Zhimin Huang
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View article: BCR-ABL tyrosine kinase inhibitors associated acute kidney injury: a pharmacovigilance study based on the FAERS database with a case report
BCR-ABL tyrosine kinase inhibitors associated acute kidney injury: a pharmacovigilance study based on the FAERS database with a case report Open
View article: Construction and Implications of Nomogram for Predicting Sustained Glycemic Remission After Short‐Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes
Construction and Implications of Nomogram for Predicting Sustained Glycemic Remission After Short‐Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Open
Background Early short‐term intensive insulin therapy may induce sustained glycemic remission in type 2 diabetes. However, patients' responses vary greatly. Exploring key factors to improve glycemic control and predict the probability of r…
View article: Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy—from a 10-year population-based cohort study
Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy—from a 10-year population-based cohort study Open
Background Vitamin D (VD) deficiency has been found to be common and associated with a higher risk of adverse outcomes in chronic kidney disease (CKD), according to certain studies. However, whether it is associated with the progression of…
View article: Low-intensity pulsed ultrasound stimulation to treat renal fibrosis through inhibiting tubular IL-1R
Low-intensity pulsed ultrasound stimulation to treat renal fibrosis through inhibiting tubular IL-1R Open
Low-intensity pulsed ultrasound stimulation (LIPUS) has become increasingly appreciated for its therapeutic effect on kidney diseases. However, its role and biological mechanism in treating chronic kidney disease remain poorly defined. Her…
View article: Microbially Induced Sand Cementation Using Lysinibacillus fusiformis NM01
Microbially Induced Sand Cementation Using Lysinibacillus fusiformis NM01 Open
Microbial-induced calcium carbonate precipitation (MICP) is a novel sand solidification technique that has garnered significant attention in recent years. A key challenge for the application of MICP technology is the environmental adaptabi…
View article: Virus Diseases of Peonies
Virus Diseases of Peonies Open
Peonies (Paeonia spp.) are renowned for their beautiful ornamental flowers and significant cultural, medicinal, and economic values. Based on growth habit, peonies are categorized into herbaceous and tree peonies. Viral infections in peoni…
View article: A single-center experience of central nervous system tumors in children under three years old
A single-center experience of central nervous system tumors in children under three years old Open
Purpose This study aims to summarize the characteristics of children under three years old (≤3 years) with central nervous system (CNS) tumors and to investigate the factors that influence their overall survival (OS) time. Methods We treat…
View article: Delta corticomedullary apparent diffusion coefficient on MRI as a biomarker for prognosis in IgA nephropathy
Delta corticomedullary apparent diffusion coefficient on MRI as a biomarker for prognosis in IgA nephropathy Open
ΔADC was significantly associated with kidney function and enabled a reliable evaluation of kidney IF severity in IgAN patients. Low ΔADC can predict a high 5-year kidney progression risk in IgAN, independent of important clinical factors.…
View article: Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial
Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial Open
Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long term glycaemic outcomes in patients with…
View article: Iron Accumulation in Ovarian Microenvironment Damages the Local Redox Balance and Oocyte Quality in Aging Mice
Iron Accumulation in Ovarian Microenvironment Damages the Local Redox Balance and Oocyte Quality in Aging Mice Open
View article: Nonlinear pulse compression technique based on in multi-pass plano-cancave cavity
Nonlinear pulse compression technique based on in multi-pass plano-cancave cavity Open
Ultrafast femtosecond laser system with hundreds of microjoules of energy, operating at a repetition frequency of several kilohertz, has very important applications in many fields such as medicine, mid-infrared laser generation, industrial…
View article: Early Oral Antihyperglycemic Regimens after Short-Term Intensive Insulin Therapy Significantly Improve Glycemic Control in Newly Diagnosed Type 2 Diabetes Patients with Severe Hyperglycemia - A Multi-Center, Open-Label, Randomized Trial
Early Oral Antihyperglycemic Regimens after Short-Term Intensive Insulin Therapy Significantly Improve Glycemic Control in Newly Diagnosed Type 2 Diabetes Patients with Severe Hyperglycemia - A Multi-Center, Open-Label, Randomized Trial Open
View article: Serum 25-hydroxyvitamin D as a predictive biomarker of clinical outcomes in patients with primary membranous nephropathy
Serum 25-hydroxyvitamin D as a predictive biomarker of clinical outcomes in patients with primary membranous nephropathy Open
Background Primary membranous nephropathy (PMN) is an immune-related disease with increased morbidity and the most common cause of adult nephrotic syndrome (NS). The serum 25-hydroxyvitamin D [25(OH)D)], a biomarker of vitamin D (VD) statu…
View article: Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in Type 2 Diabetes
Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in Type 2 Diabetes Open
Objectives Growing evidence demonstrated that vitamin D levels had been linked to type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in light of various extraskeletal effects. Therefore, the present study aimed to evaluate th…
View article: Validation of Controlled Attenuation Parameter Measured by FibroScan as a Novel Surrogate Marker for the Evaluation of Metabolic Derangement
