Zhiyi Lan
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View article: Global, regional, and national burdens of lower extremity peripheral arterial disease from 1990 to 2021 and projections to 2050: global burden of disease study 2021
Global, regional, and national burdens of lower extremity peripheral arterial disease from 1990 to 2021 and projections to 2050: global burden of disease study 2021 Open
Background The global and regional burden of lower extremity peripheral artery disease (LEPAD) and its trends have not been systematically studied. Utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2…
View article: Epigenetic control of tissue resident memory T cells
Epigenetic control of tissue resident memory T cells Open
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thu…
View article: Effects of music therapy on intravitreal injections: a randomised clinical trial
Effects of music therapy on intravitreal injections: a randomised clinical trial Open
Introduction: Procedures are frequently performed under regional or local anaesthesia, where patients maintain a level of consciousness. This has been associated with heightened pre- and intraprocedural anxiety levels, which may increase t…
View article: Matching-Adjusted Indirect Comparison of Sotorasib Versus Adagrasib in Previously Treated Advanced/Metastatic Non-Small Cell Lung Cancer Harboring KRAS G12C Mutation
Matching-Adjusted Indirect Comparison of Sotorasib Versus Adagrasib in Previously Treated Advanced/Metastatic Non-Small Cell Lung Cancer Harboring KRAS G12C Mutation Open
In this MAIC, sotorasib and adagrasib showed comparable efficacy in previously treated advanced KRAS G12C-mutated NSCLC. Among patients with baseline brain metastases, PFS point estimates favored sotorasib. Sotorasib also demonstrated a fa…
View article: Health State Utility Values in Fabry Disease: Insights from the Pegunigalsidase Alfa Clinical Trials
Health State Utility Values in Fabry Disease: Insights from the Pegunigalsidase Alfa Clinical Trials Open
NCT03018730, NCT02795676, NCT03180840.
View article: <i>N</i> <sup>6</sup> -methyladenosine modification–tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis
<i>N</i> <sup>6</sup> -methyladenosine modification–tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis Open
Disrupted N 6 -methyladenosine (m 6 A) modification modulates various inflammatory disorders. However, the role of m 6 A in regulating cutaneous inflammation remains elusive. Here, we reveal that the m 6 A and its methyltransferase METTL3 …
View article: Impact of patient support programmes among patients with severe asthma treated with biological therapies: a systematic literature review and indirect treatment comparison
Impact of patient support programmes among patients with severe asthma treated with biological therapies: a systematic literature review and indirect treatment comparison Open
Introduction Effective treatment of severe asthma requires patient adherence to inhaled and biological medications. Previous work has shown that patient support programmes (PSP) can improve adherence in patients with chronic diseases, but …
View article: Adjudicated thrombotic events in a cotemporary multicenter cohort of patients with COVID-19: findings from the CORONA-VTE Registry
Adjudicated thrombotic events in a cotemporary multicenter cohort of patients with COVID-19: findings from the CORONA-VTE Registry Open
Background Venous thromboembolism (VTE) and arterial thrombosis emerged among the main serious complications of coronavirus disease 2019 (COVID-19) in the early post-infection period and during convalescence. Data are less consistent about…
View article: Adjudicated cardiovascular events in a cotemporary multicenter cohort of patients with COVID-19: findings from the CORONA-VTE Registry
Adjudicated cardiovascular events in a cotemporary multicenter cohort of patients with COVID-19: findings from the CORONA-VTE Registry Open
Background Coronavirus disease 2019 (COVID-19) is associated with excess risk of cardiovascular events in the early post-infection period and during convalescence. Despite the progress in our understanding of cardiovascular complications, …
View article: Assessing the Diagnostic Performance of New Commercial Interferon-γ Release Assays for<i>Mycobacterium tuberculosis</i>Infection: A Systematic Review and Meta-Analysis
Assessing the Diagnostic Performance of New Commercial Interferon-γ Release Assays for<i>Mycobacterium tuberculosis</i>Infection: A Systematic Review and Meta-Analysis Open
Background We compared 6 new interferon-γ release assays (IGRAs; hereafter index tests: QFT-Plus, QFT-Plus CLIA, QIAreach, Wantai TB-IGRA, Standard E TB-Feron, and T-SPOT.TB/T-Cell Select) with World Health Organization (WHO)–endorsed test…
View article: Real‐world persistence of erenumab for preventive treatment of chronic and episodic migraine: Retrospective real‐world study
Real‐world persistence of erenumab for preventive treatment of chronic and episodic migraine: Retrospective real‐world study Open
Objective To describe the real‐world treatment persistence (defined as the continuation of medication for the prescribed treatment duration), demographics and clinical characteristics, and treatment patterns for patients prescribed erenuma…
View article: Active testing of groups at increased risk of acquiring SARS-CoV-2 in Canada: costs and human resource needs
Active testing of groups at increased risk of acquiring SARS-CoV-2 in Canada: costs and human resource needs Open
