Zhijun Kang
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View article: Electron Beam Modification of Solid Polymer Electrolytes for Solid‐State Lithium Metal Batteries
Electron Beam Modification of Solid Polymer Electrolytes for Solid‐State Lithium Metal Batteries Open
Solid polymer electrolytes (SPEs) offer flexibility and processability but suffer from low ionic conductivity and inadequate mechanical strength. Here, a facile, solvent‐free electron beam (EB) irradiation method is introduced to modify po…
View article: Engineered long-acting Irisin-albumin binding domain fusion protein for enhanced anti-inflammatory efficacy in lipopolysaccharide-induced systemic inflammation
Engineered long-acting Irisin-albumin binding domain fusion protein for enhanced anti-inflammatory efficacy in lipopolysaccharide-induced systemic inflammation Open
Irisin is a peptide hormone with notable anti-inflammatory and metabolic regulatory effects but has limited clinical utility due to its extremely short plasma half-life (< 1 h). In this study, we engineered an albumin-binding domain (ABD)-…
View article: Dynamic Response and Failure Mode of Reinforced Concrete Beams Subjected to Impact
Dynamic Response and Failure Mode of Reinforced Concrete Beams Subjected to Impact Open
The dynamic behavior of reinforced concrete (RC) beams under impact loads is highly complex. In this work, the failure modes, impact force, displacement, and internal force of RC beams under impact loads were studied in detail with differe…
View article: Clinical Patterns of Dyslipidemia in Patients With Initial-Treatment and Drug-Naïve Schizophrenia
Clinical Patterns of Dyslipidemia in Patients With Initial-Treatment and Drug-Naïve Schizophrenia Open
Background: Schizophrenia (SCZ) is a common, chronic, severe mental disorder that is often accompanied by dyslipidemia and linked to decreased life expectancy. The prevalence of dyslipidemia among initial-treatment and drug-naïve (ITDN) pa…
View article: Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses
Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses Open
The persistent threat posed by SARS-CoV-2-related coronaviruses (SC2r-CoVs) in wildlife highlights the risk of zoonotic transmission. Cross-species infectivity is predominantly determined by spike (S) character and S-mediated cell entry. I…
View article: PC3D-YOLO: An Enhanced Multi-Scale Network for Crack Detection in Precast Concrete Components
PC3D-YOLO: An Enhanced Multi-Scale Network for Crack Detection in Precast Concrete Components Open
Crack detection in precast concrete components aims to achieve precise extraction of crack features within complex image backgrounds. Current computer vision-based methods typically conduct limited local searches at a single scale, constra…
View article: Multifunctional COF Colloid Regulates Anion Coordination in Solid Poly(Ionic Liquid)‐Based Electrolyte for Lithium Metal Batteries
Multifunctional COF Colloid Regulates Anion Coordination in Solid Poly(Ionic Liquid)‐Based Electrolyte for Lithium Metal Batteries Open
The development of solid polymer electrolytes (SPEs) has been significantly impeded by two primary challenges: low ionic conductivity and the inhomogeneous deposition of lithium metal anode. Overcoming these limitations needs to reduce pol…
View article: Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies Open
Background This study aims to screen, validate novel biomarkers and develop a user-friendly online tool for the detection of colorectal cancer (CRC). Methods Multi-omics approach, comprising proteomic analysis and single-cell transcriptomi…
View article: Fatigue Driving Detection Technology: An Overview
Fatigue Driving Detection Technology: An Overview Open
In order to reduce the loss of life and property to the public caused by fatigue driving, the advantages and disadvantages of various fatigue detection methods are comprehensively analyzed based on the subjective evaluation method and obje…
View article: Young stellar objects from the LAMOST and ZTF surveys: Physical properties, classification, and light curve analysis
Young stellar objects from the LAMOST and ZTF surveys: Physical properties, classification, and light curve analysis Open
Context. The study of young stellar objects (YSOs) not only enhances our understanding of star formation and stellar evolution, but also contributes to broader areas of astrophysics, including planetary science, galactic dynamics, and astr…
View article: Design of a Vehicle Fatigue Driving Detection System Based on Multiple Signals
Design of a Vehicle Fatigue Driving Detection System Based on Multiple Signals Open
In recent years, traffic accidents have occurred frequently, and most of them are related to the level of fatigue of drivers. In order to avoid the dangers of fatigue driving, this article judges whether the driver is in a fatigued state b…
View article: Supplementary information from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Supplementary information from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Open
Supplementary Materials and Methods Supplementary References Tables S1 to S3 and legends Figures S1 to S4 and legends
View article: Supplementary information from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Supplementary information from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Open
Supplementary Materials and Methods Supplementary References Tables S1 to S3 and legends Figures S1 to S4 and legends
View article: Data from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Data from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Open
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated t…
View article: Data from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Data from Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib Open
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated t…
View article: CCDC 2191608: Experimental Crystal Structure Determination
CCDC 2191608: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Multi-disciplinary efforts to evaluate the therapeutic potential of CDK11, a novel transcription associated cyclin dependent kinase.
Multi-disciplinary efforts to evaluate the therapeutic potential of CDK11, a novel transcription associated cyclin dependent kinase. Open
Conclusions• CDK11 was identified from an in vivo functional genomics screen as a novel therapeutic target in PCAD patients.• Pharmacological inhibition with potent and selective tool compounds revealed a disconnect with genetic validation…
View article: A High Peak Power and High Beam Quality Sub-Nanosecond Nd:YVO4 Laser System at 1 kHz Repetition Rate without SRS Process
A High Peak Power and High Beam Quality Sub-Nanosecond Nd:YVO4 Laser System at 1 kHz Repetition Rate without SRS Process Open
We present a compact sub-nanosecond diode-end-pumped Nd:YVO4 laser system running at 1 kHz. A maximum output energy of 65.4 mJ without significant stimulated Raman scattering (SRS) process was obtained with a pulse duration of 600 ps, corr…
View article: Eradication of<i>ENO1</i>-deleted Glioblastoma through Collateral Lethality
Eradication of<i>ENO1</i>-deleted Glioblastoma through Collateral Lethality Open
Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We recently demonstrated that SF2312, a natural product phosphonate antibiotic, is a potent inhibitor of the glycolytic enzyme Enolase with potential utili…