularly in osteoclasts (OCs) formation. Here, we found that the expression level of FATP2, a transporter for long-chain and very-long-chain fatty acids, was signif…
View article: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
View article: EIF4A3 induced CircCHD7 promote osteosarcoma progression by sponge miR-608 and regulated FZD4/MMP2 expression through Wnt/β-catenin pathway
EIF4A3 induced CircCHD7 promote osteosarcoma progression by sponge miR-608 and regulated FZD4/MMP2 expression through Wnt/β-catenin pathway Open
Background Osteosarcoma is a malignant tumor that tends to occur in adolescents. In recent years, surgical treatment has reduced mortality rates in patients with osteosarcoma. However, many patients still die of osteosarcoma, and further s…
View article: SCD-Net: Spatiotemporal Clues Disentanglement Network for Self-supervised Skeleton-based Action Recognition
SCD-Net: Spatiotemporal Clues Disentanglement Network for Self-supervised Skeleton-based Action Recognition Open
Contrastive learning has achieved great success in skeleton-based action recognition. However, most existing approaches encode the skeleton sequences as entangled spatiotemporal representations and confine the contrasts to the same level o…
View article: Masked Momentum Contrastive Learning for Zero-shot Semantic Understanding
Masked Momentum Contrastive Learning for Zero-shot Semantic Understanding Open
Self-supervised pretraining (SSP) has emerged as a popular technique in machine learning, enabling the extraction of meaningful feature representations without labelled data. In the realm of computer vision, pretrained vision transformers …
View article: More Prevalent and Severe Low Bone-Mineral Density in Boys with Severe Adolescent Idiopathic Scoliosis Than Girls: A Retrospective Study of 798 Surgical Patients
More Prevalent and Severe Low Bone-Mineral Density in Boys with Severe Adolescent Idiopathic Scoliosis Than Girls: A Retrospective Study of 798 Surgical Patients Open
Introduction: A total of 0.1–0.8% of AIS patients progress to severe stages without clear mechanisms, and AIS girls are more prone to curve progression than boys. Recent studies suggest that AIS girls have systemic and persistent low bone-…
View article: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice
Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice Open
Background and Purpose: Overactivated osteoclasts disrupt the mineral homeostasis of bone, inducing osteoporosis. Despite the rapid development of pharmacological therapy in osteoporosis, a safer and more effective treatment remains to be …
View article: CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post‐translational modification
CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post‐translational modification Open
Background Circular RNAs (CircRNAs) are important and have different roles in disease progression. Herein, we aim to elucidate the roles of a novel CircRNA (CircZSWIM6) which is upregulated in ageing chondrocytes. Methods We verified the r…
View article: Spinal cord conduits for spinal cord injury regeneration
Spinal cord conduits for spinal cord injury regeneration Open
Spinal cord injury (SCI), which causes irreversible damage in both sensory and motor function, is considered an insurmountable challenge in the field of medicine. The previous researchers have developed many kinds of biomaterials for SCI, …
View article: Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway
Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway Open
Emerging evidence indicated circadian clock gene Rev-erbα was involved in cartilage metabolism, however the contribution of Rev-erbα to growth plate chondrogenesis remains unknown. Here, we found that Rev-erbα exhibited the spatiotemporal …
View article: Identification of a novel splicing mutation and genotype–phenotype correlations in rare PLS3-related childhood-onset osteoporosis
Identification of a novel splicing mutation and genotype–phenotype correlations in rare PLS3-related childhood-onset osteoporosis Open
Background X-linked early-onset osteoporosis, caused by mutations in plastin3 (PLS3), is an extremely rare disease characterized by low bone mineral density (BMD) and recurrent osteoporotic fractures. There is limited information on geneti…
View article: Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2 Open