Zhenkun Lou
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View article: Targeting the Intracellular Domain of PD-L1 to Sensitize Tumors to Cytotoxic Therapy 2085
Targeting the Intracellular Domain of PD-L1 to Sensitize Tumors to Cytotoxic Therapy 2085 Open
Description The PD-L1/PD-1 receptor pathway allows cancer cells to evade immune surveillance, yet only a small percentage of patients benefit from PD-1/PD-L1 inhibitors. This limited efficacy is likely due to gaps in our understanding of P…
View article: Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer Open
Metastatic castration-resistant prostate cancer (mCRPC) progresses aggressively and resists existing therapies. Although poly(ADP-ribose) polymerase inhibitors (PARPis) benefit a subset of patients with mCRPC and BRCA1/2 deficiencies, ther…
View article: KCTD10 is a sensor for co-directional transcription–replication conflicts
KCTD10 is a sensor for co-directional transcription–replication conflicts Open
During DNA replication, the replisome must remove barriers and roadblocks including the transcription machinery1,2. Transcription-replication conflicts (TRCs) occur when there are collisions between the replisome and transcription machiner…
View article: DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers Open
CDK12 primarily functions as a transcription regulatory cyclin-dependent kinase (CDK) that controls mRNA elongation, splicing, and polyadenylation. The CDK12 gene is implicated in human cancers since it is frequently mutated and/or deleted…
View article: Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma
Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma Open
Oncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MME…
View article: Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop
Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop Open
Triple-negative breast cancer (TNBC) represents the most malignant subtype of breast cancer. The clinical application of PARP inhibitors (PARPi) is limited by the low frequency of BRCA1/2 mutations in TNBC. Here, we identified that MTAP de…
View article: The many connections of UFMylation with Alzheimer’s disease: a comprehensive review
The many connections of UFMylation with Alzheimer’s disease: a comprehensive review Open
Alzheimer’s disease (AD) is a complex neurodegenerative disorder that is characterized by the accumulation of pathologic tau and beta-amyloid proteins. UFMylation is an emerging ubiquitin-like post-translational modification that is crucia…
View article: Mono-ubiquitination of TopBP1 by PHRF1 enhances ATR activation and genomic stability
Mono-ubiquitination of TopBP1 by PHRF1 enhances ATR activation and genomic stability Open
The TopBP1-ATR axis is critical for maintaining genomic stability during DNA replication stress, yet the precise regulation of TopBP1 in replication stress responses remains poorly understood. In this study, we identified PHD and Ring Fing…
View article: The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics
The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics Open
Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well understood, the connection between chromatin remodeling and …
View article: STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance
STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance Open
The phosphorylation of histone H2A.X into γH2A.X is a crucial early event in the DNA damage response, marking DNA damage sites and initiating repair processes. While ATM kinase is traditionally recognized as the primary mediator of H2A.X p…
View article: Data from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Data from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Imatinib mesylate (IM) has revolutionized the treatment of gastrointestinal stromal tumor (GIST). However, most patients inevitably acquire IM resistance. Second- and third-line treatments exhibit modest clinical benefits with a median tim…
View article: Supplemental Materials and Methods from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplemental Materials and Methods from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplemental Materials and Methods
View article: Supplemental Materials and Methods from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplemental Materials and Methods from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplemental Materials and Methods
View article: Supplementary Figures from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplementary Figures from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplementary Figures
View article: Supplementary Figures from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplementary Figures from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplementary Figures
View article: Supplementary Tables from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplementary Tables from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplementary Tables
View article: Supplementary Tables from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib
Supplementary Tables from Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib Open
Supplementary Tables
View article: Parkin deficiency exacerbates particulate matter-induced injury by enhancing airway epithelial necroptosis
Parkin deficiency exacerbates particulate matter-induced injury by enhancing airway epithelial necroptosis Open
Exposure to fine particulate matter (PM) disrupts the function of airway epithelial barriers causing cellular stress and damage. However, the precise mechanisms underlying PM-induced cellular injury and the associated molecular pathways re…