Zihang Lu
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View article: Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain
Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain Open
BACKGROUNDInter- and intraindividual fluctuations in pain intensity pose a major challenge to treatment efficacy, with a majority of people perceiving their pain relief as inadequate. Recent preclinical studies have identified circadian rh…
View article: Research on Viscous Dissipation Index Assessment of Polymer Materials Using High-Frequency Focused Ultrasound
Research on Viscous Dissipation Index Assessment of Polymer Materials Using High-Frequency Focused Ultrasound Open
Polymer viscoelasticity is crucial for mechanical performance, but conventional low-frequency methods struggle to isolate viscous loss—a key viscosity indicator. This study introduces a high-frequency ultrasonic method to differentiate the…
View article: Differential impact of the COVID-19 pandemic on chlamydia and gonorrhoea cases among youth and young adults in Canada: an interrupted time series analysis
Differential impact of the COVID-19 pandemic on chlamydia and gonorrhoea cases among youth and young adults in Canada: an interrupted time series analysis Open
Introduction Globally, access to sexual health services declined during the COVID-19 pandemic. In Canada, pre-existing provincial differences in the organisation and delivery of sexual health services may have influenced how the pandemic a…
View article: Genetic overlap of severe psychiatric disorders with lung function and asthma suggests shared biological mechanisms
Genetic overlap of severe psychiatric disorders with lung function and asthma suggests shared biological mechanisms Open
Introduction Severe psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BIP) and anorexia nervosa (AN), are frequently comorbid with lung function decline and asthma. Despite considerable heritability, the genetic relat…
View article: Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials
Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials Open
Dr Sabri Soussi was awarded the Canadian Institutes of Health Research (CIHR) Doctoral Foreign Study Award (DFSA) and the Merit Awards Program (Department of Anesthesiology and Pain Medicine, University of Toronto, Canada) for the current …
View article: Bayesian additive regression trees for predicting childhood asthma in the CHILD cohort study
Bayesian additive regression trees for predicting childhood asthma in the CHILD cohort study Open
BART demonstrated promising prediction performance when compared to other machine learning algorithms. Future research could validate the BART in an external cohort to evaluate its reliability and generalizability.
View article: Clustering Longitudinal Data: A Review of Methods and Software Packages
Clustering Longitudinal Data: A Review of Methods and Software Packages Open
Summary Clustering of longitudinal data is becoming increasingly popular in many fields such as social sciences, business, environmental science, medicine and healthcare. However, it is often challenging due to the complex nature of the da…
View article: iClusterVB: Fast Integrative Clustering and Feature Selection for High Dimensional Data
iClusterVB: Fast Integrative Clustering and Feature Selection for High Dimensional Data Open
A variational Bayesian approach for fast integrative clustering and feature selection, facilitating the analysis of multi-view, mixed type, high-dimensional datasets with applications in fields like cancer research, genomics, and more.
View article: Quantifying sustained health system benefits of primary care-based integrated disease management for COPD: a 6-year interrupted time series study
Quantifying sustained health system benefits of primary care-based integrated disease management for COPD: a 6-year interrupted time series study Open
Background Severe exacerbation of chronic obstructive pulmonary disease (COPD) is a trajectory-changing life event for patients and a major contributor to health system costs. This study evaluates the real-world impact of a primary care, i…
View article: A sparse factor model for clustering high‐dimensional longitudinal data
A sparse factor model for clustering high‐dimensional longitudinal data Open
Recent advances in engineering technologies have enabled the collection of a large number of longitudinal features. This wealth of information presents unique opportunities for researchers to investigate the complex nature of diseases and …
View article: Longitudinal multisite study of the chronobiological control of chronic pain: the CircaHealth CircaPain study protocol
Longitudinal multisite study of the chronobiological control of chronic pain: the CircaHealth CircaPain study protocol Open
Introduction One in five Canadians lives with chronic pain. Evidence shows that some individuals experience pain that fluctuates in intensity following a circadian (24-hour) rhythm. Endogenous molecular rhythms regulate the function of phy…
View article: The CircaHealth CircaPain study protocol: A longitudinal multi-site study of the chronobiological control of chronic pain
