Zhenzhen Deng
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View article: WITHDRAWN: Association Between Bone Mineral Density, Sleep Disturbance and Sleep Duration: Results from Observational and Mendelian randomization study
WITHDRAWN: Association Between Bone Mineral Density, Sleep Disturbance and Sleep Duration: Results from Observational and Mendelian randomization study Open
The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to …
View article: A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine
A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine Open
One of the biggest obstacles to treating pancreatic ductal adenocarcinoma (PDAC) is chemotherapy resistance. Macrophages are an essential element of the innate immune system and are distributed in almost every tissue in the body. Among the…
View article: Metabolomic profiling of plasma reveals differential disease severity markers in avian influenza A(H7N9) infection patients
Metabolomic profiling of plasma reveals differential disease severity markers in avian influenza A(H7N9) infection patients Open
We first revealed the plasma metabolomic characteristics of H7N9 patients and found that a machine-learning model based on plasma metabolites could predict the risk of death for H7N9 in the early stage of admission.
View article: Potential role of CFLAR in enhancing 5-FU sensitivity and modulating immune cell infiltration in breast cancer
Potential role of CFLAR in enhancing 5-FU sensitivity and modulating immune cell infiltration in breast cancer Open
In conclusion, this study reveals the novel roles of CFLAR in enhancing chemotherapy sensitivity and patient outcome in BRCA and underscores its potential as a therapeutic target. These results supported CFLAR as a therapeutic target and p…
View article: WITHDRAWN: Association Between Bone Mineral Density, Sleep Disturbance and Sleep Duration: Results from Observational and Mendelian randomization study
WITHDRAWN: Association Between Bone Mineral Density, Sleep Disturbance and Sleep Duration: Results from Observational and Mendelian randomization study Open
Purpose The relationship between bone health and sleep problems still remains controversial across different study conditions. This study aims to investigate the association between sleep disturbance, sleep duration and bone mineral densit…
View article: Distinct roles of CD244 expression in cancer diagnosis and prognosis: A pan-cancer analysis
Distinct roles of CD244 expression in cancer diagnosis and prognosis: A pan-cancer analysis Open
The abnormal expression of tumor associated genes in pan-cancer is closely related to the clinicopathological features of distinct cancer types. Thus, identifying the role of specific genes in pan-cancer is needed for developing effective …
View article: Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin
Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin Open
Chemotherapy remains the cornerstone of pancreatic cancer treatment. However, the dense interstitial and immunosuppressive microenvironment frequently render the ineffective anti-tumor activity of chemotherapeutic agents. Macrophages play …
View article: Rhabdomyolysis associated with newer-generation anti-seizure medications (ASMs): a real-world retrospective and pharmacovigilance study
Rhabdomyolysis associated with newer-generation anti-seizure medications (ASMs): a real-world retrospective and pharmacovigilance study Open
Objective: Rhabdomyolysis is a potentially fatal adverse reaction mostly triggered by certain medications. Few real-world studies have shown a clear association between newer-generation anti-seizure medications (ASMs) and rhabdomyolysis. W…
View article: IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis
IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis Open
Objective: Few real-world studies have shown clear association between interleukin (IL)-17 inhibitors and inflammatory bowel disease (IBD) onset. This study investigated the reporting prevalence and evaluated the clinical features and mana…
View article: Valproic-induced Fanconi syndrome: Clinical features, risk factors, diagnosis and management
Valproic-induced Fanconi syndrome: Clinical features, risk factors, diagnosis and management Open
Objective Although Fanconi syndrome (FS) induced by valproate (VPA) has occasionally been reported, the detailed clinical features of the disease remain unclear. The aim of this study was to elucidate the clinical features of patients with…
View article: Diagnosis and Management of Fingolimod-Associated Macular Edema
Diagnosis and Management of Fingolimod-Associated Macular Edema Open
