Zhenwei Han
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View article: ALG3 as a prognostic biomarker and mediator of PD-1 blockade resistance in hepatocellular carcinoma
ALG3 as a prognostic biomarker and mediator of PD-1 blockade resistance in hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, characterized by high heterogeneity and drug resistance, which significantly impacts clinical outcomes. The tumor microenvironment (TME) plays a…
View article: Polymorphisms in the <scp>FTO</scp> Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta‐Analysis
Polymorphisms in the <span>FTO</span> Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta‐Analysis Open
Background This meta‐analysis aimed to clarify the connection between six polymorphisms in the FTO gene and susceptibility to cancer. Methods The relevant literature on the relationship between FTO variants and cancer susceptibility was co…
View article: Single-cell transcriptomic data reveal the cellular heterogeneity of glutamine metabolism in gastric premalignant lesions and early gastric cancer
Single-cell transcriptomic data reveal the cellular heterogeneity of glutamine metabolism in gastric premalignant lesions and early gastric cancer Open
Glutamine metabolism is a hallmark of cancer metabolism. This study aims to perform a comprehensive and systematic single-cell profile of glutamine metabolism in premalignant and malignant gastric lesions. We use single-cell transcriptomic…
View article: ERβ-regulated circATP2B1/miR-204–3p/TWIST1 positive feedback loop facilitates epithelial to mesenchymal transition in clear cell renal cell carcinoma
ERβ-regulated circATP2B1/miR-204–3p/TWIST1 positive feedback loop facilitates epithelial to mesenchymal transition in clear cell renal cell carcinoma Open
Together, our results suggest that ERβ/circATP2B1/miR-204-3p/TWIST1 can promote EMT by forming a positive feedback loop, thus promoting the progression of ccRCC. Targeting this newly identified signaling pathway may more effectively contro…
View article: Predicting surgical efficacy and diagnosing histological inflammation: the clinical significance of prostate exosome proteins in benign prostatic hyperplasia
Predicting surgical efficacy and diagnosing histological inflammation: the clinical significance of prostate exosome proteins in benign prostatic hyperplasia Open
The study indicated that IPSS and PSEP (when t-PSA >4 ng/mL) were correlated with the severity of HI in patients with BPH. PSEP was linearly correlated with IPSS and the degree of reduction in IPSS after surgery. Consequently, PSEP may ser…
View article: Genetically predicted asthma and the risk of abnormal spermatozoa
Genetically predicted asthma and the risk of abnormal spermatozoa Open
Background Several previous animal and human studies have found a strong association between asthma and spermatozoa quality, but whether these associations are causal or due to bias remains to be elucidated. Methods We performed a two-samp…
View article: <i>MMP-9</i> gene polymorphisms on cancer risk: an updated systematic review and meta-analysis
<i>MMP-9</i> gene polymorphisms on cancer risk: an updated systematic review and meta-analysis Open
To provide a comprehensive account of the association of MMP-9 gene polymorphisms (rs3918242) with susceptibility to cancer. A literature search for eligible candidate gene studies published before May 27, 2022 was conducted in PubMed, Med…
View article: Downregulated RBM5 Enhances CARM1 Expression and Activates the PRKACA/GSK3β Signaling Pathway through Alternative Splicing-Coupled Nonsense-Mediated Decay
Downregulated RBM5 Enhances CARM1 Expression and Activates the PRKACA/GSK3β Signaling Pathway through Alternative Splicing-Coupled Nonsense-Mediated Decay Open
Downregulated RNA-binding motif protein 5 (RBM5) promotes the development and progression of various tumors, including bladder cancer (BC). Alternative splicing (AS) plays a crucial role in the progression of cancer by producing protein is…
View article: Cuproptosis related gene PDHB is identified as a biomarker inversely associated with the progression of clear cell renal cell carcinoma
Cuproptosis related gene PDHB is identified as a biomarker inversely associated with the progression of clear cell renal cell carcinoma Open
