Explanipedia

Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations Open

Chengcheng Wang, Yu Feng, Zhiyong Zong · 2025

Colistin heteroresistance (CHR) is a growing concern in clinical settings. We aimed to investigate CHR for its prevalence in Enterobacter strains, its impact on colistin treatment, and its genetic mechanisms. We analyzed 109 non-duplicated…

The clinical impact and dissemination of carbapenemase-producing Enterobacter : a genome-based study in China Open

Shikai Wu, Yu Feng, Yanling He, Yuling Xiao, Yi Xie , et al. · 2025

Carbapenemase-producing Enterobacter (CPEn) has globally emerged to be a severe threat to human health. However, the disease spectrum, impact on affected patients’ outcomes, and transmission of CPEn are largely uncharacterized. We performe…

Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients Open

Jing Yang, Yi Zhou, Aiping Du, Zhongwei Zhang, Bo Wang , et al. · 2025

Carbapenem-resistant Klebsiella pneumoniae (CRKP) causes serious intensive care unit (ICU)-acquired infections, yet the mechanisms of microbiota-mediated colonization resistance remain unclear. We analyzed the gut microbiome and metabolic …

Draft genome of Pasteurella oralis WCHPO000540 recovered from an animal bite wound Open

Linwan Zhang, Yu Feng, Zhiyong Zong · 2025

We report the draft genome sequence of Pasteurella oralis isolated from animal bite wound secretion. The assembly comprises 30 contigs totaling 2,388,559 bp, with an N 50 of 348,256 bp and a GC content of 37.15%.

Transmission of tmexCD1-toprJ1-Positive Klebsiella pneumoniae Across Multiple Ecological Niches: A Global Epidemiological and Genomic Analysis Open

Luchao Lv, Xun Gao, Chengzhen Wang, Guolong Gao, Jie Yang , et al. · 2025

Tigecycline is one of the most critical drugs for treating Gram-negative bacterial infections; however, the emergence of the tigecycline resistance efflux pump TMexCD1-TOprJ1 poses a global health threat. The evolutionary relationships and…

Genome sequence of a carbapenem-resistant Salmonella enterica serovar Typhimurium strain 142109 Open

Linwan Zhang, Yuling Xiao, Yu Feng, Yanling He, Zhiyong Zong · 2025

We report the draft genome sequence of a carbapenem-resistant Salmonella enterica serovar Typhimurium strain isolated from a fecal sample. The strain harbors the carbapenemase gene bla NDM-5 . The assembled genome consists of 122 contigs, …

ABS0632 FUNCTIONAL CHARACTERISTICS OF GPR56+ B CELL SUBSETS AND THEIR DIAGNOSTIC POTENTIAL IN SYSTEMIC LUPUS ERYTHEMATOSUS Open

Zujian Xiong, Zhiyong Zong, Ayibaota Bahabayi, Jie Chen, Wei‐Yu Lin , et al. · 2025

Genome sequence of a lytic phage phi1_092060 targeting ST2 KL104-type Acinetobacter baumannii Open

Li Wei, Jiayuan Qin, Yu Feng, Zhiyong Zong · 2025

We describe the genome of a lytic phage isolated from sewage, which is capable of lysing ST2 KL104-type carbapenem-resistant Acinetobacter baumannii strains. The genome is 167,208 bp in length, has a guanine-cytosine (GC) content of 37%, a…

Genome sequence of the broad-host-range phage phi1_092033 against Acinetobacter baumannii Open

Jiayuan Qin, Wei Li, Yu Feng, Zhiyong Zong · 2025

We report the genome of a phage phi1_092033, isolated from sewage, which effectively lyses carbapenem-resistant Acinetobacter baumannii strains of various capsule types. phi1_092033 represents a species of genus Saclayvirus . Its genome co…

Global molecular epidemiology of the incomplete CirA protein related to cefiderocol resistance in Klebsiella pneumoniae : a genome-based study Open

Haiyan Long, Yu Feng, Zhiyong Zong · 2025

CirA is an iron transporter comprising 657 amino acids in Klebsiella pneumoniae, and incomplete CirA alone leads to reduced susceptibility to cefiderocol. We performed a genome-based analysis to study the prevalence of incomplete CirA in K…

Call for prudent use of the term hypervirulence in carbapenem-resistant Klebsiella pneumoniae Open

Yongqiang Yang, Alan McNally, Zhiyong Zong · 2025

P-285. Effects of Comorbidities and Charlson Comorbidity Index Application on Patient Outcomes in Blood and Respiratory Carbapenem-Resistant Gram-Negative Bacterial Infections Open

Jean-Francois Jabbour, Yixuan Li, Angelique E Boutzoukas, Minggui Wang, Lanjuan Li , et al. · 2025

Background Infections with carbapenem-resistant (CR) organisms are more likely in patients with comorbidities and are associated with worse prognosis. The effect of specific and multiple comorbidities on the outcomes of patients with CR in…

“Sichuanvirus”, a novel bacteriophage viral genus, able to lyse carbapenem-resistant Klebsiella pneumoniae Open

Juan Li, Qingqing Fang, Huan Luo, Feng Yan, Yu Feng , et al. · 2025

We recovered and characterized a phage of "Sichuanvirus", a novel viral genus of subfamily Stephanstirmvirinae, which is suitable for phage therapy. The discovery of this phage expands the arsenal against CRKP.

