Explanipedia

Engineered Multicolor NIR‐I/II Fluorescent Proteins for Precise In Vivo Visualization and Imaging‐Guided Surgery Open

Zetao Dang, Shengjie Ma, Bin Sun, Yijing Du, Zhiding Wang , et al. · 2025

Even though existing near‐infrared probes have successfully achieved deep tissue imaging with high contrast, it remains challenging to image many species simultaneously under complicated biological conditions. We rationally design and synt…

Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis Open

Likai Yu, Zishan Su, Di Tian, Sifeng Liu, Zhang Li , et al. · 2025

Background External mechanical stress plays a pivotal role in the pathogenesis of knee osteoarthritis. Piezo1 can sense mechanical stress changes on the surface of various cell types and convert them into bioelectrical signals to regulate …

Plasma IL-22 and Claudin-4 in obstructive sleep apnea: A pilot observational study linking mucosal barrier biomarkers to disease severity Open

Dan Liu, Yan Wang, Zhiding Wang, Jing Feng · 2025

Plasma IL-22 and CLDN4 were associated with OSA severity and mucosal barrier alterations. Their co-regulation aligns with preclinical models of IH-driven barrier adaptation, supporting further mechanistic investigation. The diagnostic pote…

Albumin Encapsulation of Cyanine Dye for High-Performance NIR-II Imaging-Guided Photodynamic Therapy Open

Lang Bai, Yiyang Jia, Zihan Wang, Zhiding Wang, Yunlong Jia , et al. · 2025

Albumin encapsulation is a powerful strategy for drug delivery, yet its potential has not been fully explored for photodynamic therapy (PDT) agents. Cl-containing near-infrared (NIR) cyanine dyes are intrinsically PDT agents and tend to co…

Tim-3 promotes viral infection by suppressing USP25-TRAF3-IRF7 signaling pathway Open

Lin Du, Jinjie Chen, Chunxiao Du, Junrui Chen, Chaoxiang Wang , et al. · 2024

Tim-3, an immune checkpoint inhibitor, plays key roles in maintaining immune homeostasis and is involved in viral evasion. However, the precise role of Tim-3 in viral infection remains to be determined. USP25 is one of the deubiquitinating…

5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination Open

Zhenfang Gao, Yang Gao, Yuxiang Li, Jie Zhou, Ge Li , et al. · 2024

TCR β chain repertoire characteristic between healthy human CD4+ and CD8+ T cells Open

Ge Li, Yaqiong Chen, Yinji Liu, Zhenfang Gao, Ruiyan Jia , et al. · 2024

T cell is vital in the adaptive immune system, which relays on T-cell receptor (TCR) to recognize and defend against infection and tumors. T cells are mainly divided into well-known CD4+ and CD8+ T cells, which can recognize short peptide …

Tim-3 Knockout Exacerbates Chronic Restraint Stress Induced Depression by Enhancing Neuroinflammation Open

Ge Li, Meng Liang, Chunxiao Du, Lin Du, Junrui Chen , et al. · 2024

Chronic Breathlessness in Obstructive Sleep Apnea and the Use of Lymphocyte Parameters to Identify Overlap Syndrome among Patients Open

Dan Liu, Zhiding Wang, Yan Zhuang, Yan Wang, Jing Zhang , et al. · 2023

Little is known about the distribution of etiology in obstructive sleep apnea (OSA) combined with chronic breathlessness. A significant portion of patients in this group have so-called “overlap syndrome (OVS)”, characterized by chronic obs…

Negative Regulation of RIG-I by Tim-3 Promotes H1N1 Infection Open

Qingzhu Shi, Ge Li, Shuaijie Dou, Lili Tang, Chunmei Hou , et al. · 2022

The mechanisms by which retinoic acid-inducible gene I (RIG-I), a critical RNA virus sensor, is regulated in many biological and pathological processes remain to be determined. Here, we demonstrate that T cell immunoglobulin and mucin prot…

Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II Open

Lili Tang, Ge Li, Yang Zheng, Chunmei Hou, Yang Gao , et al. · 2022

Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and contributes to immune tolerance. However, the mechanisms by which Tim-3 induces immune tolerance remain to be determined. Major histocompatibility complex I…

Acute Myeloid Leukemia Epigenetic Immune Escape From Nature Killer Cells by ICAM-1 Open

Yang Xiao, Jinghong Chen, Jia Wang, Wei Guan, Mengzhen Wang , et al. · 2021

Acute myeloid leukemia (AML), a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions, and epigenetic modification, while the mechanism is not clearly understood. H…

Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation Open

Ge Li, Lili Tang, Chunmei Hou, Zhiding Wang, Yang Gao , et al. · 2021

Viral encephalitis is the most common cause of encephalitis. It is responsible for high morbidity rates, permanent neurological sequelae, and even high mortality rates. The host immune response plays a critical role in preventing or cleari…

