Zhenlong Chen
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View article: Lycobetaine Has Therapeutic Efficacy in Lung Squamous Cell Carcinoma by Targeting USP32 to Trigger Ferroptosis
Lycobetaine Has Therapeutic Efficacy in Lung Squamous Cell Carcinoma by Targeting USP32 to Trigger Ferroptosis Open
Ubiquitin-specific protease 32 (USP32), a deubiquitylating enzyme that controls the ubiquitin process, is overexpressed in multiple cancers and serves as a promising therapeutic target for cancer therapy. Drugs targeting ferroptosis have e…
View article: Lifestyle factors modified the mediation role of liver fibrosis in the association between occupational physical activity and blood pressure
Lifestyle factors modified the mediation role of liver fibrosis in the association between occupational physical activity and blood pressure Open
Objectives The study aimed to estimate the role of liver fibrosis in the association between occupational physical activity (OPA) and blood pressure (BP), which is modified by lifestyle factors. Methods The questionnaire survey and physica…
View article: Precise large deviations for a multidimensional risk model with regression dependence structure
Precise large deviations for a multidimensional risk model with regression dependence structure Open
In this paper, we consider a nonstandard multidimensional risk model, in which the claim sizes $\{\vec{X}_k, k\ge 1\}$ form an independent and identically distributed random vector sequence with dependent components. By assuming that there…
View article: The effects of construction vibration on stone cultural relics: a case study from the Qingdao Museum
The effects of construction vibration on stone cultural relics: a case study from the Qingdao Museum Open
The potential impact of vibration from nearby construction on four ancient stone statues in the Qingdao Museum was studied. Simulated but full-scale drilling, excavation and impact breaking were conducted to gather ground motion data which…
View article: Dynamic factor copula-based modeling for market risk optimization with an application to the real industry in China
Dynamic factor copula-based modeling for market risk optimization with an application to the real industry in China Open
As finance returns to its fundamental purpose of serving the real economy, its connections with various industries are strengthening. Accurately depicting the interdependence among these industries and mitigating financial risks has become…
View article: Editorial: Chemokine receptors and signaling in wound healing
Editorial: Chemokine receptors and signaling in wound healing Open
EDITORIAL article Front. Pharmacol., 07 September 2023Sec. Inflammation Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1282233
View article: Neutralization of excessive CCL28 improves wound healing in diabetic mice
Neutralization of excessive CCL28 improves wound healing in diabetic mice Open
Introduction: Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes mellitus (T2DM) and often result in limb amputation and even death. However, mechanisms by which T2DM and inflam…
View article: Quantitative Identification of Water Sources of Coalbed Methane Wells, Based on the Hydrogen and Oxygen Isotopes of Produced Water—A Case of the Zhijin Block, South China
Quantitative Identification of Water Sources of Coalbed Methane Wells, Based on the Hydrogen and Oxygen Isotopes of Produced Water—A Case of the Zhijin Block, South China Open
The quantitative identification of water sources is an important prerequisite for objectively evaluating the degree of aquifer interference and predicting the production potential of coalbed methane (CBM) wells. However, this issue has not…
View article: Modelling returns volatility: mixed-frequency model based on momentum of predictability
Modelling returns volatility: mixed-frequency model based on momentum of predictability Open
The estimation and prediction of financial asset volatility are important in terms of theoretical and practical applications. Considering that low-frequency and high-frequency information plays an important role in volatility prediction, t…
View article: Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes
Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes Open
Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes. Here, we investigated the role of chemokine CCL28 and its receptor CCR10 in downregulation of endothelial nitric oxide syntha…
View article: Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes
Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes Open
Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes. Here, we investigated the role of chemokine CCL28 and its receptor CCR10 in downregulation of endothelial nitric oxide syntha…
View article: Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes
Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes Open
Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes. Here, we investigated the role of chemokine CCL28 and its receptor CCR10 in downregulation of endothelial nitric oxide syntha…
View article: Stem cells from a malignant rat prostate cell line generate prostate cancers <i>in vivo</i>: a model for prostate cancer stem cell propagated tumor growth.
Stem cells from a malignant rat prostate cell line generate prostate cancers <i>in vivo</i>: a model for prostate cancer stem cell propagated tumor growth. Open
Cancer stem cells (CSCs) are resistant to conventional cancer therapies, permitting the repopulation of new tumor growth and driving disease progression. Models for testing prostate CSC-propagated tumor growth are presently limited yet nec…
View article: Experimental study on the evolution of rock strength and sealing properties under multi-cycles alternating loading
Experimental study on the evolution of rock strength and sealing properties under multi-cycles alternating loading Open
Different from the long-term and low-speed depletion of conventional gas fields or monotonous gas injection in carbon dioxide geological sequestration, the engineering background of multi-cycle intensive injection and production of undergr…
View article: Systemic risk in Chinese financial industries: a vine copula grouped CoVaR approach
Systemic risk in Chinese financial industries: a vine copula grouped CoVaR approach Open
This paper investigates systemic risk in Chinese financial industries by constructing a vine copula grouped CoVaR model, which accounts for the fact that various sub-industries are comprised of multiple financial institutions. The backtest…
View article: Dermal fibroblast phagocytosis of apoptotic cells: A novel pathway for wound resolution
Dermal fibroblast phagocytosis of apoptotic cells: A novel pathway for wound resolution Open
The effective clearance of apoptotic cells is an essential step in the resolution of healing wounds. In particular, blood vessel regression during wound resolution produces a significant number of apoptotic endothelial cells (ApoEC) that m…
View article: Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies Open
Our study suggests that job strain is an important risk factor for T2DM, especially among women. Appropriate preventive interventions in populations with high job strain would contribute to a reduction in T2DM risk.
View article: Asymmetric Multifractal Analysis of Rebar Futures and Spot Market in China
Asymmetric Multifractal Analysis of Rebar Futures and Spot Market in China Open
In this study, a wavelet denoising method is first used to eliminate the influence of noise. Then, an overlapping smooth window technique is introduced into the asymmetric multifractal detrended cross-correlation analysis method, which was…
View article: CCL28‐induced CCR10/eNOS interaction in angiogenesis and skin wound healing
CCL28‐induced CCR10/eNOS interaction in angiogenesis and skin wound healing Open
Chemokines and their receptors play important roles in vascular homeostasis, development, and angiogenesis. Little is known regarding the molecular signaling mechanisms activated by CCL28 chemokine via its primary receptor CCR10 in endothe…