Han Yan
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View article: HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity
HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity Open
Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data from 5,339 cases from China, Europe, Korea, Japan…
View article: Effect of H2S on endothelial barrier function impairment in anorectal vascular plexus caused by deoxycholic acid
Effect of H2S on endothelial barrier function impairment in anorectal vascular plexus caused by deoxycholic acid Open
Introduction As a vascular-related disease, hemorrhoids cause pathological changes, such as abnormal dilation in the anorectal vascular plexus (AVP), which may be closely related to injury to vascular endothelial barrier function (VEBF). E…
View article: HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity
HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity Open
In this study, we investigated the effects of HLA-DQB1*03:01 on the onset age of type-1 narcolepsy. We pooled data from 5,339 cases from China, Europe, Korea, Japan, and the United States to conduct the first transethnic study on age of on…
View article: Population pharmacokinetics and dosing optimization of teicoplanin in renal transplant patients
Population pharmacokinetics and dosing optimization of teicoplanin in renal transplant patients Open
The objectives of this study were to investigate the population pharmacokinetic (PK) characteristics of teicoplanin in renal transplant patients and to provide recommendations for optimal teicoplanin dosing regimens. A total of 99 renal tr…
View article: HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease
HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease Open
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement and bulbar-associated dysfunction. The presence of IgLON5-antibodies i…
View article: Telomere-to-telomere and haplotype-resolved genome assembly of the Chinese cork oak (Quercus variabilis)
Telomere-to-telomere and haplotype-resolved genome assembly of the Chinese cork oak (Quercus variabilis) Open
The Quercus variabilis , a deciduous broadleaved tree species, holds significant ecological and economical value. While a chromosome-level genome for this species has been made available, it remains riddled with unanchored sequences and ga…
View article: Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy Open
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with enviro…
View article: ATP Secretion and Metabolism in Regulating Pancreatic Beta Cell Functions and Hepatic Glycolipid Metabolism
ATP Secretion and Metabolism in Regulating Pancreatic Beta Cell Functions and Hepatic Glycolipid Metabolism Open
Diabetes (DM), especially type 2 diabetes (T2DM) has become one of the major diseases severely threatening public health worldwide. Islet beta cell dysfunctions and peripheral insulin resistance including liver and muscle metabolic disorde…
View article: Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells
Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells Open
FAM3A is a recently identified mitochondrial protein that stimulates pancreatic-duodenal homeobox 1 (PDX1) and insulin expressions by promoting ATP release in islet β cells. In this study, the role of intracellular ATP in FAM3A-induced PDX…
View article: Population pharmacokinetics and exposure‐response analysis of tigecycline in patients with hospital‐acquired pneumonia
Population pharmacokinetics and exposure‐response analysis of tigecycline in patients with hospital‐acquired pneumonia Open
Background Tigecycline has been widely used to treat hospital‐acquired pneumonia (HAP) off‐label since it is effective against a wide range of multidrug‐resistant bacteria. However, no recommended dosage for this indication has been evalua…
View article: VSMC-Specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy
VSMC-Specific Deletion of FAM3A Attenuated Ang II-Promoted Hypertension and Cardiovascular Hypertrophy Open
Rationale: Dysregulated purinergic signaling transduction plays important roles in the pathogenesis of cardiovascular diseases. However, the role and mechanism of vascular smooth muscle cell (VSMC)-released ATP in the regulation of blood p…
View article: Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging
Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging Open
Our study revealed novel miRNA-mRNA interaction networks and signaling pathways for AA, providing novel insights into the development of human AA. Future studies are needed to investigate the potential significance of these miRNA-mRNA inte…
View article: Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire
Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire Open
Type 1 narcolepsy (T1N) is a neurological condition, in which the death of hypocretin-producing neurons in the lateral hypothalamus leads to excessive daytime sleepiness and symptoms of abnormal Rapid Eye Movement (REM) sleep. Known trigge…
View article: Genome-Wide Association and Functional Studies Identify <i>SCML4</i> and <i>THSD7A</i> as Novel Susceptibility Genes for Coronary Artery Disease
Genome-Wide Association and Functional Studies Identify <i>SCML4</i> and <i>THSD7A</i> as Novel Susceptibility Genes for Coronary Artery Disease Open
Objective— The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. Approach and Results— We perf…
View article: SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population
SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population Open
Considering the biological roles of WNT4 and WNT5A involved in adipogenesis, we aimed to investigate whether SNPs in WNT4 and WNT5A contribute to obesity related traits in Han Chinese population. Targeted genomic sequence for WNT4 and WNT5…
View article: Nocturnal Dynamics of Sleep–Wake Transitions in Patients With Narcolepsy
Nocturnal Dynamics of Sleep–Wake Transitions in Patients With Narcolepsy Open
We conclude that narcolepsy mainly alters the control of wake-episode durations but not sleep-episode durations, irrespective of cataplexy. Observed distributions of shortest wake and sleep durations suggest that differences in scoring hab…
View article: Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease
Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease Open
Mutations in the genes low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) and myocyte enhancer factor 2A (MEF2A) were reported in families with coronary artery disease (CAD). We intend to determine the mutational spectrum of t…
View article: Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome
Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome Open
There are lower orexin A levels in the symptomatic phase than in remission and a fall and rise in blood pressure and heart rate, suggesting a role for orexin dysregulation in KLS pathophysiology.