BACKGROUND: Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely passive, which impedes epidemic control. We defined active testing strategies for SARS-CoV-2 using reverse transcription polymerase chain react…
View article: An Interactive Excel File to Estimate Costs of Expanded Testing for COVID-19 by RT-PCR and/or Serologic Tests
An Interactive Excel File to Estimate Costs of Expanded Testing for COVID-19 by RT-PCR and/or Serologic Tests Open
This is an interactive excel file that can be used to estimate the costs of various scenarios of expanded testing for COVID-19. Several sensitivity analyses are possible. Testing is enabled for populations of various size and COVID-19 prev…
View article: Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis
Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis Open
Objective To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19). Design Systematic review and meta-analysis. Data sources Medline, bioRxiv, and medRxiv from 1 January to 30 April 2020, using subj…
View article: Aminoglycosides and Capreomycin in the Treatment of Multidrug-resistant Tuberculosis: Individual Patient Data Meta-analysis of 12 030 Patients From 25 Countries, 2009–2016
Aminoglycosides and Capreomycin in the Treatment of Multidrug-resistant Tuberculosis: Individual Patient Data Meta-analysis of 12 030 Patients From 25 Countries, 2009–2016 Open
Background As new drugs are developed for multidrug-resistant tuberculosis (MDR-TB), the role of currently used drugs must be reevaluated. Methods We combined individual-level data on patients with pulmonary MDR-TB published during 2009–20…
View article: Standardised shorter regimens <i>versus</i> individualised longer regimens for rifampin- or multidrug-resistant tuberculosis
Standardised shorter regimens <i>versus</i> individualised longer regimens for rifampin- or multidrug-resistant tuberculosis Open
We sought to compare the effectiveness of two World Health Organization (WHO)-recommended regimens for the treatment of rifampin- or multidrug-resistant (RR/MDR) tuberculosis (TB): a standardised regimen of 9–12 months (the “shorter regime…
View article: Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline
Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline Open
Background: The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-res…
View article: Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children
Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children Open
Introduction Zika virus (ZIKV) infection during pregnancy is a known cause of microcephaly and other congenital and developmental anomalies. In the absence of a ZIKV vaccine or prophylactics, principal investigators (PIs) and international…
View article: Analysis of loss to follow-up in 4099 multidrug-resistant pulmonary tuberculosis patients
Analysis of loss to follow-up in 4099 multidrug-resistant pulmonary tuberculosis patients Open
Loss to follow-up (LFU) of ≥2 consecutive months contributes to the poor levels of treatment success in multidrug-resistant tuberculosis (MDR-TB) reported by TB programmes. We explored the timing of when LFU occurs by month of MDR-TB treat…
View article: The mTST – An mHealth approach for training and quality assurance of tuberculin skin test administration and reading
The mTST – An mHealth approach for training and quality assurance of tuberculin skin test administration and reading Open
The mTST approach appears to be a reliable tool to assess TST administration. The mTST approach was accurate to read indurations of 0-4mm or 15+mm, but less accurate for reactions of 5-14mm. We believe the mTST approach could be useful for…
View article: Determinants of tuberculosis trends in six Indigenous populations of the USA, Canada, and Greenland from 1960 to 2014: a population-based study
Determinants of tuberculosis trends in six Indigenous populations of the USA, Canada, and Greenland from 1960 to 2014: a population-based study Open
Public Health Department of the Cree Board of Health and Social Services of James Bay.
View article: Effectiveness and safety of standardised shorter regimens for multidrug-resistant tuberculosis: individual patient data and aggregate data meta-analyses
Effectiveness and safety of standardised shorter regimens for multidrug-resistant tuberculosis: individual patient data and aggregate data meta-analyses Open
We assessed the effectiveness and safety of standardised, shorter multidrug-resistant tuberculosis (MDR-TB) regimens by pooling data from observational studies. Published studies were identified from medical databases; unpublished studies …
View article: An updated systematic review and meta-analysis for treatment of multidrug-resistant tuberculosis
An updated systematic review and meta-analysis for treatment of multidrug-resistant tuberculosis Open
This systematic review aimed to update the current evidence for multidrug-resistant tuberculosis (MDR-TB) treatment. We searched for studies that reported treatment information and clinical characteristics for at least 25 patients with mic…
View article: Treatment of human disease due to<i>Mycobacterium bovis</i>: a systematic review
Treatment of human disease due to<i>Mycobacterium bovis</i>: a systematic review Open
Mycobacterium bovis , a member of the Mycobacterium tuberculosis complex, is an important cause of disease in cattle, but it can also cause disease in humans [1]. Transmission to humans generally occurs after close contact with infected an…