Zhi‐Ling Yu
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View article: Cortical morphometric similarity patterns and molecular signatures across ischemic stroke recovery
Cortical morphometric similarity patterns and molecular signatures across ischemic stroke recovery Open
Background Ischemic stroke is associated with widespread and dynamic brain structural alterations, but the relationship between these changes and underlying molecular signatures across different post-stroke stages remains unclear. Therefor…
View article: Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD
Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD Open
Curcumin is renowned for anti-inflammatory, antioxidant and hepatoprotective effects, and has been implicated in the amelioration of obesity and diabetes. Notwithstanding its considerable therapeutic potential, the clinical utility of curc…
View article: Quantitative evaluation of therapeutic effect of silver needle thermal conduction therapy on myofascial trigger point
Quantitative evaluation of therapeutic effect of silver needle thermal conduction therapy on myofascial trigger point Open
Background In clinical practice, silver needle thermal conduction therapy has a definite effect on myofascial pain syndrome (MPS). However, there is a lack of objective evidence to evaluate the efficacy of this therapy. This study aimed to…
View article: Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics
Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics Open
RNAi therapeutics can potentially address undruggable diseases. However, their full potential is stymied by delivery challenges. An siRNA delivery platform by remodeling the human U4 small nuclear ribonucleoprotein complex (snRNP) is devel…
View article: Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism‐Like Behaviors in a Valproic Acid Induced Male Mouse Model
Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism‐Like Behaviors in a Valproic Acid Induced Male Mouse Model Open
This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism‐like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (…
View article: The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity Open
Introduction Cisplatin is extensively employed in the treatment of multiple solid malignant tumors. Nevertheless, side effects such as cisplatin-induced ototoxicity (CIO) pose obstacles to tumor therapy.The important natural product chiisa…
View article: Dietary supplementation with milk‐derived <i>Bifidobacterium animalis</i> subsp<i>. lactis</i> relieves colitis‐linked reproductive disorders via gut‐testis axis
Dietary supplementation with milk‐derived <i>Bifidobacterium animalis</i> subsp<i>. lactis</i> relieves colitis‐linked reproductive disorders via gut‐testis axis Open
Rapid urbanization, medication, and modern dietary patterns are the main challenges leading to impaired fertility, with a lack of effective therapies. Emerging evidence suggests that reproductive disorders may be closely associated with in…
View article: The Impacts of the National Innovative City Pilot Policy on Employment––A Quasi-Natural Experiment from China
The Impacts of the National Innovative City Pilot Policy on Employment––A Quasi-Natural Experiment from China Open
View article: Experimental and Mechanistic Study on Liquid-Liquid Equilibrium for the Separation of Cyclohexane and Ethyl Acetate Using Imidazolium Ionic Liquids
Experimental and Mechanistic Study on Liquid-Liquid Equilibrium for the Separation of Cyclohexane and Ethyl Acetate Using Imidazolium Ionic Liquids Open
View article: Harnessing monocyte dynamics for treatment of multiple sclerosis; insights from experimental model studies
Harnessing monocyte dynamics for treatment of multiple sclerosis; insights from experimental model studies Open
Monocytes are central to the innate immune system’s response to infection or injury. In murine, these cells are classified into distinct subsets: classical monocytes, defined by elevated Ly6C expression (Ly6Chi), intermediate monocytes (Ly…
View article: Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation
Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation Open
PRF attenuated microglial activation by upregulating MG53 to inhibit ERS, resulting in the alleviation of NP in CCI rats.