Validation of Controlled Attenuation Parameter Measured by FibroScan as a Novel Surrogate Marker for the Evaluation of Metabolic Derangement Open
Background/Objectives Renaming non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated fatty liver disease (MAFLD) suggests a shift of emphasis to the accompanying metabolic disturbance. Controlled attenuation paramet…
View article: Association of Glomerular Complement C4c Deposition With the Progression of Diabetic Kidney Disease in Patients With Type 2 Diabetes
Association of Glomerular Complement C4c Deposition With the Progression of Diabetic Kidney Disease in Patients With Type 2 Diabetes Open
Objectives: As accumulating data supporting the potential role of the complement system in the pathogenesis of diabetic kidney disease (DKD), the present study aimed to explore the association of glomerular complement C4c deposition…
View article: Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy
Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy Open
Background Mitochondrial dysfunction contributes to the pathogenesis of diabetic nephropathy (DN). Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role in the transport of pyruvate into…
View article: Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database
Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database Open
View article: Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis Open
Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied kidney diseases …
View article: MON-901 Primary Amenorrhea, Growth Arrest and Metabolic Syndrome Due to an Unclassified Hepatocellular Adenoma
MON-901 Primary Amenorrhea, Growth Arrest and Metabolic Syndrome Due to an Unclassified Hepatocellular Adenoma Open
Primary Amenorrhea, Growth Arrest and Metabolic Syndrome Due to an Unclassfied Hepatocellalar Adenoma. Background: Hepatocellular adenoma is a rare benign neoplasm, seldom ascribed as the cause of endocrine and metabolic derrangement. We h…
View article: SUN-LB36 Primary Aldosteronism Due Tosimultaneous Occurrence of Aldosteronoma in the Left Adrenal Gland and Ectopicaldosteronoma in the Liver: A Case Report
SUN-LB36 Primary Aldosteronism Due Tosimultaneous Occurrence of Aldosteronoma in the Left Adrenal Gland and Ectopicaldosteronoma in the Liver: A Case Report Open
Rationale: Ectopic adrenal tissue is the adrenal rests along the path from gonads to adrenal glands during embryogenesis. Ectopic aldosteronoma is a rare disease presented with over-production of aldosterone by the ectopic adrenocortical t…
View article: <p>Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy</p>
Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy Open
Our results demonstrated that CYP3A5 polymorphisms had important guiding roles in the treatment of IMN with tacrolimus. CYP3A5 expressers required higher daily doses of TAC to achieve the target drug concentration, but with fewer side effe…
View article: Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes
Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes Open
Background . Short-term intensive insulin therapy induces long-term glycemic remission in half of patients with newly diagnosed type 2 diabetes. The concomitant hypoglycemia needs further analysis. Methods . We collected data from three ra…
View article: The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma
The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma Open
The absence of nocturnal blood pressure (BP) decline is associated with hypertensive complications. Data regarding circadian BP patterns in patients with aldosterone-producing adenoma (APA) are limited and equivocal. We evaluated the circa…
View article: α<sub>2</sub>-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling
α<sub>2</sub>-adrenergic signaling disrupts β cell BDNF-TrkB receptor tyrosine kinase signaling Open
Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the G i/o -linked α 2 -adrenergic receptor, which upon activation suppresses insulin secretion. The use o…
View article: Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene
Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene Open
Aims/Introduction Glimepiride is a sulfonylurea known to have unique insulin mimetic and sensitizing effects. We aimed to study the efficacy of glimepiride in a patient with type A insulin resistance syndrome. Materials and Methods A 15‐ye…
View article: Angiopoietin‐like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non‐alcoholic fatty liver disease patients
Angiopoietin‐like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non‐alcoholic fatty liver disease patients Open
Aims/Introduction To explore angiopoietin‐like protein 8 ( ANGPTL ‐8) levels, and its association with hepatocellular lipid content ( HCL ) and insulin resistance in patients with different extents of non‐alcoholic fatty liver disease ( NA…
View article: Table of Contents
Table of Contents Open
View article: Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet <i>β</i>-Cell Function in Healthy Individuals
Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet <i>β</i>-Cell Function in Healthy Individuals Open
Objective . To investigate the relationship between abdominal adipose tissue distribution, β -cell function, and insulin sensitivity (IS) in a Chinese population. Methods . One hundred and eighty-eight healthy subjects (healthy group), 239…
View article: Vitamin D and its receptor regulate lipopolysaccharide‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis through the nuclear factor‐κB pathway
Vitamin D and its receptor regulate lipopolysaccharide‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis through the nuclear factor‐κB pathway Open
Aims/Introduction To investigate the effects of vitamin D and its receptor on cytokines expression and podocytes apoptosis. Materials and Methods Cultured mouse podocytes were pre‐incubated with vitamin D or transiently transfected with sm…