Objective To investigate the clinical features, treatment, and prognosis of fingolimod-associated macular edema (FAME) and to provide a reference for its rational management. Methods FAME-related case reports were included in a pooled anal…
View article: Analysis of Clinical Features of Non-steroidal Anti-inflammatory Drugs Induced Kounis Syndrome
Analysis of Clinical Features of Non-steroidal Anti-inflammatory Drugs Induced Kounis Syndrome Open
Background Current knowledge of Kounis syndrome induced by non-steroidal anti-inflammatory drugs (NSAIDs) is based on case reports. This study aimed to investigate the clinical features of Kounis syndrome. Methods Case reports of the NSAID…
View article: Analysis of Clinical Features of Kounis Syndrome Induced by Cephalosporin
Analysis of Clinical Features of Kounis Syndrome Induced by Cephalosporin Open
Background Cephalosporins are an increasingly encountered cause of Kounis syndrome. The present study examined the clinical features of cephalosporin-induced Kounis syndrome and provided references for diagnosis, prevention, treatment, and…
View article: Analysis of clinical characteristics of Kounis syndrome induced by contrast media
Analysis of clinical characteristics of Kounis syndrome induced by contrast media Open
KS is a rare adverse reaction of contrast media. Radiologists should recognize this rare but serious disease to ensure rapid diagnosis and proper management.
View article: Correlation of Initial Dose Option With Plasma Vancomycin Exposure and Safety in Older Chinese Patients: a Cohort Retrospective Study
Correlation of Initial Dose Option With Plasma Vancomycin Exposure and Safety in Older Chinese Patients: a Cohort Retrospective Study Open
Background: The option of initial vancomycin dose for older patients is still controversy.Methods: Vancomycin trough concentrations in older patients who received vancomycin initial dose of ≥1.5g/day or dosing recommended by package insert…
View article: Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet
Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet Open
Metabolic syndrome (MetS) is a pathological state of multiple metabolic abnormalities. Dietary fibers (DFs) has been widely concerned about its positive role in MetS. Different from the DFs of terrestrial plants, the DFs of seaweeds has un…
View article: Glucuronomannan GM2 from Saccharina japonica Enhanced Mitochondrial Function and Autophagy in a Parkinson’s Model
Glucuronomannan GM2 from Saccharina japonica Enhanced Mitochondrial Function and Autophagy in a Parkinson’s Model Open
Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is caused by dopamine depletion in the striatum and dopaminergic neuron degeneration in the substantia nigra. In our previous study, we hydrolyzed the fucoidan f…
View article: Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model Open
Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found that a het…
View article: DNA adsorption on nanoscale zeolitic imidazolate framework-8 enabling rational design of a DNA-based nanoprobe for gene detection and regulation in living cells
DNA adsorption on nanoscale zeolitic imidazolate framework-8 enabling rational design of a DNA-based nanoprobe for gene detection and regulation in living cells Open
Boosting DNA-based nanotheranostics for gene detection and regulation by ZIF-8.
View article: Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs)
Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs) Open
A variety of biologically active products have been isolated from Gracilariopsis lemaneiformis. In the present study, two novel angiotensin-converting enzyme (ACE) inhibitory peptides, FQIN [M(O)] CILR, and TGAPCR, were screened and identi…
View article: Mass spectrometry based methods for the enzyme substrate screening and kinetics analysis
Mass spectrometry based methods for the enzyme substrate screening and kinetics analysis Open
Revealing the relationship between the enzyme and substrate could provide insights into signaling networks. Mass spectrometry has been widely applied for the large scale interrogation of biological systems in proteomics, and also has taken…
View article: Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus
Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus Open
These finding suggest that basophil activation-dependent autoantibody and IL-17 production may constitute a critical pathogenic mechanism in SLE.
View article: Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2
Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2 Open
Background/Aims: Basophils have been reported to infiltrate skin lesions in various skin diseases, but not in systemic lupus erythematosus (SLE). This study investigated basophil infiltration in SLE and its mechanism. Methods: Twenty newly…