Zhenyi Ma
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View article: A Macro–micro–macro Radiogenomic Framework Identifies FIBCD1 as a Key Immune-modulating Biomarker in Breast Cancer
A Macro–micro–macro Radiogenomic Framework Identifies FIBCD1 as a Key Immune-modulating Biomarker in Breast Cancer Open
Background Breast cancer prognosis remains challenging due to tumor heterogeneity and the limited predictive power of conventional clinical models. Integrating imaging features with molecular data may improve individualized risk stratifica…
View article: Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC
Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC Open
Introduction Small cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance. Autophagy, a conserved cellular process, is implicated in many canc…
View article: Rare manifestation of familial vitreous amyloidosis caused by Gly103Arg transthyretin
Rare manifestation of familial vitreous amyloidosis caused by Gly103Arg transthyretin Open
AIM: To identify and analyze the genotype of the patients with special ocular manifestations of familial vitreous amyloidosis (FVA) in a Chinese Han family. METHODS: Pars plana vitrectomy (PPV) surgery was performed on a 52-year-old Chines…
View article: Table S2 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S2 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S2, related to Figure 4: Genes downregulated/upregulated >2-fold by Spi-B transient expression in A549 cells
View article: Supplemental figures from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Supplemental figures from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Figure S1, related to Figure 3. Effect of Spi-B on EMT. (A) Phase-contrast micrographs of HBECs expressing vector or Spi-B. Scale bars are 100μm; (B) western blot showed expression of Spi-B, E-cadherin, Vimentin and Actin; (C) Quantitative…
View article: Supplemental figures from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Supplemental figures from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Figure S1, related to Figure 3. Effect of Spi-B on EMT. (A) Phase-contrast micrographs of HBECs expressing vector or Spi-B. Scale bars are 100μm; (B) western blot showed expression of Spi-B, E-cadherin, Vimentin and Actin; (C) Quantitative…
View article: Table S1 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S1 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S1. Oligonucleotide sequences used for RT-PCR, ChIP, 3C assays and luciferase reporters
View article: Table S2 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S2 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S2, related to Figure 4: Genes downregulated/upregulated >2-fold by Spi-B transient expression in A549 cells
View article: Table S3 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S3 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S3, related to Figure 4: List of Spi-B-dependent genes categorized by biological function.
View article: Data from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Data from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Dissociation from epithelial sheets and invasion through the surrounding stroma are critical early events during epithelial cancer metastasis. Here we find that a lymphocyte lineage–restricted transcription factor, Spi-B, is frequently exp…
View article: Table S3 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S3 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S3, related to Figure 4: List of Spi-B-dependent genes categorized by biological function.
View article: Data from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Data from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Dissociation from epithelial sheets and invasion through the surrounding stroma are critical early events during epithelial cancer metastasis. Here we find that a lymphocyte lineage–restricted transcription factor, Spi-B, is frequently exp…
View article: Table S1 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
Table S1 from Spi-B–Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors Open
Table S1. Oligonucleotide sequences used for RT-PCR, ChIP, 3C assays and luciferase reporters
View article: Yeast-based evolutionary modeling of androgen receptor mutations and natural selection
Yeast-based evolutionary modeling of androgen receptor mutations and natural selection Open
Cancer progression is associated with the evolutionary accumulation of genetic mutations that are biologically significant. Mutations of the androgen receptor (AR) are associated with the development of prostate cancer (PCa) by responding …
View article: Simulating androgen receptor selection in designer yeast
Simulating androgen receptor selection in designer yeast Open
Androgen receptor (AR) mutation is closely associated with prostate cancer (PCa) and is one of the mechanisms of resistance to PCa therapies such as AR antagonists. Although sequencing technologies like next-generation sequencing (NGS) con…
View article: Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells
Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells Open
The switch from anchorage-dependent to anchorage-independent growth is essential for epithelial metastasis. The underlying mechanism, however, is not fully understood. In this study, we identified growth factor independent-1 (GFI1), a tran…
View article: Simulating androgen receptor selection in designer yeast
Simulating androgen receptor selection in designer yeast Open
We established a designer yeast assay to simulate natural androgen receptor (AR) selection using AR antagonists. Yeast HIS3 gene transactivation was associated with the ligand-induced recruitment of steroid receptor coactivator-1 (SRC-1) b…
View article: Enhancing the Effectiveness of Trimethylchlorosilane Purification Process Monitoring with Variational Autoencoder
Enhancing the Effectiveness of Trimethylchlorosilane Purification Process Monitoring with Variational Autoencoder Open
In modern industry, process monitoring plays a significant role in improving the quality of process conduct. With the higher dimensional of the industrial data, the monitoring methods based on the latent variables have been widely applied …
View article: Single-domain antibody screening by <i>is</i>PLA-seq
Single-domain antibody screening by <i>is</i>PLA-seq Open
Single-domain antibody (sdAb) holds the promising strategies for diverse research and translational applications. Here, we describe a method for the adaptation of the in situ proximity ligation assay ( is PLA) followed by sequencing ( is P…
View article: Autophagic flux in cancer cells at the invasive front in the tumor-stroma border
Autophagic flux in cancer cells at the invasive front in the tumor-stroma border Open
Cancer cells at the invasive front directly interact with stromal tissue that provides a microenvironment with mechanical, nutrient, and oxygen supply characteristics distinct from those of intratumoral tissues. It has long been known that…
View article: An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli Open
Host cells use several anti-bacterial pathways to defend against pathogens. Here, using a uropathogenic Escherichia coli (UPEC) infection model, we demonstrate that bacterial infection upregulates RhoB, which subsequently promotes intracel…
View article: SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells
SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells Open
Anoikis (detachment‐induced cell death) is a specific type of programmed cell death which occurs in response to the loss of the correct extracellular matrix connections. Anoikis resistance is an important mechanism in cancer invasiveness a…
View article: Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549�cells in nude mice
Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549�cells in nude mice Open
Nuclear protein 1 (NUPR1)/p8, a transcriptional regulator, has the ability to facilitate lung cancer cell survival. Adeno‑associated virus (AAV)‑based vectors are efficient vehicles for gene transfer and expression. In this study, an AAV‑m…
View article: Spleen tyrosine kinase <scp>SYK</scp>(L) interacts with <scp>YY</scp>1 and coordinately suppresses <i><scp>SNAI</scp>2</i> transcription in lung cancer cells
Spleen tyrosine kinase <span>SYK</span>(L) interacts with <span>YY</span>1 and coordinately suppresses <i><span>SNAI</span>2</i> transcription in lung cancer cells Open
Spleen tyrosine kinase ( SYK ) is a nonreceptor tyrosine kinase with dual properties of an oncoprotein and an oncosuppressor in distinctive cell types. In solid cancers, two isoforms SYK (L) and SYK (S) of SYK were recently identified due …