Yun‐Zhi Feng
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View article: Engineered immune-driven theranostics for clinical cardiology
Engineered immune-driven theranostics for clinical cardiology Open
Immunotherapy for cardiovascular diseases (CVDs) holds great promise for precision management by modulating localized immune-inflammatory responses. The interplay between focal cardiovascular pathology and panvascular disease, necessitates…
View article: I-OPV: Synergistic Macrophage Immunomodulation In Pulpitis
I-OPV: Synergistic Macrophage Immunomodulation In Pulpitis Open
Aim or purpose: This study evaluates the biocompatibility and immunomodulatory effects of I-OPV on macrophages, exploring its potential for synergistic antibacterial-regenerative therapy in pulpitis. Materials and methods: Approved by the …
View article: Application of <i>Ng</i> Ago-mediated genome editing in <i>Mycobacterium smegmatis</i>
Application of <i>Ng</i> Ago-mediated genome editing in <i>Mycobacterium smegmatis</i> Open
Mycobacterium smegmatis is nonpathogenic and fast-growing and is usually used as a model species of Mycobacterium . Studying basic metabolic mechanisms is crucial for accelerating mycobacterial research. Although several tools for genome e…
View article: Revealing the causal relationship between HBV and HCV infection and liver cirrhosis by Mendelian randomization
Revealing the causal relationship between HBV and HCV infection and liver cirrhosis by Mendelian randomization Open
This research highlights a causal relationship between HBV and AST levels, suggesting that monitoring AST levels can indicate the extent of liver damage caused by chronic HBV infection. Additionally, causal connections were established bet…
View article: An Investigation into the Evolutionary Characteristics and Expression Patterns of the Basic Leucine Zipper Gene Family in the Endangered Species Phoebe bournei Under Abiotic Stress Through Bioinformatics
An Investigation into the Evolutionary Characteristics and Expression Patterns of the Basic Leucine Zipper Gene Family in the Endangered Species Phoebe bournei Under Abiotic Stress Through Bioinformatics Open
The bZIP gene family play a crucial role in plant growth, development, and stress responses, functioning as transcription factors. While this gene family has been studied in several plant species, its roles in the endangered woody plant Ph…
View article: Bioinformatics Analysis Reveals the Evolutionary Characteristics of the Phoebe bournei ARF Gene Family and Its Expression Patterns in Stress Adaptation
Bioinformatics Analysis Reveals the Evolutionary Characteristics of the Phoebe bournei ARF Gene Family and Its Expression Patterns in Stress Adaptation Open
Auxin response factors (ARFs) are pivotal transcription factors that regulate plant growth, development, and stress responses. Yet, the genomic characteristics and functions of ARFs in Phoebe bournei remain undefined. In this study, 25 PbA…
View article: Genome-Wide Analysis of CPP Transcription Factor Family in Endangered Plant Phoebe bournei and Its Response to Adversity
Genome-Wide Analysis of CPP Transcription Factor Family in Endangered Plant Phoebe bournei and Its Response to Adversity Open
The CPP gene family comprises transcription factor genes containing a conserved CRC domain, which is mainly involved in plant development and evolution. Although CPP genes have been widely studied in many plants, little is known about them…
View article: Phylogenetic and Expression Analysis of SBP-Box Gene Family to Enhance Environmental Resilience and Productivity in Camellia sinensis cv. Tie-guanyin
Phylogenetic and Expression Analysis of SBP-Box Gene Family to Enhance Environmental Resilience and Productivity in Camellia sinensis cv. Tie-guanyin Open
Tieguanyin tea, a renowned oolong tea, is one of the ten most famous teas in China. The Squamosa Promoter Binding Protein (SBP)-box transcription factor family, widely present in plants, plays a crucial role in plant development, growth, a…
View article: Impact of Lipid-Lowering Therapy on Pancreatic Health: Insights from Mendelian Randomization
Impact of Lipid-Lowering Therapy on Pancreatic Health: Insights from Mendelian Randomization Open
Pancreatic diseases, usually including various pancreatitis, pancreatic cancer and pancreatic cysts, present great challenges to the global health care system. Abnormal lipid profiles are common in these pancreatic diseases, suggesting the…
View article: The role of circulating polyunsaturated fatty acids in mediating the effect of BMI on leukocyte telomere length: analysis using Mendelian randomization
The role of circulating polyunsaturated fatty acids in mediating the effect of BMI on leukocyte telomere length: analysis using Mendelian randomization Open
View article: Development and Validation of Chinese Version of Dental Pain Screening Questionnaire
Development and Validation of Chinese Version of Dental Pain Screening Questionnaire Open
View article: The Effect of obesity on dental caries: A mendelian randomization study
The Effect of obesity on dental caries: A mendelian randomization study Open
Background Clinical and retrospective studies suggest obesity increases the risk of dental caries, but causal mechanisms remain unclear. We employed the Mendelian randomization (MR) method to explore obesity's potential causal link to dent…
View article: Comparison of Easydo Activator, ultrasonic and needle irrigation techniques on sealer penetration and smear layer removal in vitro
Comparison of Easydo Activator, ultrasonic and needle irrigation techniques on sealer penetration and smear layer removal in vitro Open
The effects of Easydo Activator (EA), a new sonic irrigation system, on sealer penetration at the root apex were compared to needle irrigation (NI) and passive ultrasonic irrigation (PUI) in this study. Forty-two single-rooted teeth were p…
View article: Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study
Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study Open
Background: Regarding past epidemiological studies, there has been disagreement over whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of this study was to determine the causative links between geneti…
View article: Causal effects of the gut microbiome on COVID-19 susceptibility and severity: a two-sample Mendelian randomization study
Causal effects of the gut microbiome on COVID-19 susceptibility and severity: a two-sample Mendelian randomization study Open
