Zhenli Liu
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View article: Vinegar-processed frankincense extracts alleviate colorectal cancer by butyric acid mediating M1 tumor-associated macrophage pyroptosis
Vinegar-processed frankincense extracts alleviate colorectal cancer by butyric acid mediating M1 tumor-associated macrophage pyroptosis Open
Background Olibanum (RF), a traditional Chinese medicinal resin, shows efficacy in colorectal cancer (CRC) treatment. Its vinegar-processed form (PF) is clinically recognized for enhanced therapeutic effects, with prior mechanistic studies…
View article: The protective effect of <i>Limosilactobacillus reuteri</i> against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice
The protective effect of <i>Limosilactobacillus reuteri</i> against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice Open
Limosilactobacillus reuteri QS01 is potential probiotic isolated from the intestinal microbiota of healthy women in early pregnancy. In the current study, we examined whether QS01 can prevent gestational diabetes mellitus (GDM) in an enhan…
View article: Chemical characteristics and anti-Escherichia coli mechanism of water-soluble extracts from yeast cell walls
Chemical characteristics and anti-Escherichia coli mechanism of water-soluble extracts from yeast cell walls Open
Background Antimicrobial resistance is a threat to global public health and requires the development of new antibiotic alternatives to treat bacterial infection. Infection with Escherichia coli ( E. coli ) is the most common cause of diarr…
View article: CEACAM1 as a molecular target in oral cancer
CEACAM1 as a molecular target in oral cancer Open
CEACAM1 is lowly expressed in oral cancer, the lower CEACAM1, the worse prognosis.
View article: A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs
A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs Open
Cefquinome is widely used to treat respiratory tract diseases of swine. While extra-label dosages of cefquinome could improve clinical efficacy, they might lead to excessively high residues in animal-derived food. In this study, a physiolo…
View article: Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or not?
Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or not? Open
Conjugated linoleic acid (CLA) has attracted great attention in recent years as a popular class of functional food that is broadly used. It refers to a group of geometric and positional isomers of linoleic acid (LA) with a conjugated doubl…
View article: Antimicrobial resistance and molecular typing of Salmonella in the chicken production chain in Hubei Province, China
Antimicrobial resistance and molecular typing of Salmonella in the chicken production chain in Hubei Province, China Open
Salmonella is a significant foodborne zoonotic pathogen that endangers both human and animal health. The goal of this research is to gain a preliminary understanding of Salmonella contamination and antimicrobial resistance in the chicken p…
View article: The Application of Hollow Fiber Cartridge in Biomedicine
The Application of Hollow Fiber Cartridge in Biomedicine Open
The hollow fiber cartridge has the advantages of good semi-permeability, high surface area to volume ratio, convenient operation, and so on. Its application in chemical analysis, drug in vitro experiment, hemodialysis, and other fields has…
View article: Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model
Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model Open
Model informed drug development is a valuable tool for drug development and clinical application due to its ability to integrate variability and uncertainty of data. This study aimed to determine an optimal dosage of ceftiofur against P. m…
View article: Rational Use of Danofloxacin for Treatment of Mycoplasma gallisepticum in Chickens Based on the Clinical Breakpoint and Lung Microbiota Shift
Rational Use of Danofloxacin for Treatment of Mycoplasma gallisepticum in Chickens Based on the Clinical Breakpoint and Lung Microbiota Shift Open
The study was to explore the rational use of danofloxacin against Mycoplasma gallisepticum (MG) based on its clinical breakpoint (CBP) and the effect on lung microbiota. The CBP was established according to epidemiological cutoff value (EC…
View article: Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study
Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study Open
Clostridium perfringens causes significant morbidity and mortality in swine worldwide. Avilamycin showed no cross resistance and good activity for treatment of C. perfringens . The aim of this study was to formulate optimal regimens of avi…
View article: PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets
PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets Open
Streptococcus suis (S. suis) causes severe respiratory diseases in pigs and is also an important pathogen causing hidden dangers to public health and safety. Acetylkitasamycin is a new macrolide agent that has shown good activity to Gram-p…
View article: Application of Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Model in Antimicrobial Resistance
Application of Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Model in Antimicrobial Resistance Open
Antimicrobial resistance is a major public health issue. The pharmacokinetic/pharmacodynamic (PK/PD) model is an essential tool to optimize dosage regimens and alleviate the emergence of resistance. The semi-mechanistic PK/PD model is a ma…
View article: Metabolite Identification and Pharmacokinetic Behavior of Diaveridine in the Plasma of Pigs and Chickens Based on Radioactive Tracing Coupled With LC/MS-IT-TOF Assay
Metabolite Identification and Pharmacokinetic Behavior of Diaveridine in the Plasma of Pigs and Chickens Based on Radioactive Tracing Coupled With LC/MS-IT-TOF Assay Open
Diaveridine (DVD) is widely used for the prevention and treatment of coccidiosis and leucocytozoonosis infections in food-producing animals. To gain a better understanding of DVD metabolism and pharmacokinetics in healthy Landrace/Doric Cr…
View article: Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats Open
Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations betwe…
View article: Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift
Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift Open
The aim of this study was to explore the prudent use of tylosin for the treatment of chronic respiratory infectious diseases in chickens caused by Mycoplasma gallisepticum (MG) based on its clinical breakpoint (CBP) and its effect on lung …
View article: How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?
How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension? Open
The presence of hypertension (HTN) in type 2 diabetes mellitus (DM) is a common phenomenon in more than half of the diabetic patients. Since HTN constitutes a predictor of vascular complications and cardiovascular disease in type 2 DM pati…
View article: Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs
Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs Open
Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative and gram-positive bacteria. The aim of this study was to…
View article: The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils
The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils Open
Cephalosporins are one of the most widely used antibiotics. When cephalosporins are discharged into the environment, they not only induce the production of antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARBs) but also…
View article: Correction to: Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling
Correction to: Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling Open
An amendment to this paper has been published and can be accessed via the original article.
View article: Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs and Broilers: Identification of a Suitable Marker Residue
Tissue Depletion of Olaquindox and Its Six Metabolites in Pigs and Broilers: Identification of a Suitable Marker Residue Open
The depletion profiles of olaquindox and its six major metabolites, including O1 ( N 1 -deoxyolaquindox), O2 (deoxyolaquindox), O3 (2-carboxamide-3-methylquinoxaline- N 4 -oxide), O4 (2-carboxymethylaminocarbonyl-3-methylquinoxaline- N 4 -…
View article: The Spectrum of Antimicrobial Activity of Cyadox against Pathogens Collected from Pigs, Chicken, and Fish in China
The Spectrum of Antimicrobial Activity of Cyadox against Pathogens Collected from Pigs, Chicken, and Fish in China Open
Cyadox has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of cyadox were assayed, and the antibacte…
View article: Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway
Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway Open
Nar could increase the ROS elimination and decrease eNOS uncoupling, subsequently upregulate the NO bioavailability and endothelial function by activating AMPKα/Sirt1 signaling pathway.
View article: Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China
Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China Open
Haemophilus parasuis can cause high morbidity and mortality in swine. Cefquinome possesses excellent antibacterial activity against pathogens causing diseases of the respiratory tract. This study aimed to establish the clinical breakpoint …