The draft genome sequence of a carbapenem-resistant Klebsiella pneumoniae strain belonging to sequence type 11 and capsular type 62 Open

Linwan Zhang, Yu Feng, Yongqiang Yang, Yanling He, Zhiyong Zong · 2024

Carbapenem-resistant Klebsiella pneumoniae (CRKP) of sequence type 11 (ST11) and capsular type KL47 or KL64 are dominant in China. We report the draft genome sequence of an ST11 bla KPC-2 -carrying CRKP strain belonging to uncommon capsula…

Global distribution of Klebsiella pneumoniae producing extended-spectrum β-lactamases in neonates Open

Ya Hu, Yu Feng, Zhiyong Zong · 2024

Ackermannviridae bacteriophage against carbapenem-resistant Klebsiella pneumoniae of capsular type 64 Open

Juan Li, Yu Feng, Huan Luo, Qingqing Fang, Yongqiang Yang , et al. · 2024

Lytic bacteriophages (phages) are promising clinically viable therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CRKP). In China, the predominant strains are those assigned to sequence type 11 and capsular type 64 (ST1…

Precise geographical distribution and call for accurate identification of histoplasmosis cases in China Open

Xinyao Liu, Zihan Zhao, Zhiyong Zong · 2024

Histoplasmosis, caused by dimorphic fungi of the Histoplasma genus,1Sepúlveda VE Márquez R Turissini DA Goldman WE Matute DR Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum.mBio. 2017; 8e01339-17Cros…

Population genomics uncovers global distribution, antimicrobial resistance, and virulence genes of the opportunistic pathogen Klebsiella aerogenes Open

Yu Feng, Yongqiang Yang, Ya Hu, Yuling Xiao, Yi Xie , et al. · 2024

Two novel Enterobacter species, Enterobacter chinensis sp. nov. and Enterobacter rongchengensis sp. nov., recovered from clinical samples carrying multiple virulence factors Open

Yanling He, Yuling Xiao, Yu Feng, Shikai Wu, Wei Li , et al. · 2024

Two Enterobacter strains 170198 T and 170250 T were isolated from clinical blood samples from distinct patients in a hospital in Chengdu, China, in 2022. These isolates were subjected to whole-genome sequencing. A phylogenomic tree based o…

Distribution of IncX3 plasmids in bacteria Open

Yu Feng, Zhiyong Zong · 2024

A recent publication concluded that the IncX3 plasmid has broad host range.1Yang QE Ma X Zeng L et al.Interphylum dissemination of NDM-5-positive plasmids in hospital wastewater from Fuzhou, China: a single-centre, culture-independent, pla…

The draft genome sequence of bla CTX-M-270 -carrying Kluyvera ascorbata isolated from human sputum Open

Lina Liu, Yu Feng, Hongxia Wen, Zhiyong Zong · 2024

Kluyvera ascorbata is recognized as an opportunistic pathogen of the Enterobacteriaceae family but remains less studied. We report the draft genome of a K. ascorbata clinical strain recovered from human sputum, comprising approximately 5.1…

Safety and efficacy of phage application in bacterial decolonisation: a systematic review Open

Qingqing Fang, Xin Yin, Yanling He, Yan Feng, Linwan Zhang , et al. · 2024

Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study Open

Jinnethe Reyes, Lauren Komarow, Liang Chen, Ge L., H. M. , et al. · 2024

Stepwise Phage Resistance Mechanisms in Carbapenem-Resistant Klebsiella Pneumoniae and Collateral Susceptibility to Phages Targeting Other Bacterial Species Open

Xin Yin, Yu Feng, Huan Luo, Qingqing Fang, Jing Yu , et al. · 2024

Clinical Outcomes of Hypervirulent Carbapenem-Resistant Klebsiella Pneumoniae Infection: A Cohort Study with Multiplex Analyses in China Open

Ya Hu, Qingqing Fang, Linwan Zhang, Yanling He, Yu Feng , et al. · 2024

The draft genome sequence of bla IMP-4 -carrying Enterobacter soli isolated from human blood Open

Yu Feng, Zhiyong Zong · 2023

Enterobacter soli is a Gram-negative rod characterized by its motile, non-spore-forming, and facultatively anaerobic nature. In this study, strain 140044, identified as Enterobacter soli , was isolated from human blood. The strain was sequ…

Draft genome sequence of an Atlantibacter hermannii clinical strain isolated from human muscle tissue Open

Feng Yan, Yu Feng, Zhiyong Zong · 2023

Atlantibacter hermannii is a species of the family Enterobacteriaceae and a rare opportunistic pathogen. The draft genome sequence of an Atlantibacter hermannii clinical strain that had been isolated from infected muscle tissue was obtaine…

2189. Colistin Heteroresistance in Enterobacter due to Base Heterozygosity at Certain phoPQ Locations Open

Chengcheng Wang, Yu Feng, Zhiyong Zong · 2023

Background Enterobacter species are major nosocomial pathogens, and the clinical implications and mechanisms of colistin heteroresistance (CHR) in Enterobacter remain unclear. Methods We used the population analysis profile (PAP) assay to …

720. The clinical outcomes of hypervirulent carbapenem-resistant Klebsiella pneumoniae (CRKP) infection were not poorer than that of classical CRKP infection Open

Ya Hu, Zhiyong Zong · 2023

Background Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) was superbug for patients. Despite the high resistance and virulence, the clinical outcomes of hv-CRKP induced infections were not ever measured before. Methods …

2772. Isolation and Characterization of Lytic Bacteriophages Targeting Clinical Isolates of genus Enterobacter Open

Yanling He, Zhiyong Zong · 2023

Background Enterobacter strains are part of the human intestinal commensal microflora and important pathogens of hospital-acquired infections,such as bacteremia, lower respiratory tract infections, and urinary tract infections. In an era o…

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