Zhexin Wang
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View article: Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Open
Electron cryomicroscopy (cryo-EM) allows high-resolution spatial visualization of biological specimens, however, it is challenging to chemically identify densities observed in cryo-EM. To overcome this, we combined cryo-EM with chemical im…
View article: Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms
Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms Open
All bacterial biofilms contain an extracellular matrix rich in filamentous molecules 1 that self-associate 2–4 , conferring emergent properties to bacteria 5 , including antibiotic tolerance 6 . Pseudomonas aeruginosa is a human pathogen t…
View article: Structural biology inside multicellular specimens using electron cryotomography
Structural biology inside multicellular specimens using electron cryotomography Open
The electron cryomicroscopy (cryo-EM) resolution revolution has shifted structural biology into a new era, enabling the routine structure determination of macromolecular complexes at an unprecedented rate. Building on this, electron cryoto…
View article: Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus Open
Type IV pili (T4Ps) are abundant in many bacterial and archaeal species, where they play important roles in both surface sensing and twitching motility, with implications for adhesion, biofilm formation and pathogenicity. While Type IV pil…
View article: Predicting non-small cell lung cancer lymph node metastasis: integrating ctDNA mutation/methylation profiling with positron emission tomography-computed tomography (PET-CT) scan: protocol for a prospective clinical trial (LUNon-invasive Study)
Predicting non-small cell lung cancer lymph node metastasis: integrating ctDNA mutation/methylation profiling with positron emission tomography-computed tomography (PET-CT) scan: protocol for a prospective clinical trial (LUNon-invasive Study) Open
This study is registered on www.clinicaltrials.gov (NCT06358222).
View article: Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling Open
The alteration of metabolic processes has been found to have significant impacts on the development of hepatocellular carcinoma (HCC). Nevertheless, the effects of dysfunction of tyrosine metabolism on the development of HCC remains to be …
View article: Structure of the <i>Pseudomonas aeruginosa</i> PAO1 Type IV pilus
Structure of the <i>Pseudomonas aeruginosa</i> PAO1 Type IV pilus Open
Type IV pili (T4Ps), which are abundant in many bacterial and archaeal species, have been shown to play important roles in both surface sensing and twitching motility, with implications for adhesion, biofilm formation and pathogenicity. Wh…
View article: Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations
Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations Open
View article: Improvement of Whole-body Bone Planar Images on a Bone-dedicated Single-photon Emission Computed Tomography Scanner by Blind Deconvolution Algorithm
Improvement of Whole-body Bone Planar Images on a Bone-dedicated Single-photon Emission Computed Tomography Scanner by Blind Deconvolution Algorithm Open
Purpose: We have developed a bone-dedicated collimator with higher sensitivity but slightly degraded resolution on single-photon emission computed tomography (SPECT) for planar bone scintigraphy, compared with conventional low-energy high-…
View article: Structure of the native myosin filament in the relaxed cardiac sarcomere
Structure of the native myosin filament in the relaxed cardiac sarcomere Open
The thick filament is a key component of sarcomeres, the basic units of striated muscle 1 . Alterations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and muscle diseases 2 . Despite the…
View article: In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filament
In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filament Open
The thick filament is a key component of sarcomeres, the basic force-generating and load-bearing unit of striated muscle 1 . Mutations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and …
View article: Structural Biochemistry of Muscle Contraction
Structural Biochemistry of Muscle Contraction Open
Muscles are essential for movement and heart function. Contraction and relaxation of muscles rely on the sliding of two types of filaments—the thin filament and the thick myosin filament. The thin filament is composed mainly of filamentous…
View article: A cryogenic, coincident fluorescence, electron, and ion beam microscope
A cryogenic, coincident fluorescence, electron, and ion beam microscope Open
Cryogenic electron tomography (cryo-ET) combined with subtomogram averaging, allows in situ visualization and structure determination of macromolecular complexes at subnanometre resolution. Cryogenic focused ion beam (cryo-FIB) micromachin…
View article: Case report: Complete resection of invasive thymoma invading the superior vena cava and right atrium under cardiopulmonary bypass support
Case report: Complete resection of invasive thymoma invading the superior vena cava and right atrium under cardiopulmonary bypass support Open
Here we describe an uncommon case of a 48-year-old male patient with an invasive thymoma invading the superior vena cava, bilateral innominate veins, right internal jugular vein, right subclavian vein, right atrium, azygos vein, and part o…
View article: Author response: A cryogenic, coincident fluorescence, electron, and ion beam microscope
Author response: A cryogenic, coincident fluorescence, electron, and ion beam microscope Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Cryogenic electron tom…
View article: Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors
Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors Open
View article: A cryogenic, coincident fluorescence, electron and ion beam microscope
A cryogenic, coincident fluorescence, electron and ion beam microscope Open
Cryogenic electron tomography (cryo-ET) combined with sub-tomogram averaging, allows in-situ visualisation and structure determination of macromolecular complexes at sub-nanometre resolution. Cryogenic focused ion beam (cryo-FIB) micromach…
View article: The improved success rate and reduced complications of a novel localization device vs. hookwire for thoracoscopic resection of small pulmonary nodules: a single-center, open-label, randomized clinical trial
The improved success rate and reduced complications of a novel localization device vs. hookwire for thoracoscopic resection of small pulmonary nodules: a single-center, open-label, randomized clinical trial Open
Chinese Clinical Trial Registry ChiCTR1900027346.
