Explanipedia

DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer Open

Yu Zhu, Zhi-Bi Zhang, Xueqin Dai, Wenjing Liu, Jian Sun , et al. · 2025

Dissecting the Binding Affinity of Anti-SARS-CoV-2 Compounds to Human Transmembrane Protease, Serine 2: A Computational Study Open

Yongwei Shi, Jianxin Shen, Tao Yan, Yuan-Ling Xia, Zhi-Bi Zhang , et al. · 2025

The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulation…

Computational Insights into SARS-CoV-2 Main Protease Mutations and Nirmatrelvir Efficacy: The Effects of P132H and P132H-A173V Open

Yuan-Ling Xia, Wen-Wen Du, Yongping Li, Tao Yan, Zhi-Bi Zhang , et al. · 2024

Nirmatrelvir, a pivotal component of the oral antiviral Paxlovid for COVID-19, targets the SARS-CoV-2 main protease (M^pro) as a covalent inhibitor. Here, we employed combined computational methods to explore how the prevalent Om…

Identification of and Mechanistic Insights into SARS-CoV-2 Main Protease Non-Covalent Inhibitors: An In-Silico Study Open

Jianxin Shen, Wen-Wen Du, Yuan-Ling Xia, Zhi-Bi Zhang, Zefen Yu , et al. · 2023

The indispensable role of the SARS-CoV-2 main protease (Mpro) in the viral replication cycle and its dissimilarity to human proteases make Mpro a promising drug target. In order to identify the non-covalent Mpro inhibitors, we performed a …

Mechanistic Origin of Different Binding Affinities of SARS-CoV and SARS-CoV-2 Spike RBDs to Human ACE2 Open

Zhi-Bi Zhang, Yuan-Ling Xia, Jianxin Shen, Wen-Wen Du, Yun‐Xin Fu , et al. · 2022

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (RBDCoV2) has a higher binding affinity to the human receptor angiotensin-converting enzyme 2 (ACE2) than the SARS-CoV RBD (RBDCoV). Here, we performed molecular dynamics (M…

Mechanistic origin of different binding affinities of SARS-CoV and SARS-CoV-2 spike RBDs to human ACE2 Open

Zhi-Bi Zhang, Yuan-Ling Xia, Jianxin Shen, Wen-Wen Du, Yun‐Xin Fu , et al. · 2022

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein mediates viral entry into host cells through binding to the cell-surface receptor angiotensin-converting enzyme 2 (ACE2). It has been shown that SARS-CoV-2 RBD (RBD CoV2 ) h…

Exploring the Cold-Adaptation Mechanism of Serine Hydroxymethyltransferase by Comparative Molecular Dynamics Simulations Open

Zhi-Bi Zhang, Yuan-Ling Xia, Guang-Heng Dong, Yun‐Xin Fu, Shu-Qun Liu · 2021

Cold-adapted enzymes feature a lower thermostability and higher catalytic activity compared to their warm-active homologues, which are considered as a consequence of increased flexibility of their molecular structures. The complexity of th…

CRISPR technology: The engine that drives cancer therapy Open

Mingtao Zhang, Emily Eshraghian, Omar Al Jammal, Zhi-Bi Zhang, Xiao Zhu · 2020

How to overcome the side effects of tumor immunotherapy Open

Li Shang, Zhi-Bi Zhang, Wing‐Fu Lai, Liao Cui, Xiao Zhu · 2020

The interactive effects of ketamine and ethanol on dopamine expression in the ventral tegmental area of rats Open

Zhi-Bi Zhang, Tianyong Xu, Dingyun You, Yi Shuai, Qing Liu , et al. · 2018

These results indicated the possibility that combined drug treatment might positively affect the mesencephalic DA reward system.

小鼠卵母细胞中母源基因 Ooep 可能参与同源重组介导的DNA双链损伤修复过程 Open

Dajian He, Lin Wang, Zhi-Bi Zhang, Kun Guo, Jingzheng Li , et al. · 2018

DNA damage in oocytes can cause infertility and birth defects. DNA double-strand breaks (DSBs) are highly deleterious and can substantially impair genome integrity. Homologous recombination (HR)-mediated DNA DSB repair plays dominant roles…

Zhi-Bi Zhang YOU? Author Swipe