View article: Symptoms can predict COVID-19 pneumonia in patients infected with SARS-CoV-2 Omicron variants
Symptoms can predict COVID-19 pneumonia in patients infected with SARS-CoV-2 Omicron variants Open
View article: Attenuation of arsenic-induced gut injury in mice by sulfated glycosaminoglycan from swim bladder <i>via</i> regulation of gut microbiota, metabolites, and intestinal barrier integrity
Attenuation of arsenic-induced gut injury in mice by sulfated glycosaminoglycan from swim bladder <i>via</i> regulation of gut microbiota, metabolites, and intestinal barrier integrity Open
Arsenic, a known environmental carcinogen, disrupts intestinal homeostasis, posing a significant threat to human health. Mitigating its toxic effects is crucial, and this study explores the potential of swim bladder sulfated glycosaminogly…
View article: Sea bass (<i>Lateolabrax maculatus</i>) exerts anti‐ulcerative colitis effects through gut microbiota modulation
Sea bass (<i>Lateolabrax maculatus</i>) exerts anti‐ulcerative colitis effects through gut microbiota modulation Open
Traditional Chinese medicinal books have noted that sea bass ( Lateolabrax maculatus ) may effectively manage inflammation‐linked conditions. The folk use of sea bass during pregnancy as nutritional care is also popular in China. However, …
View article: A novel model for Platelets Dynamics: a pragmatic systems approach to characterize thrombocytopenia across multiple compounds and drug classes
A novel model for Platelets Dynamics: a pragmatic systems approach to characterize thrombocytopenia across multiple compounds and drug classes Open
View article: The Aqueous Extract of Rubus Corchorifolius L. Fruit Supplementation Ameliorates Hepatic Steatosis and Apoptosis in Mafld Through Ampk/Pparα Signaling Pathway
The Aqueous Extract of Rubus Corchorifolius L. Fruit Supplementation Ameliorates Hepatic Steatosis and Apoptosis in Mafld Through Ampk/Pparα Signaling Pathway Open
View article: Study on Vapor-Liquid Equilibrium for the Separation of Ethyl Acetate and Isopropanol Azeotrope Using Phosphonium-Based Ionic Liquids
Study on Vapor-Liquid Equilibrium for the Separation of Ethyl Acetate and Isopropanol Azeotrope Using Phosphonium-Based Ionic Liquids Open
View article: Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells
Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells Open
Peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1 (CPT1) are important targets of lipid metabolism regulation for nonalcoholic fatty liver disease (NAFLD) therapy. In the present study, a set of …
View article: Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2
Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2 Open
Preclinical and clinical studies have demonstrated the synergistic effect of microtubule-targeting agents in combination with Janus kinase 2 (JAK2) inhibitors, prompting the development of single agents with enhanced therapeutic efficacy b…
View article: Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy
Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy Open
The administration of XZTZ decoction demonstrates a protective effect on the livers of NAFLD mice by inhibiting lipid accumulation and reducing hepatocyte inflammatory damage. This protective effect is mediated by the upregulation of I.val…
View article: Exploration of the Shared Gene and Molecular Mechanisms between Breast Cancer and Non-alcoholic Fatty Liver Disease Based on Available Public Transcriptome Sequencing Data
Exploration of the Shared Gene and Molecular Mechanisms between Breast Cancer and Non-alcoholic Fatty Liver Disease Based on Available Public Transcriptome Sequencing Data Open
Background: Breast cancer (BC) is one of the most common malignant tumors in women; its etiology is unknown. A meta-analysis demonstrates a close association between non-alcoholic fatty liver disease (NAFLD) and BC. However, the mechanism …
View article: Editorial review on Vol. 7 No. 1
Editorial review on Vol. 7 No. 1 Open
The articles in this issue (Volume 7 Issue 1 of Trends in Immunotherapy) are mainly review-type articles, and the sources of the articles are mainly scholars in the medical field from all over the world.The content includes research on imm…
View article: Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata
Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata Open
Asthma is a chronic inflammatory disease characterized by airway hypersensitivity and remodeling. The current treatments provide only short-term benefits and may have undesirable side effects; thus, alternative or supplementary therapy is …
View article: A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1
A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1 Open
GPHE protects against ethanol-induced liver injury, and this effect of GPHE is associated with regulation of the MKP1/MAPK pathway. This study provides pharmacological justifications for the use of GPH in treating liver injury, and suggest…
View article: Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR
Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR Open
Cellular mesenchymal–epithelial transition factor (c-Met), an oncogenic transmembrane receptor tyrosine kinase (RTK), plays an essential role in cell proliferation during embryo development and liver regeneration. Thioredoxin reductase (Tr…
View article: Arabidopsis DXO1 activates RNMT1 to methylate the mRNA guanosine cap
Arabidopsis DXO1 activates RNMT1 to methylate the mRNA guanosine cap Open
Eukaryotic messenger RNA (mRNA) typically contains a methylated guanosine (m 7 G) cap, which mediates major steps of mRNA metabolism. Recently, some RNAs in both prokaryotic and eukaryotic organisms have been found to carry a non-canonical…
View article: An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing Open
Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (…
View article: Clinicopathologic factors linked to oncologic outcomes for renal cell carcinoma with sarcomatoid dedifferentiation: A PRISMA-compliant systematic review and meta-analysis
Clinicopathologic factors linked to oncologic outcomes for renal cell carcinoma with sarcomatoid dedifferentiation: A PRISMA-compliant systematic review and meta-analysis Open
Background There are still differences in the prognostic factors of renal cell carcinoma with sarcomatoid dedifferentiation (sRCC). The aim of this study was to evaluate important predictors of survival in patients with sRCC. Patients and …
View article: Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis
Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis Open
View article: Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of <i>Qi Wei Wan</i> Formula for Treating Non-Small Cell Lung Carcinoma
Network Pharmacology Analysis of Bioactive Components and Mechanisms of Action of <i>Qi Wei Wan</i> Formula for Treating Non-Small Cell Lung Carcinoma Open
Astragali Radix (AR) and Schisandrae chinensis Fructus (SCF) have been used individually and in traditional Chinese medicine (TCM) formulas for treating non-small cell lung carcinoma (NSCLC). Qi Wei Wan (QWW), a 2-herb TCM formula composed…