Zhichao Zhang
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View article: The relationship between OPLL and metabolic disorders
The relationship between OPLL and metabolic disorders Open
View article: HexaDream: hexaview prior and constraint for text to 3D creation
HexaDream: hexaview prior and constraint for text to 3D creation Open
The burgeoning field of text-to-3D synthesis offers transformative potential in diverse domains such as computer-aided design, gaming, virtual reality, and artistic creation. However, the generation struggles with issues of inconsistency a…
View article: Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy: a retrospective study
Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy: a retrospective study Open
View article: YTHDF1 regulates YTHDF2 stability via m6A-dependent mechanisms in hepatocellular carcinoma: insights from in vitro, in vivo, and multi-cohort clinical studies
YTHDF1 regulates YTHDF2 stability via m6A-dependent mechanisms in hepatocellular carcinoma: insights from in vitro, in vivo, and multi-cohort clinical studies Open
YTHDF1 drives HCC progression through m6A-mediated stabilization of YTHDF2, revealing their functional synergy. Their combined spatial and expression profiles offer a superior prognostic biomarker, suggesting novel therapeutic targets.
View article: Optimizing remote sensing methods for forest stand density estimation in mountainous areas: a UAV-sentinel-2 synergy
Optimizing remote sensing methods for forest stand density estimation in mountainous areas: a UAV-sentinel-2 synergy Open
View article: Exploring the impact of emergency risk information on construction workers’ emergency information behavior: insights from confirmatory and exploratory PLS-SEM analyses
Exploring the impact of emergency risk information on construction workers’ emergency information behavior: insights from confirmatory and exploratory PLS-SEM analyses Open
Drawing on risk perception and information adoption theories, this study develops a structural equation model to examine the factors influencing emergency information behavior (EIB). The model includes risk information characteristics (RIC…
View article: Graph Fractional Hilbert Transform: Theory and Application
Graph Fractional Hilbert Transform: Theory and Application Open
The graph Hilbert transform (GHT) is a key tool in constructing analytic signals and extracting envelope and phase information in graph signal processing. However, its utility is limited by confinement to the graph Fourier domain, a fixed …
View article: Exploring Policy Feasibility Using Social Simulation Games: A Case Study of Floor Area Ratio Trading in China
Exploring Policy Feasibility Using Social Simulation Games: A Case Study of Floor Area Ratio Trading in China Open
Floor area ratio (FAR), the ratio of a building’s total floor area to its land area, is a critical urban planning metric. The FAR control, a government-regulated mechanism for land resource allocation, plays a crucial role in balancing pri…
View article: A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control
A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control Open
Ribosome biogenesis is an essential and tightly regulated process linked to cell proliferation and growth. However, its regulatory mechanisms in oomycetes, a group of organisms with significant agricultural and ecological importance, remai…
View article: AI and stroke rehabilitation: The past, present and future
AI and stroke rehabilitation: The past, present and future Open
View article: The new definition of metabolic syndrome including hyperuricemia improves its prognostic value: results from NHANES database
The new definition of metabolic syndrome including hyperuricemia improves its prognostic value: results from NHANES database Open
The inclusion of hyperuricemia in the MetS criteria could identify a larger proportion of individuals at metabolic risk, thereby facilitating early management to prevent long-term adverse events.
View article: Genetic Pattern and Demographic History of Orange‐Spotted Grouper (<i>Epinephelus coioides</i>) in the South China Sea by the Influence of Pleistocene Climatic Oscillations
Genetic Pattern and Demographic History of Orange‐Spotted Grouper (<i>Epinephelus coioides</i>) in the South China Sea by the Influence of Pleistocene Climatic Oscillations Open
Orange‐spotted groupers ( Epinephelus coioides ) are commercially important fish species that inhabit coral reef areas and are distributed across tropical coastal regions throughout the Indo‐West Pacific Oceans. This study aims to assess t…
View article: Evaluation of IgG binding capability to SARS-CoV-2 variants in early COVID-19 convalescent sera using an indirect ELISA
Evaluation of IgG binding capability to SARS-CoV-2 variants in early COVID-19 convalescent sera using an indirect ELISA Open
View article: Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis
Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis Open
Objectives Unlike other diseases, cancer is not just a genome disease but should broadly be viewed as a disease of the cellular machinery. Therefore, integrative multifaceted approaches are crucial to understanding the complex nature of ca…
View article: Integrating metagenomics and untargeted metabolomics to analyze the relationship between microbial dynamics and non-volatile metabolomic profiles in plant-derived microbial fuel cells (MFCs)
Integrating metagenomics and untargeted metabolomics to analyze the relationship between microbial dynamics and non-volatile metabolomic profiles in plant-derived microbial fuel cells (MFCs) Open
A study investigating the microbial dynamics conducted for the first time to employ metagenomics and non-targeted metabolomics to MFCs.