One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia Open

Zhiding Wang, Jinghong Chen, Mengzhen Wang, Linlin Zhang, Li Yu · 2021

T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eli…

MR1-restricted T cells: the new dawn of cancer immunotherapy Open

Zhiding Wang, Mengzhen Wang, Jinghong Chen, Linlin Zhang, Li Zhang , et al. · 2020

Cancer immunotherapy has recently undergone rapid development into a validated therapy for clinical use. The adoptive transfer of engineered autologous T cells, such as chimeric antigen receptor (CAR) T cells, has been remarkably successfu…

The protective role of miR-223 in sepsis-induced mortality Open

Dan Liu, Zhiding Wang, Huijuan Wang, Feifei Ren, Yanqin Li , et al. · 2020

T cell immunoglobulin and mucin domain protein 3 inhibits glycolysis in RAW 264.7 macrophages through Hexokinase 2 Open

Jiacheng Zhang, Chunmei Hou, Shuaijie Dou, Ge Li, Zhiding Wang , et al. · 2020

T cell immunoglobulin and mucin domain‐3 (Tim‐3), an immune checkpoint molecule, plays critical roles in maintaining innate immune homeostasis; however, the mechanisms underlying these roles remain to be determined. Here, we determined tha…

Acute myeloid leukemia immune escape by epigenetic CD48 silencing Open

Zhiding Wang, Yang Xiao, Wei Guan, Mengzhen Wang, Jinghong Chen , et al. · 2020

Acute myeloid leukemia (AML) is a malignant disorder of hemopoietic stem cells. AML can escape immunosurveillance of natural killer (NK) by gene mutation, fusions and epigenetic modification. The mechanism of AML immune evasion is not clea…

The E3 ubiquitin ligase Itch is required for B-cell development Open

Xiaoling Liu, Yu Zhang, Yinxiang Wei, Zhiding Wang, Gaizhi Zhu , et al. · 2019

Monoclonal antibody against human Tim‐3 enhances antiviral immune response Open

Ge Li, Chunmei Hou, Shuaijie Dou, Jiacheng Zhang, Yanling Zhang , et al. · 2018

T cell immunoglobulin and mucin domain protein 3 (Tim‐3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim‐3 is related to immune exhaustion in tumour and viral infection. To overcome…

Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice Open

Xiaoqian Wang, Yu Zhang, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu , et al. · 2017

The interleukin (IL)‑12 family cytokines have been examined as therapeutic targets in the treatment of several autoimmune diseases. Our previous study showed that a novel IL‑12 family cytokine, IL‑39 (IL‑23p19/Ebi3) mediates inflammation i…

Negative regulation of Nod‐like receptor protein 3 inflammasome activation by T cell Ig mucin‐3 protects against peritonitis Open

Wei Wang, Qingzhu Shi, Shuaijie Dou, Li Ge, Xinhui Shi , et al. · 2017

Summary The Nod‐like receptor protein 3 ( NLRP 3) inflammasome plays roles in host defence against invading pathogens and in the development of autoimmune damage. Strict regulation of these responses is important to avoid detrimental effec…

Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2 Open

Zhiding Wang, Dejun Sun, Guojiang Chen, Ge Li, Shuaijie Dou , et al. · 2017

Foxd3 suppresses interleukin‐10 expression in B cells Open

Yu Zhang, Zhiding Wang, Xiao He, Xiaoling Liu, Gaizhi Zhu , et al. · 2016

Summary Interleukin‐10‐positive (IL‐10 + ) regulatory B (Breg) cells play an important role in restraining excessive inflammatory responses by secreting IL‐10. However, it is still unclear what key transcription factors determine Breg cell…

Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis Open

Xiaoling Liu, Yu Zhang, Zhiding Wang, Xiaoqian Wang, Gaizhi Zhu , et al. · 2016

Cell apoptosis plays a critical role in initiation and progression of tumor and autoimmune diseases, resistance and susceptibility to various therapeutic agents. Our previous study showed that metabotropic glutamate receptor 3 (Grm3) may b…

Interleukin (IL)-39 [IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice Open

X. Wang, Xueru Liu, Yu Zhang, Zhiding Wang, Guoqiang Zhu , et al. · 2016

Summary Interleukin (IL)-12 family cytokines play critical roles in autoimmune diseases. Our previous study has shown that IL-23p19 and Epstein–Barr virus-induced 3 (Ebi3) form a new IL-12 family heterodimer, IL-23p19/Ebi3, termed IL-39, a…

The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM Open

Dejun Sun, Miaonan Sun, Wenhe Zhu, Zhiding Wang, Yuefei Li , et al. · 2015

Melittin, which acts as a membrane-disrupting lytic peptide, is not only cytotoxic to tumors, but also vital to normal cells. Melittin had low toxicity when coupled with target peptides. Despite significant research development with the fu…

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