The CircaHealth CircaPain study protocol: A longitudinal multi-site study of the chronobiological control of chronic pain Open
Introduction One in five Canadians lives with chronic pain. Evidence shows that some individuals experience pain that fluctuates in intensity following a circadian (24-hour) rhythm. Endogenous molecular rhythms regulate the function of mos…
View article: Non-collapsibility and Built-in Selection Bias of Hazard Ratio in Randomized Controlled Trials
Non-collapsibility and Built-in Selection Bias of Hazard Ratio in Randomized Controlled Trials Open
Background: The hazard ratio of the Cox proportional hazards model is widely used in randomized controlled trials to assess treatment effects. However, two properties of the hazard ratio including the non-collapsibility and built-in select…
View article: Clinical phenotypes of cardiogenic shock survivors: insights into late host responses and long‐term outcomes
Clinical phenotypes of cardiogenic shock survivors: insights into late host responses and long‐term outcomes Open
Aims An elevated risk of adverse events persists for years in cardiogenic shock (CS) survivors with high mortality rate and physical/mental disability. This study aims to link clinical CS‐survivor phenotypes with distinct late host‐respons…
View article: A Sparse Factor Model for Clustering High-Dimensional Longitudinal Data
A Sparse Factor Model for Clustering High-Dimensional Longitudinal Data Open
Recent advances in engineering technologies have enabled the collection of a large number of longitudinal features. This wealth of information presents unique opportunities for researchers to investigate the complex nature of diseases and …
View article: A Bayesian latent class model for integrating multi-source longitudinal data: application to the CHILD cohort study
A Bayesian latent class model for integrating multi-source longitudinal data: application to the CHILD cohort study Open
Multi-source longitudinal data have become increasingly common. This type of data refers to longitudinal datasets collected from multiple sources describing the same set of individuals. Representing distinct features of the individuals, ea…
View article: Identification of obstructive sleep apnea in children with obesity: A cluster analysis approach
Identification of obstructive sleep apnea in children with obesity: A cluster analysis approach Open
Background Obstructive sleep apnea (OSA) is a heterogeneous disorder with a prevalence of 25%–60% in children with obesity. There is a lack of diagnostic tools to identify those at high risk for OSA. Method Children with obesity, aged 8–19…
View article: Joint clustering multiple longitudinal features: A comparison of methods and software packages with practical guidance
Joint clustering multiple longitudinal features: A comparison of methods and software packages with practical guidance Open
Clustering longitudinal features is a common goal in medical studies to identify distinct disease developmental trajectories. Compared to clustering a single longitudinal feature, integrating multiple longitudinal features allows additiona…
View article: Mindfulness on Rumination in Patients with Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mindfulness on Rumination in Patients with Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Objective: To systematically evaluate the effectiveness of mindfulness-based interventions (MBIs) on rumination among patients with depression and their efficacy across countries and year of publication and control conditions. Methods: Web…
View article: A Joint Modeling Approach for Clustering Mixed-Type Multivariate Longitudinal Data: Application to the CHILD Cohort Study
A Joint Modeling Approach for Clustering Mixed-Type Multivariate Longitudinal Data: Application to the CHILD Cohort Study Open
In epidemiological and clinical studies, identifying patients' phenotypes based on longitudinal profiles is critical to understanding the disease's developmental patterns. The current study was motivated by data from a Canadian birth cohor…
View article: Effects of childhood trauma on nonsuicidal self‐injury in adolescent patients with bipolar II depression
Effects of childhood trauma on nonsuicidal self‐injury in adolescent patients with bipolar II depression Open
Objective This study was performed to explore the effect of childhood trauma on nonsuicidal self‐injury (NSSI) in adolescents with bipolar II (BD II) depression. Methods Based on the diagnostic criteria of the DSM‐5 and structured intervie…
View article: The effectiveness of exposure and response prevention combined with pharmacotherapy for obsessive-compulsive disorder: A systematic review and meta-analysis
The effectiveness of exposure and response prevention combined with pharmacotherapy for obsessive-compulsive disorder: A systematic review and meta-analysis Open
Objective To systematically evaluate the effectiveness of exposure and response prevention (ERP) combined with medication on obsessive-compulsive disorder (OCD). Methods PubMed, Web of Science, EBSCO, Cochrane, Embase, and Science Direct d…