View article: Microplastics Pollution in Mariculture Areas with Geographic Features
Microplastics Pollution in Mariculture Areas with Geographic Features Open
View article: Alternating Copolymerization of (Substituted) Styrenes with Carbon Monoxide Catalyzed by Mononuclear and Binuclear Palladium Complexes Supported by Imino-Pyridine Frameworks
Alternating Copolymerization of (Substituted) Styrenes with Carbon Monoxide Catalyzed by Mononuclear and Binuclear Palladium Complexes Supported by Imino-Pyridine Frameworks Open
View article: Correction: RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy
Correction: RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy Open
View article: RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy
RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy Open
The pursuit of innovative therapeutic strategies in oncology remains imperative, given the persistent global impact of cancer as a leading cause of mortality. Immunotherapy is regarded as one of the most promising techniques for systemic c…
View article: Field investigation of the feasibility of MICP for Mitigating Natural Rainfall-Induced erosion in gravelly clay slope
Field investigation of the feasibility of MICP for Mitigating Natural Rainfall-Induced erosion in gravelly clay slope Open
Rainfall-induced erosion on slopes is a prevalent natural process leading to soil loss. One promising application of microbially induced carbonate precipitation (MICP) is to mitigate rainfall-induced erosion. Conducting field tests is an e…
View article: A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage Open
View article: De Novo Rational Design of Peptide‐Based Protein–Protein Inhibitors (Pep‐PPIs) Approach by Mapping the Interaction Motifs of the PP Interface and Physicochemical Filtration: A Case on p25‐Cdk5‐Mediated Neurodegenerative Diseases
De Novo Rational Design of Peptide‐Based Protein–Protein Inhibitors (Pep‐PPIs) Approach by Mapping the Interaction Motifs of the PP Interface and Physicochemical Filtration: A Case on p25‐Cdk5‐Mediated Neurodegenerative Diseases Open
Protein–protein interactions, or PPIs, are a part of every biological activity and have been linked to a number of diseases, including cancer, infectious diseases, and neurological disorders. As such, targeting PPIs is considered a strateg…
View article: Graph Linear Canonical Transform Based on CM-CC-CM Decomposition
Graph Linear Canonical Transform Based on CM-CC-CM Decomposition Open
The graph linear canonical transform (GLCT) is presented as an extension of the graph Fourier transform (GFT) and the graph fractional Fourier transform (GFrFT), offering more flexibility as an effective tool for graph signal processing. I…
View article: Neutralization and Binding Capability of SARS-CoV-2 Variants by/of IgG Antibodies of Early COVID-19 Convalescent Inactivated Sera based on Indirect ELISA
Neutralization and Binding Capability of SARS-CoV-2 Variants by/of IgG Antibodies of Early COVID-19 Convalescent Inactivated Sera based on Indirect ELISA Open
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a single stranded RNA virus which has resulted in the Coronavirus Disease 2019 (COVID-19) pandemic and has infected millions of people all over the world. SARS-CoV-2 has been …
View article: De Novo Design of Hsp70 Inhibitors with Objective Reinforced Generative Adversarial Networks (ORGAN) and Docking
De Novo Design of Hsp70 Inhibitors with Objective Reinforced Generative Adversarial Networks (ORGAN) and Docking Open
The rise of deep learning technology has brought paradigm shift to drug design, significantly reducing the economic and time burden in the drug development process. We herein report the Objective Reinforced Generative Adversarial Networks …
View article: METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression
METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression Open
View article: Sparse Point Cloud Registration Network with Semantic Supervision in Wilderness Scenes
Sparse Point Cloud Registration Network with Semantic Supervision in Wilderness Scenes Open
The registration of laser point clouds in complex conditions in wilderness scenes is an important aspect in the research field of autonomous vehicle navigation. It serves as the foundation for solving problems such as environment reconstru…
View article: Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy
Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy Open
Hsp27 is a member of the small heat-shock proteins (sHSPs) - the known cellular line of defence against abnormal protein folding behaviors. Nevertheless, its upregulation is linked to a variety of pathological disorders, including several …
View article: Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance Open
Introduction Estrogen receptor (ER) positive patients compromise about 70% of breast cancers. Tamoxifen, an antagonist of ERα66 (the classic ER), is the most effective and the standard first-line drug. However, its efficacy is limited by t…
View article: Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study
Total bilirubin level on postoperative day 3 in predicting clinically relevant pancreatic fistula after pancreaticoduodenectomy : a retrospective study Open
Background: The prevalence of clinically relevant postoperative pancreatic fistulas (CR-POPF) following pancreaticoduodenectomy (PD) is relatively high. Most studies on the prediction of CR-POPF are limited to pre-operation, while there ar…