Zhetong Su
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View article: Efficacy of Pulsatilla saponin B4 for treatment dairy cows affected with clinical mastitis
Efficacy of Pulsatilla saponin B4 for treatment dairy cows affected with clinical mastitis Open
In order to explore the therapeutic effect of natural compound Pulsatilla saponin B4 (PSB4) on clinical mastitis (CM) in dairy cows, 40 dairy cows with CM and 20 healthy dairy cows were selected as experimental samples in a large dairy far…
View article: Pharmacokinetics and safety evaluation of anemoside B4 in healthy Beagle dogs
Pharmacokinetics and safety evaluation of anemoside B4 in healthy Beagle dogs Open
Background Anemoside B4 (AB4), a pentacyclic triterpenoid saponin extracted from the traditional Chinese medicinal herb Pulsatilla chinensis , has shown anti-inflammatory and immunomodulatory effects in both preclinical and clinical studie…
View article: Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial
Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial Open
Background Canine pneumonia is a serious respiratory disease often associated with Canine Infectious Respiratory Disease (CIRD). Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of anti…
View article: Proteomics analysis reveals the mechanism of anemoside B4 in treating clinical mastitis in dairy cows
Proteomics analysis reveals the mechanism of anemoside B4 in treating clinical mastitis in dairy cows Open
(1) Background: The therapeutic efficacy of AB4 in cows with CM is well-established, but the specific mechanism remains to be explored. This study was based on Label free relative quantitative proteomics technology to reveal the internal m…
View article: Potential Immunoregulatory Mechanism of Plant Saponins: A Review
Potential Immunoregulatory Mechanism of Plant Saponins: A Review Open
Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves and have a variety of biological activities including immunomodulatory, anti-inflammatory effects, and hypoglycemic properties. They demonstrate …
View article: Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification
Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification Open
The specific immunoadjuvant effects of AB4 have been demonstrated to modulate the growth and maturation of immune organs and enhance the secretion and cellular activity of pertinent immune molecules. The utilization of network pharmacology…
View article: Blood metabolomics reveals the therapeutic effect of Pueraria polysaccharide on calf diarrhea
Blood metabolomics reveals the therapeutic effect of Pueraria polysaccharide on calf diarrhea Open
View article: Effects of Anemoside B4 on Plasma Metabolites in Cows with Clinical Mastitis
Effects of Anemoside B4 on Plasma Metabolites in Cows with Clinical Mastitis Open
Anemoside B4 has a good curative effect on cows with CM; however, its impact on their metabolic profiles is unclear. Based on similar somatic cell counts and clinical symptoms, nine healthy dairy cows and nine cows with CM were selected, r…
View article: Pueraria lobata polysaccharides alleviate neonatal calf diarrhea by modulating gut microbiota and metabolites
Pueraria lobata polysaccharides alleviate neonatal calf diarrhea by modulating gut microbiota and metabolites Open
Introduction Neonatal calf diarrhea (NCD) is still one of the most critical diseases in calf rearing. Studies have shown that Pueraria lobata polysaccharides (PLP) have intense antioxidant and immunomodulatory activity and modulate gut mic…
View article: Pueraria lobate polysaccharides alleviate neonatal calf diarrhea by modulating gut microbiota and metabolites
Pueraria lobate polysaccharides alleviate neonatal calf diarrhea by modulating gut microbiota and metabolites Open
Background Neonatal calf diarrhea (NCD) is still one of the most critical diseases in calf rearing. Studies have shown that Pueraria lobata polysaccharides (PLP) have intense antioxidant and immunomodulatory activity and modulate gut micro…
View article: Effect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics
Effect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics Open
Objective Intramuscular injection of anemoside B4 (AB4) has a superior therapeutic effect on clinical mastitis in lactating cows. Here, we explored AB4’s effect on milk whey in clinical mastitis-affected cows using proteomics. Methods Amon…
View article: Effect of a natural plant ingredient — Pulsatilla saponin B4 on clinical mastitis and serum inflammatory indices in dairy cows
Effect of a natural plant ingredient — Pulsatilla saponin B4 on clinical mastitis and serum inflammatory indices in dairy cows Open
Background: Bovine mastitis is an inflammatory reaction of the breast caused by pathogenic bacteria infection or breast injury, which affect milk yield and quality and poses severe threat to the health of dairy cows. Pulsatilla chinensis h…
View article: Effect of a natural plant ingredient — Pulsatilla saponin B4 on clinical mastitis and serum inflammatory indices in dairy cows
Effect of a natural plant ingredient — Pulsatilla saponin B4 on clinical mastitis and serum inflammatory indices in dairy cows Open
Background To investigate the effect of Pulsatilla saponin B4, a purified extract form Pulsatilla Chinensis , on the treatment of clinical mastitis in dairy cows, 12 healthy cows were used as the control group (group A, no treatment), and …