Background The coronavirus disease 2019 (COVID-19) caused a global pandemic, with potential severity. We aimed to investigate whether genetically predicted gut microbiome is associated with susceptibility and severity of COVID-19 risk. Met…
View article: Factorial structure and measurement invariance of the Chinese version of the Oral Health Impact Profile-14 among clinical populations and non-clinical populations: an evidence for public oral investigations
Factorial structure and measurement invariance of the Chinese version of the Oral Health Impact Profile-14 among clinical populations and non-clinical populations: an evidence for public oral investigations Open
View article: Cross-cultural adaptation and psychometric properties of the Mainland Chinese version of the manchester orofacial pain disability scale (MOPDS) among college students
Cross-cultural adaptation and psychometric properties of the Mainland Chinese version of the manchester orofacial pain disability scale (MOPDS) among college students Open
Background Orofacial pain (OFP) is a highly prevalent disorder in mainland China that predisposes to an associated physical and psychological disability. There is lack of a good properties mainland Chinese version of instrument to examine …
View article: Chitosan nanoparticles for sustained release of metformin and its derived synthetic biopolymer for bone regeneration
Chitosan nanoparticles for sustained release of metformin and its derived synthetic biopolymer for bone regeneration Open
Background: There are considerable socioeconomic costs associated with bone defects, making regenerative medicine an increasingly attractive option for treating them. Chitosan is a natural biopolymer; it is used in approaches for sustained…
View article: Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction
Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction Open
Objectives The purpose of this study was to evaluate available evidence on the association between the human oral microbiota and coronavirus disease 2019 (COVID-19) and summarize relevant data obtained during the pandemic. Methods We searc…
View article: Clinical application and efficacy of mesenchymal stem cells in the regeneration of periodontal defects: a systematic review and meta-analysis of randomized controlled trials
Clinical application and efficacy of mesenchymal stem cells in the regeneration of periodontal defects: a systematic review and meta-analysis of randomized controlled trials Open
Eligibility criteria: RCTs with tissue engineering treatment using stem cells applied to the experimental group
View article: Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering
Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering Open
View article: Development, validation and psychometric evaluation of the Chinese version of the biopsychosocial impact scale in orofacial pain patients
Development, validation and psychometric evaluation of the Chinese version of the biopsychosocial impact scale in orofacial pain patients Open
Background The objective of this study was to develop the Chinese version of the biopsychosocial impact scale (BPIm-S) to assess functional limitation and psychosocial distress in orofacial pain (OFP) patients in mainland China, and invest…
View article: Oral Health-Related Quality of Life among Chinese Chronic Orofacial Pain Patients with Psychological Health Problems: A Moderated Mediation Model
Oral Health-Related Quality of Life among Chinese Chronic Orofacial Pain Patients with Psychological Health Problems: A Moderated Mediation Model Open
Psychological therapies are important for comprehensive chronic orofacial pain (COFP) treatment. This study is to validate the effects of psychological factors on oral health-related quality of life (OHRQoL) among COFP patients in China. P…
View article: Prevotella genus and its related NOD-like receptor signaling pathway in young males with stage III periodontitis
Prevotella genus and its related NOD-like receptor signaling pathway in young males with stage III periodontitis Open
Background As periodontitis progresses, the oral microbiota community changes dynamically. In this study, we evaluated the dominant bacteria and their roles in the potential pathway in young males with stage III periodontitis. Methods 16S …
View article: Comparison of sealer penetration of sonic activation versus conventional needle irrigation: a systematic review and meta-analysis of randomized controlled trials
Comparison of sealer penetration of sonic activation versus conventional needle irrigation: a systematic review and meta-analysis of randomized controlled trials Open
View article: The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis
The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis Open
Objective Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified the dominant bacteria and the potential pathway in young women with stage-III periodontitis. Materials and methods Samples of subging…
View article: The expression and methylation of PITX genes is associated with the prognosis of head and neck squamous cell carcinoma
The expression and methylation of PITX genes is associated with the prognosis of head and neck squamous cell carcinoma Open
Background: The PITX gene family, comprising PITX1 , PITX2 , and PITX3 , is critical in organogenesis and has been evolutionary conserved in animals. PITX genes are associated with the advanced progression and poor prognosis of multiple ca…
View article: The Chinese version of the Oral Health Impact Profile-14 (OHIP-14) questionnaire among college students: factor structure and measurement invariance across genders
The Chinese version of the Oral Health Impact Profile-14 (OHIP-14) questionnaire among college students: factor structure and measurement invariance across genders Open
Background The Oral Health-related Quality of Life (OHRQoL) is a multi-dimensional concept commonly used to examine the impact of health status on quality of life, and the Oral Health Impact Profile-14 (OHIP-14) questionnaire is a good sel…
View article: Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats
Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats Open
Objectives To evaluate the long-term therapeutic effect of EASYDO ACTIVATOR, passive ultrasonic irrigation, and needle irrigation in experimental apical periodontitis in rats. Materials and methods Sprague-Dawley male rats were used to pro…
View article: Traditional Chinese medicine promotes bone regeneration in bone tissue engineering
Traditional Chinese medicine promotes bone regeneration in bone tissue engineering Open