Zuyun Liu
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View article: Dose–Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health
Dose–Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health Open
Objectives We aimed to examine the dose–response associations of grip strength and gait speed with multidimensional mental health among Chinese adults. Methods Cross‐sectional data on 661 adults from the ZheJiang longitudinal Study of Heal…
View article: Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex
Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex Open
The epigenetic mechanisms that connect aging to neurodegeneration remain incompletely understood, particularly in non-European populations. To address this gap, we constructed a comprehensive DNA methylation atlas of the human prefrontal c…
View article: Accelerated biological aging among chemical plant workers
Accelerated biological aging among chemical plant workers Open
Exposure to COEs, benzene, and coal dust may accelerate biological aging in occupational workers, primarily affecting cardiovascular and metabolic systems. These findings underscore the need for stricter occupational safety and regular hea…
View article: Child maltreatment and mental health in later life: The moderating role of longitudinal lifestyle patterns in a UK cohort
Child maltreatment and mental health in later life: The moderating role of longitudinal lifestyle patterns in a UK cohort Open
The study underscores the value of life course frameworks in addressing the long-term psychological impacts of CM. By linking early developmental risk with modifiable health behaviors across the lifespan, our findings inform strategies aim…
View article: Sex-specific associations of social isolation and loneliness with residual life expectancy at age 45 years among middle-aged and older adults in China
Sex-specific associations of social isolation and loneliness with residual life expectancy at age 45 years among middle-aged and older adults in China Open
Significant sex-specific differences were identified in the impact of social isolation and loneliness on residual life expectancy. Thus, implementing sex-specific public health strategies that focus on dual psychosocial intervention for me…
View article: Temporal trends in dementias in older adults attributable to high fasting plasma glucose from 1990 to 2021 and forecasted disease burden in 2040 in China and globally
Temporal trends in dementias in older adults attributable to high fasting plasma glucose from 1990 to 2021 and forecasted disease burden in 2040 in China and globally Open
Introduction The Global Burden of Diseases Study systematically updates the dementia burden attributable to high fasting plasma glucose (HFPG) to investigate the temporal trends of dementia burden and promote comparisons between countries,…
View article: Plasma Proteomic Signature of Frailty in 50,506 Adults
Plasma Proteomic Signature of Frailty in 50,506 Adults Open
Proteomics enables systematic elucidation of the biological mechanisms underlying health states including frailty. Here, through a large-scale proteome-wide association study (PWAS) encompassing 2,911 plasma proteins in 50,506 UK Biobank p…
View article: Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China Open
Background Ageing is a complex and multi‐dimensional process that manifests heterogeneities across different organs/systems, individuals and countries. We aimed to delineate the life‐course percentile curves and establish the normative val…
View article: Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis
Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis Open
This study presents compelling genetic evidence supporting a causal relationship between periodontitis and accelerated aging. Further research is required to validate these findings and investigate the underlying mechanisms.
View article: Associations of arthritis with functional disability and depressive symptoms in general <scp>US</scp> adults: <scp>NHANES</scp> 1988–1994 and 1999–2018
Associations of arthritis with functional disability and depressive symptoms in general <span>US</span> adults: <span>NHANES</span> 1988–1994 and 1999–2018 Open
Objectives This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed …
View article: Distinctive pattern mapping between cardiometabolic multimorbidity and neuropsychiatric disturbance in multi‐regional‐ethnical older adults
Distinctive pattern mapping between cardiometabolic multimorbidity and neuropsychiatric disturbance in multi‐regional‐ethnical older adults Open
Background Presence of cardiometabolic multimorbidity (CMM) has been linked to depressive symptoms in adults. The present study aimed to investigate the distinctive mapping between CMM and differential neuropsychiatric subsyndromes among m…
View article: DNA METHYLATION AGE ACCELERATION MEDIATES THE ASSOCIATIONS BETWEEN EARLY-LIFE CIRCUMSTANCES AND DEMENTIA RISK
DNA METHYLATION AGE ACCELERATION MEDIATES THE ASSOCIATIONS BETWEEN EARLY-LIFE CIRCUMSTANCES AND DEMENTIA RISK Open
Dementia represents critical public health challenges and exerts an immense economic burden. While mounting evidence has linked early-life circumstances to dementia risk, prior research mainly focused on single factors, failing to capture …
View article: HETEROGENEOUS METABOLOMIC AGING ACROSS THE SAME AGE AND PEDICTION OF HEALTH OUTCOME
HETEROGENEOUS METABOLOMIC AGING ACROSS THE SAME AGE AND PEDICTION OF HEALTH OUTCOME Open
Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been systematically…
View article: Cardiometabolic multimorbidity and neuropsychiatric disturbances in multiregional older adults
Cardiometabolic multimorbidity and neuropsychiatric disturbances in multiregional older adults Open
Introduction To investigate the association between cardiometabolic multimorbidity (CMM) patterns and dementia‐related neuropsychiatric symptoms (NPSs) among multiregional and ethnic seniors. Methods Four Asian studies (discovery) and UK B…
View article: A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors
A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors Open
Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non‐modifiable factors in metabolomic aging have not been systematically…
View article: Association between factors in life course and physiological dysregulation among the middle-aged and older population in Zhoushan city of Zhejiang province
Association between factors in life course and physiological dysregulation among the middle-aged and older population in Zhoushan city of Zhejiang province Open
Multiple life course factors contribute about 6.63% of the variance in physiological dysregulation in the middle aged and elderly population of the study area; subgroups with adverse life course experiences have higher levels of aging; and…
View article: Moderate BMI accumulation modified associations between blood benzene, toluene, ethylbenzene and xylene (BTEX) and phenotypic aging: mediating roles of inflammation and oxidative stress
Moderate BMI accumulation modified associations between blood benzene, toluene, ethylbenzene and xylene (BTEX) and phenotypic aging: mediating roles of inflammation and oxidative stress Open
The associations between blood benzene, toluene, ethylbenzene, and xylenes (BTEX) and biological aging among general adults remain elusive. The present study comprised 5780 participants from the National Health and Nutrition Examination Su…
View article: Proteome-wide association study identifies novel Alzheimer's disease- associated proteins
Proteome-wide association study identifies novel Alzheimer's disease- associated proteins Open
Background Alzheimer's disease (AD) is a progressive neurodegenerative disease, with a critical shortage of effective prevention and treatment options. Here, we aimed to identify proteins whose genetically regulated plasma levels were asso…
View article: Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort
Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort Open
Dynapenic obesity is associated with increased risks of dementia, especially in participants under 65 years and non-ε4-carrier, suggesting the importance of managing dynapenic obesity in the prevention of cognition-related disorders.
View article: Functional disability and receipt of informal care among Chinese adults living alone with cognitive impairment
Functional disability and receipt of informal care among Chinese adults living alone with cognitive impairment Open
This study highlights the high burden of functional disability but low coverage of informal care among Chinese adults living alone with cognitive impairment and calls for more resources to be allocated to this vulnerable subpopulation to i…
View article: Sex‐Specific Association Between Childhood Adversity and Accelerated Biological Aging
Sex‐Specific Association Between Childhood Adversity and Accelerated Biological Aging Open
Is childhood adversity associated with biological aging, and if so, does sex modify the association, and do lifestyle and mental health mediate the association? A lifespan analysis is conducted using data on 142 872 participants from the U…
View article: Heterogeneous metabolomic aging across the same age and prediction of health outcome
Heterogeneous metabolomic aging across the same age and prediction of health outcome Open
Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been systematically…