Zhenjun Yu
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View article: Association Between the Dietary Index for Gut Microbiota and Frailty: Mediating Role of Body Mass Index
Association Between the Dietary Index for Gut Microbiota and Frailty: Mediating Role of Body Mass Index Open
Dietary composition and quality have been linked to the onset of frailty. Although the recently developed Dietary Index for Gut Microbiota (DI‐GM) offers a means to evaluate diet quality based on its impact on the gut microbiota, its relev…
View article: The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones
The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones Open
Background The extent of food processing significantly impacts human health, with ultra-processed foods (UPFs) linked to numerous adverse health outcomes. In contrast, research on unprocessed or minimally processed foods (MPFs) and their a…
View article: Evaluating the relationship between familial poverty, Helicobacter pylori seropositivity, and all-cause mortality in the general US population
Evaluating the relationship between familial poverty, Helicobacter pylori seropositivity, and all-cause mortality in the general US population Open
Purpose Socioeconomic inequality is closely related to the incidence of Helicobacter pylori ( H. pylori ) infection and mortality outcomes. Accordingly, this study was designed with the goal of exploring the relationship between familial p…
View article: Analysis between Helicobacter pylori infection and hepatobiliary diseases
Analysis between Helicobacter pylori infection and hepatobiliary diseases Open
Objective Helicobacter pylori ( H. pylori ) represents a significant chronic health concern, affecting approximately half of the global population. While H. pylori infection has been closely linked to numerous extradigestive diseases, the …
View article: Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure
Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure Open
The mortality of ACLF patients was determined by the number and type, but not the onset time and sequence of EHOF. Risk stratification applicable to clinical practice was established.
View article: 165P Immunosuppressive F13A1+ Mo/Mϕ in the tumor microenvironment as a hallmark for multiple primary lung cancers
165P Immunosuppressive F13A1+ Mo/Mϕ in the tumor microenvironment as a hallmark for multiple primary lung cancers Open
The increasing number of patients with multiple primary lung cancers (MPLCs) endows a rising challenge for clinical management. The tumor microenvironment (TME) has a critical role in MPLCs but its contribution to cancer onset remains uncl…
View article: Identification of a bile acid and bile salt metabolism-related lncRNA signature for predicting prognosis and treatment response in hepatocellular carcinoma
Identification of a bile acid and bile salt metabolism-related lncRNA signature for predicting prognosis and treatment response in hepatocellular carcinoma Open
View article: Clinical features and prognosis of acute-on-chronic liver failure in patients with recompensated cirrhosis
Clinical features and prognosis of acute-on-chronic liver failure in patients with recompensated cirrhosis Open
View article: The Development and Validation of a Nomogram for Predicting Cancer-Specific Survival and a Risk Stratification System for Patients with Primary Gastrointestinal Melanoma
The Development and Validation of a Nomogram for Predicting Cancer-Specific Survival and a Risk Stratification System for Patients with Primary Gastrointestinal Melanoma Open
We developed and validated a practical prediction model of cancer-specific survival and a risk stratification system for patients with primary gastrointestinal melanoma, which might be available in clinical practices.
View article: Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury
Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury Open
View article: LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway
LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway Open
Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer…
View article: STARD5 as a potential clinical target of hepatocellular carcinoma
STARD5 as a potential clinical target of hepatocellular carcinoma Open
To reveal whether STARD5 is a potential biomarker for diagnosis and prognosis of HCC. Using gene expression omnibus and the cancer genome atlas (TCGA) to screen differentially expressed genes in HCC and STARD5 was selected by LASSO algorit…
View article: Development and Validation of Nomogram for Predicting Survival of Primary Liver Cancers Using Machine Learning
Development and Validation of Nomogram for Predicting Survival of Primary Liver Cancers Using Machine Learning Open
Background and Aims Primary liver cancer (PLC) is a common malignancy with poor survival and requires long-term follow-up. Hence, nomograms need to be established to predict overall survival (OS) and cancer-specific survival (CSS) from dif…
View article: The dynamics of cell death patterns and regeneration during acute liver injury in mice
The dynamics of cell death patterns and regeneration during acute liver injury in mice Open
Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl 4 ‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death …
View article: Development of a Widely Applicable and Simple Prognostic Score for Patients with Acute-on-chronic Liver Failure
Development of a Widely Applicable and Simple Prognostic Score for Patients with Acute-on-chronic Liver Failure Open
The new ACLF prognostic score was simple, widely applicable, and had good predictive efficacy. Continuous assessments and trend of change in WASP-ACLF need to be considered, especially for intermediate-risk patients.
View article: Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma
Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma Open
Objective Hepatocellular carcinoma (HCC) is one of the most common and malignant tumors with an insidious onset, difficult early diagnosis, and limited therapy options, resulting in a poor prognosis. Cell division cycle associated 2 (CDCA2…
View article: Tim‐3 suppresses autoimmune hepatitis via the p38/MKP‐1 pathway in Th17 cells
Tim‐3 suppresses autoimmune hepatitis via the p38/MKP‐1 pathway in Th17 cells Open
T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 (Tim‐3) mediates T‐cell suppression in various autoimmune diseases, such as chronic inflammatory liver disease. However, the regulatory effect of Tim‐3 on Th17 cells in autoimmu…
View article: A dynamic prediction model for prognosis of acute-on-chronic liver failure based on the trend of clinical indicators
A dynamic prediction model for prognosis of acute-on-chronic liver failure based on the trend of clinical indicators Open
Acute-on-chronic liver failure (ACLF) is a dynamic syndrome, and sequential assessments can reflect its prognosis more accurately. Our aim was to build and validate a new scoring system to predict short-term prognosis using baseline and dy…
View article: Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis
Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis Open
Introduction The incidence of laryngeal tuberculosis has increased gradually in recent years. Laryngeal tuberculosis has strong infectivity and atypical clinical manifestations. Hence, establishing the early diagnosis of laryngeal tubercul…
View article: Performance assessment of age-adapted SOFA, qSOFA, and PELOD-2, PCIS, P-MODS for Hand, Foot and Mouth Disease
Performance assessment of age-adapted SOFA, qSOFA, and PELOD-2, PCIS, P-MODS for Hand, Foot and Mouth Disease Open
Objectives Hand, foot and mouth disease (HFMD) is a common infectious disease in children caused by intestinal virus and an important cause of child death. Early identification of critical HFMD and timely intervention are the key to reduce…
View article: Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome Open
View article: Effects of T cell immunoglobulin and mucin domain-containing molecule-3 signaling molecule on human monocyte-derived dendritic cells with hepatitis B virus surface antigen stimulation in vitro
Effects of T cell immunoglobulin and mucin domain-containing molecule-3 signaling molecule on human monocyte-derived dendritic cells with hepatitis B virus surface antigen stimulation in vitro Open
The aim of the present study was to investigate the in vitro effects of hepatitis B virus surface antigen (HBsAg) on the immune function of human monocyte-derived dendritic cells (MD‑DCs), and the moderating role of T cell immunoglobulin a…