Background Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. Pyruvate dehydrogenase E1 subunit beta (PDHB) is one of the cuproptosis genesand is a nuclear-en…
View article: MNS16A polymorphism of the <i>TERT</i> gene on cancer risk: a systematic review and meta-analysis
MNS16A polymorphism of the <i>TERT</i> gene on cancer risk: a systematic review and meta-analysis Open
Some studies have suggested that MNS16A polymorphism in telomerase reverse transcriptase (TERT) gene is associated with cancer risk in various populations and types of cancer. However, the results of previous studies exploring this link ha…
View article: eNOS polymorphisms on male infertility: An updated systematic review and meta-analysis
eNOS polymorphisms on male infertility: An updated systematic review and meta-analysis Open
Background: This meta-analysis was performed to examine the association of 3 endothelial nitric oxide synthase (eNOS) gene polymorphisms with male infertility. Methods: The literature on the relation between the mutant of eNOS and male inf…
View article: ESR2 polymorphisms on prostate cancer risk: A systematic review and meta-analysis
ESR2 polymorphisms on prostate cancer risk: A systematic review and meta-analysis Open
Background: This meta-analysis was performed to address the association of 2 ESR2 gene polymorphisms (rs1256049 and rs4986938) with susceptibility to cancer. Methods: An extensive literature search for eligible candidate gene studies publi…
View article: DDX58 expression promotes inflammation and growth arrest in Sertoli cells by stabilizing p65 mRNA in patients with Sertoli cell-only syndrome
DDX58 expression promotes inflammation and growth arrest in Sertoli cells by stabilizing p65 mRNA in patients with Sertoli cell-only syndrome Open
Sertoli cell -only syndrome (SCOS) is a type of testicular pathological failure that causes male infertility and no effective treatment strategy, is available for this condition. Moreover, the molecular mechanism underlying its development…
View article: Cuproptosis related gene PDHB was identified as a biomarker and its up-regulation inhibited the invasion of renal clear cell carcinoma
Cuproptosis related gene PDHB was identified as a biomarker and its up-regulation inhibited the invasion of renal clear cell carcinoma Open
Background Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. PDHB is one of the genes responsible for cuproptosis and is a nuclear encoded pyruvate dehydroge…
View article: SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm
SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm Open
Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA splicing, but also in the regulation of transcription, translation, and cell signaling, and its dysregulation contributes to various diseases includ…
View article: Neutrophil extracellular traps-associated modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of clear cell renal cell carcinoma
Neutrophil extracellular traps-associated modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of clear cell renal cell carcinoma Open
Background Neutrophil extracellular traps (NETs) are web-like structures formed by neutrophils, and their main function is antimicrobial defense. Moreover, NETs have numerous roles in the pathogenesis and progression of cancers. However, t…
View article: Integrative Analysis Identifies TCIRG1 as a Potential Prognostic and Immunotherapy-Relevant Biomarker Associated with Malignant Cell Migration in Clear Cell Renal Cell Carcinoma
Integrative Analysis Identifies TCIRG1 as a Potential Prognostic and Immunotherapy-Relevant Biomarker Associated with Malignant Cell Migration in Clear Cell Renal Cell Carcinoma Open
Background: TCIRG1, also known as V-ATPase-a3, is critical for cellular life activities through its dependent acidification. Prior to the present research, its relationship with prognostic and tumor immunity in clear cell renal cell carcin…
View article: ESR2 polymorphisms on prostate cancer risk: A systematic review and meta-analysis
ESR2 polymorphisms on prostate cancer risk: A systematic review and meta-analysis Open
Purpose This meta-analysis was performed to address the association of two ESR2 gene polymorphisms (rs1256049 and rs4986938) with susceptibility to cancer. Methods Extensive literature retrieve for eligible candidate gene studies published…
