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View article: Enhancing anti-tumour immunity through modulating dendritic cell activation by combination therapy with a novel TLR2 agonist and PD-L1 Blockade
Enhancing anti-tumour immunity through modulating dendritic cell activation by combination therapy with a novel TLR2 agonist and PD-L1 Blockade Open
Background Dendritic cells (DCs) play a predominant role in antitumor immunity. As professional antigen-presenting cells (APCs), DCs can be functionally matured by TLR2 ligand binding to enhance innate immune response and subsequent T cell…
View article: Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation
Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation Open
View article: Nickel-Catalyzed Enantioselective Reductive Vinyl-Alkynylation of Unactivated Alkenes with Bromoalkynes
Nickel-Catalyzed Enantioselective Reductive Vinyl-Alkynylation of Unactivated Alkenes with Bromoalkynes Open
View article: Protocol for Sonogashira coupling of alkynes and aryl halides via nickel catalysis
Protocol for Sonogashira coupling of alkynes and aryl halides via nickel catalysis Open
View article: Nickel-catalyzed Difluoromethylation of Alkene using Difluoroacetic Anhydride
Nickel-catalyzed Difluoromethylation of Alkene using Difluoroacetic Anhydride Open
Herein, we describe a nickel-catalyzed reductive difluoromethylation reaction of alkene using inexpensive and easy-to-handle DFAA/pyridine N-oxide reagent system. A variety of C(sp3)-CF2H containing compounds were prepared through a hydrod…
View article: Nickel-catalyzed enantioselective domino Heck/Sonogashira coupling for construction of C(sp)-C(sp) bond-substituted quaternary carbon centers
Nickel-catalyzed enantioselective domino Heck/Sonogashira coupling for construction of C(sp)-C(sp) bond-substituted quaternary carbon centers Open
View article: Synthesis of 3-thiocyanated chromones via TCCA/NH4SCN-mediated cyclization/thiocyanation of alkynyl aryl ketones
Synthesis of 3-thiocyanated chromones via TCCA/NH4SCN-mediated cyclization/thiocyanation of alkynyl aryl ketones Open
3-Thiocyanated chromones was conveniently synthesized from alkynyl aryl ketones using commercially available, inexpensive trichloroisocyanuric acid (TCCA) as oxidant and NH4SCN as thiocyanato (SCN) source. This metal-free approach is postu…
View article: CCDC 1912887: Experimental Crystal Structure Determination
CCDC 1912887: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1913074: Experimental Crystal Structure Determination
CCDC 1913074: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …