Zhiyong Yuan
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View article: Water consumption contributes to maternal PFAS exposure: From source to metabolic perturbations
Water consumption contributes to maternal PFAS exposure: From source to metabolic perturbations Open
View article: Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity
Architecture and mechanism of a dual-enzyme retron system in prokaryotic immunity Open
View article: Safety Assessment and Probiotic Potential of a Novel Species Lactobacillus xujianguonis
Safety Assessment and Probiotic Potential of a Novel Species Lactobacillus xujianguonis Open
Background: Some lactobacilli strains have been documented to cause bacteremia and sepsis in immunocompromised or critically ill hospitalized patients, challenging the universally presumed safety of lactobacilli. Therefore, strain-specific…
View article: Hypothyroidism is associated with radiation-induced pulmonary fibrosis
Hypothyroidism is associated with radiation-induced pulmonary fibrosis Open
Hypothyroidism is significantly associated with RIPF susceptibility in breast cancer patients treated with postoperative IMRT. These results highlight the potential of thyroid function as a modifiable risk factor in RIPF and underscore the…
View article: OX40/OX40L: A New Target for Tumor Immunotherapy and Its Clinical Research Progress
OX40/OX40L: A New Target for Tumor Immunotherapy and Its Clinical Research Progress Open
The OX40 and OX40L signaling axis represents a key costimulatory pathway in the TNF and TNFR superfamilies. In tumor immunotherapy, OX40L binds to OX40 on activated T cells to promote T cell expansion and cytokine production while inhibiti…
View article: Large Language Models as Virtual Survey Respondents: Evaluating Sociodemographic Response Generation
Large Language Models as Virtual Survey Respondents: Evaluating Sociodemographic Response Generation Open
Questionnaire-based surveys are foundational to social science research and public policymaking, yet traditional survey methods remain costly, time-consuming, and often limited in scale. This paper explores a new paradigm: simulating virtu…
View article: CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer Open
Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therap…
View article: Transcriptomic Profiling Reveals Predictive Markers of Response to Concurrent Chemoradiotherapy plus Immune Checkpoint Inhibition in Cervical Cancer
Transcriptomic Profiling Reveals Predictive Markers of Response to Concurrent Chemoradiotherapy plus Immune Checkpoint Inhibition in Cervical Cancer Open
Background Concurrent chemoradiotherapy (CCRT) combined with immune checkpoint inhibition has emerged as a promising treatment for locally advanced cervical cancer (LACC), yet approximately 30% of patients fail to achieve complete response…
View article: Global, regional, and national epidemiology of childhood epilepsy from 1990 to 2021: a systematic study based on the GBD 2021
Global, regional, and national epidemiology of childhood epilepsy from 1990 to 2021: a systematic study based on the GBD 2021 Open
Childhood epilepsy remains a growing global health concern, with an increasing incidence despite ongoing declines in mortality and DALYs. Although advancements in healthcare have contributed to reduced epilepsy-related deaths and DALYs ove…
View article: Consolidative stereotactic radiotherapy for oligo-residual non-small cell lung cancer after first-line chemoimmunotherapy: A single-arm, phase 2 trial from China
Consolidative stereotactic radiotherapy for oligo-residual non-small cell lung cancer after first-line chemoimmunotherapy: A single-arm, phase 2 trial from China Open
Background Retrospective evidence indicated potential survival benefit of consolidative stereotactic radiotherapy (SRT) in patients with metastatic driver mutation-negative non-small cell lung cancer (NSCLC) harboring oligo-residual diseas…
View article: The study on myocardial protection of <italic>Bushen Huoxue Compound</italic>(补肾活血复方) in rats with heart failure after myocardial infarction
The study on myocardial protection of <italic>Bushen Huoxue Compound</italic>(补肾活血复方) in rats with heart failure after myocardial infarction Open
View article: The efficacy and safety of neoadjuvant and adjuvant chemo(radio)therapy combined with surgery in patients with locally advanced rectal cancer harboring defective mismatch repair system: a large-scale multicenter propensity score analysis
The efficacy and safety of neoadjuvant and adjuvant chemo(radio)therapy combined with surgery in patients with locally advanced rectal cancer harboring defective mismatch repair system: a large-scale multicenter propensity score analysis Open
Background For locally advanced rectal cancer (LARC) with a deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H), particularly in patients not eligible for immunotherapy, the optimal treatment remains undetermined. This s…
View article: An anterior mediastinal cystic lesion pathologically confirmed as a mediastinal pancreatic pseudocyst after thoracoscopic resection: a rare case report and literature review
An anterior mediastinal cystic lesion pathologically confirmed as a mediastinal pancreatic pseudocyst after thoracoscopic resection: a rare case report and literature review Open
Background Mediastinal lesions have diverse etiologies, with thymoma, cystic teratoma, and lymphoma being relatively prevalent. In contrast, a pancreatic pseudocyst within the mediastinum is exceedingly rare and can often be mistaken for a…
View article: Low-dose Radiation Therapy Concurrent With Atezolizumab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer: 3-Year Follow-up of a Multicenter, Single-arm, Phase 2 Trial (MATCH)
Low-dose Radiation Therapy Concurrent With Atezolizumab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer: 3-Year Follow-up of a Multicenter, Single-arm, Phase 2 Trial (MATCH) Open
These findings suggest that upfront LDRT concurrent with atezolizumab plus chemotherapy was effective and tolerable as first-line treatment for ES-SCLC, warranting further verification in randomized controlled trials.
View article: Research on Immersive Panoramic Intelligent Mining Remote Control System
Research on Immersive Panoramic Intelligent Mining Remote Control System Open
In addressing the challenges posed by constrained monitoring vision and delayed communication in fully mechanized mining operations within coal mines, the development of an immersive, panoramic intelligent mining remote control system has …
View article: Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons
Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons Open
Periodontitis, a prevalent chronic inflammatory disease, profoundly impacts both quality of life and overall health. Clinical studies have suggested a correlation between periodontitis and sleep deficiency, but the underlying mechanisms in…
View article: Figure S2 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S2 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Schematic of HCC mouse models and serum analysis
View article: Figure S6 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S6 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 condensates promote HCC cell migration and invasion
View article: Figure S4 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S4 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 knockout inhibits HCC cell migration and invasion
View article: Figure S11 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S11 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 facilitates c-Jun targets expression.
View article: Figure S10 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S10 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Identification of CRTC2–YTHDF2 co-condensate m6A-RNAs.
View article: Figure S13 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S13 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 promotes Lenvatinib resistance in HCC.
View article: Figure S1 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S1 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Correlation analysis of CRTC2 expression with CNA
View article: Figure S9 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S9 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 promotes HCC progression dependent on YTHDF2.
View article: Figure S8 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S8 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 serves as a scaffold protein to recruit YTHDF2 into condensates.
View article: Figure S3 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S3 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Knockout of CRTC2 impairs proliferation of HCC cells.
View article: Figure S14 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S14 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Schematic of AAV8.sgCRTC2 gene therapy in HCC mouse model.
View article: Data from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Data from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
As the third most common cause of cancer-related mortality, hepatocellular carcinoma (HCC) is a global health concern. Despite its prevalence, treatment options are limited, underscoring the need to identify potential therapeutic targets a…
View article: Table S1 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Table S1 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
Relationship between baseline and clinical characteristics of the patient and CRTC2 expression
View article: Figure S5 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance
Figure S5 from CRTC2 Forms Co-Condensates with YTHDF2 That Enhance Translational Efficiency of m<sup>6</sup>A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance Open
CRTC2 condensates promote HCC initiation and progression in vivo and in vitro.