Explanipedia

Effects of maternal edible THC consumption on offspring lung growth and function in a rhesus macaque model Open

Lyndsey E. Shorey‐Kendrick, Adam Crosland, Matthias C. Schabel, Ilhem Messaoudi, Minzhe Guo , et al. · 2025

In a translational rhesus macaque model, chronic prenatal delta-9-tetrahydrocannabinol exposure resulted in decreased lung volumes in offspring measured at 6 mo of age. These decreases correlated with altered DNA methylation in the lung, i…

Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness Open

Kayla R. Williams, Hoyt A.T.K. Bright, A.D. Fryer, David B. Jacoby, Zhenying Nie · 2025

The impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or regular diet 8 weeks before br…

Location, Location, Location: Unpacking Eosinophils’ Roles in Obesity-related Asthma Open

Zhenying Nie · 2024

Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet Open

Becky J. Proskocil, Gina N Bash, David B. Jacoby, A.D. Fryer, Zhenying Nie · 2024

This study investigates how eosinophils influence systemic metabolism and airway function in obesity. Known for their immune functions, eosinophils also mitigate obesity-related hyperinsulinemia, reducing airway hyperresponsiveness in obes…

Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma Open

Nana-Fatima Haruna, Sergejs Berdnikovs, Zhenying Nie · 2024

Eosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinoph…

Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring Open

Gina N. Calco, Yem J. Alharithi, Kayla R. Williams, David B. Jacoby, A.D. Fryer , et al. · 2023

Our study reveals a novel potential mechanism, by which maternal high-fat diet increases the risk and severity of asthma in offspring. We found that exposure to maternal high-fat diet in mice leads to hyperinnervation of airway sensory ner…

Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice Open

Gina N. Calco, Jessica N. Maung, David B. Jacoby, A.D. Fryer, Zhenying Nie · 2022

Obesity-induced asthma responds poorly to all current pharmacological interventions, including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism. Since insulin resistance and hyperinsulinemia are common in obe…

Mechanisms of Obesity-related Asthma: Is Insulin Getting on Your Nerves? Open

Zhenying Nie, A.D. Fryer, David B. Jacoby, Matthew G. Drake · 2022

Metformin prevents airway hyperreactivity in rats with dietary obesity Open

Gina N. Calco, Becky J. Proskocil, David B. Jacoby, A.D. Fryer, Zhenying Nie · 2021

Increased insulin is associated with obesity-related airway hyperreactivity and asthma. We tested whether the use of metformin, an antidiabetic drug used to reduce insulin resistance, can reduce circulating insulin, thereby preventing airw…

Pioglitazone prevents obesity-related airway hyperreactivity and neuronal M<sub>2</sub> receptor dysfunction Open

Becky J. Proskocil, A.D. Fryer, David B. Jacoby, Zhenying Nie · 2021

Obesity-related asthma often presents with more severe symptoms than non-obesity-related asthma and responds poorly to current treatments. Both insulin resistance and hyperinsulinemia are common in obesity. We have shown that increased ins…

Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats Open

Becky J. Proskocil, Gina N. Calco, Zhenying Nie · 2021

Obesity increases incidence and severity of asthma but the molecular mechanisms are not completely understood. Hyperinsulinemia potentiates vagally induced bronchoconstriction in obese rats. Since bronchoconstriction results from airway sm…

Unraveling the connection between eosinophils and obesity Open

Gina N. Calco, A.D. Fryer, Zhenying Nie · 2020

Obesity affects more than 650 million adults worldwide and is a major risk factor for a variety of serious comorbidities. The prevalence of obesity has tripled in the past forty years and continues to rise. Eosinophils have recently been i…

Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice Open

Zhenying Nie, Jessica N. Maung, David B. Jacoby, A.D. Fryer · 2019

Eosinophils mediate airway hyperresponsiveness by increasing vagally mediated reflex bronchoconstriction. Here, we tested whether circulating or airway eosinophils change nerve function. Airway resistance in response to aerosolized 5-hydro…

Eosinophils increase airway sensory nerve density in mice and in human asthma Open

Matthew G. Drake, Gregory D. Scott, Emily Blum, Katie M. Lebold, Zhenying Nie , et al. · 2018

Eosinophils increase airway sensory nerve density in humans with asthma and in mice, which promotes airway hyperresponsiveness.

Eosinophil and airway nerve interactions in asthma Open

Matthew G. Drake, Katie M. Lebold, Quinn R. Roth‐Carter, Alexandra Pincus, Emily Blum , et al. · 2018

Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosi…

Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus Open

Matthew G. Drake, Elizabeth R. Bivins-Smith, Becky J. Proskocil, Zhenying Nie, Gregory D. Scott , et al. · 2016

Respiratory viruses cause asthma exacerbations. Because eosinophils are the prominent leukocytes in the airways of 60-70% of patients with asthma, we evaluated the effects of eosinophils on a common respiratory virus, parainfluenza 1, in t…

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