View article: Re-thinking and Re-labeling LIDC-IDRI for Robust Pulmonary Cancer Prediction
Re-thinking and Re-labeling LIDC-IDRI for Robust Pulmonary Cancer Prediction Open
The LIDC-IDRI database is the most popular benchmark for lung cancer prediction. However, with subjective assessment from radiologists, nodules in LIDC may have entirely different malignancy annotations from the pathological ground truth, …
View article: Limited airway resection and reconstruction for paediatric tracheobronchial inflammatory myofibroblastic tumour
Limited airway resection and reconstruction for paediatric tracheobronchial inflammatory myofibroblastic tumour Open
OBJECTIVES The paediatric tracheobronchial inflammatory myofibroblastic tumour (IMT) is a rare disease. Whether limited surgical resection is a feasible surgical approach for these patients remains controversial. The objectives of this stu…
View article: Primary pulmonary choriocarcinoma in male: report a case with genetic testing and review of the literature
Primary pulmonary choriocarcinoma in male: report a case with genetic testing and review of the literature Open
Primary pulmonary choriocarcinoma is an extremely rare and highly malignant tumor difficult to detect in the early stage. By analyzing the previous literature, the patients with active treatment have more extended survival periods than the…
View article: Indocyanine green fluorescence-navigated thoracoscopy versus traditional inflation-deflation approach in precise uniportal segmentectomy: a short-term outcome comparative study
Indocyanine green fluorescence-navigated thoracoscopy versus traditional inflation-deflation approach in precise uniportal segmentectomy: a short-term outcome comparative study Open
Our study indicated that the ICGF-based navigation approach is a simple, effective, and reliable technique that can greatly facilitate the uniportal VATS segmentectomy.
View article: Faithful learning with sure data for lung nodule diagnosis
Faithful learning with sure data for lung nodule diagnosis Open
Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First, benign-mal…
View article: Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin Open
In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the underlying mechanism remains nebulous. In this work, we used cryo–electron tomography and subtomogram averaging to reveal structures of native nebul…
View article: Establishment and validation of a novel immune-related prognostic signature in malignant pleural mesothelioma
Establishment and validation of a novel immune-related prognostic signature in malignant pleural mesothelioma Open
This research developed and verified a new type of immune prognostic signature based on five IRGs, which can predict the prognosis of tumor patients and provide new ideas for individualized treatment.
View article: A Quantitative Study of Relationship between Pulmonary Nodule Malignancy and Surrounding Pleurae, Airways and Vessels
A Quantitative Study of Relationship between Pulmonary Nodule Malignancy and Surrounding Pleurae, Airways and Vessels Open
View article: Multi-scale integrative analyses identify THBS2<sup>+</sup> cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
Multi-scale integrative analyses identify THBS2<sup>+</sup> cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma Open
Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the agg…
View article: A Quantitative Study of Relationship between Pulmonary Nodule Malignancy and Surrounding Pleurae, Airways and Vessels
A Quantitative Study of Relationship between Pulmonary Nodule Malignancy and Surrounding Pleurae, Airways and Vessels Open
View article: Neoadjuvant immunotherapy facilitates resection of surgically-challenging lung squamous cell cancer
Neoadjuvant immunotherapy facilitates resection of surgically-challenging lung squamous cell cancer Open
Our findings showed the clinical promise of neoadjuvant immunotherapy plus surgery for locally-advanced lung squamous cell carcinoma. Computed tomography scan displays a poor role in assessing the resectability after neoadjuvant immunother…
View article: Venovenous extracorporeal membrane oxygenation-assisted tracheobronchial surgery: a retrospective analysis and literature review
Venovenous extracorporeal membrane oxygenation-assisted tracheobronchial surgery: a retrospective analysis and literature review Open
VV-ECMO is a safe and feasible ventilation mode when intraoperative oxygen saturation cannot be well maintained during tracheobronchial surgery.