View article: <i>ACPY2</i> gene polymorphisms on cancer risk: a systematic review and meta-analysis
<i>ACPY2</i> gene polymorphisms on cancer risk: a systematic review and meta-analysis Open
To provide a comprehensive account of the association of ACYP2 gene polymorphisms with susceptibility to cancer. A literature search for eligible candidate gene studies published before April 20, 2022 was conducted in the PubMed, Medline a…
View article: Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR‐34b‐5p/c‐Myc signaling
Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR‐34b‐5p/c‐Myc signaling Open
Early clinical studies indicated that estrogen receptor beta (ERβ) might play key roles to impact the progression of clear cell renal cell carcinoma (ccRCC). The detailed molecular mechanisms, however, remain unclear. Here, we found ERβ co…
View article: <i>ACPY2</i> gene polymorphisms on cancer risk: a systematic review and meta-analysis
<i>ACPY2</i> gene polymorphisms on cancer risk: a systematic review and meta-analysis Open
To provide a comprehensive account of the association of ACYP2 gene polymorphisms with susceptibility to cancer. A literature search for eligible candidate gene studies published before April 20, 2022 was conducted in the PubMed, Medline a…
View article: Efficacy and safety of laparoendoscopic single-site adrenalectomy versus conventional laparoscopic adrenalectomy: an updated systematic review and meta-analysis.
Efficacy and safety of laparoendoscopic single-site adrenalectomy versus conventional laparoscopic adrenalectomy: an updated systematic review and meta-analysis. Open
LESSA is significantly better in terms of postoperative pain, time to diet, length of hospital stay and wound size, but the operative time is significantly longer.
View article: Five <i>MDM4</i> gene polymorphisms on cancer risk: An updated systematic review and meta-analysis
Five <i>MDM4</i> gene polymorphisms on cancer risk: An updated systematic review and meta-analysis Open
Purpose The study aims to provide a comprehensive account of the association of five MDM4 gene polymorphisms (rs1380576, rs1563828, rs10900598, rs11801299, and rs4245739) with susceptibility to cancer. Methods A literature search for eligi…
View article: Right laparoscopic adrenalectomy vs. left laparoscopic adrenalectomy: a systematic review and meta-analysis.
Right laparoscopic adrenalectomy vs. left laparoscopic adrenalectomy: a systematic review and meta-analysis. Open
RLA is associated with a higher risk of bleeding and higher conversion rate.
View article: Prestenting Versus Nonprestenting on the Outcomes of Flexible Ureteroscopy for Large Upper Urinary Stones: A Systematic Review and Meta-Analysis
Prestenting Versus Nonprestenting on the Outcomes of Flexible Ureteroscopy for Large Upper Urinary Stones: A Systematic Review and Meta-Analysis Open
Introduction: The purpose of this article is to evaluate the efficacy and safety of prestenting (PS) versus non-PS (NPS) of flexible ureteroscopy (fURS) to treat large upper urinary stones. Methods: We conducted a systematic literature res…
View article: Intelligent Rehabilitation Assistance Tools for Distal Radius Fracture: A Systematic Review Based on Literatures and Mobile Application Stores
Intelligent Rehabilitation Assistance Tools for Distal Radius Fracture: A Systematic Review Based on Literatures and Mobile Application Stores Open
Objective. To systematically analyze the existing intelligent rehabilitation mobile applications (APPs) related to distal radius fracture (DRF) and evaluate their features and characteristics, so as to help doctors and patients to make evi…
View article: Efficacy and safety of various surgical treatments for proximal ureteral stone ≥10mm: A systematic review and network meta-analysis
Efficacy and safety of various surgical treatments for proximal ureteral stone ≥10mm: A systematic review and network meta-analysis Open
LU have the potential to be considered as the first treatment choice of proximal ureteral stone ≥10mm.
View article: Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer
Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer Open
The dysregulation of RNA binding proteins (RBPs) play critical roles in the progression of several cancers. However, the overall functions of RBPs in prostate cancer (PCa) remain poorly understood. Therefore, we first identified 144 differ…