Zhifang Guan
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View article: Evaluation of cerebrospinal fluid treponema pallidum particle agglutination assay titer for neurosyphilis diagnosis among HIV-negative syphilis patients
Evaluation of cerebrospinal fluid treponema pallidum particle agglutination assay titer for neurosyphilis diagnosis among HIV-negative syphilis patients Open
Purpose The study aimed to assess the association between CSF-TPPA titer and the presence of neurosyphilis, and to determine the optimal CSF-TPPA titer cutoff for diagnosing neurosyphilis. Methods We conducted a cross-sectional study at a …
View article: Evaluation of cerebrospinal fluid treponema pallidum particle agglutination assay titer for neurosyphilis diagnosis among HIV-negative syphilis patients
Evaluation of cerebrospinal fluid treponema pallidum particle agglutination assay titer for neurosyphilis diagnosis among HIV-negative syphilis patients Open
Purpose The study aimed to assess the association between CSF-TPPA titer and the presence of neurosyphilis, and to determine the optimal CSF-TPPA titer cutoff for diagnosing neurosyphilis. Methods We conducted a cross-sectional study at a …
View article: Immunohistochemical Analyses of Skin Lesions with Monkeypox Virus A29 and A35 Antibodies: A Novel Insight for Clinical-Histopathological Forms
Immunohistochemical Analyses of Skin Lesions with Monkeypox Virus A29 and A35 Antibodies: A Novel Insight for Clinical-Histopathological Forms Open
The aim of this study was to describe the clinical, histopathological, and immunohistochemical characteristics of monkeypox (MPX) and offer meaningful insights into the clinicopathological characteristics. Eight males who have sex with mal…
View article: Clinical spectrum of late symptomatic neurosyphilis in China: an 11-year retrospective study
Clinical spectrum of late symptomatic neurosyphilis in China: an 11-year retrospective study Open
Objectives This study aimed to describe the clinical features of neurosyphilis in Chinese patients in an attempt to find clinical features that are helpful for the early identification of neurosyphilis. Methods This retrospective study inc…
View article: Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?
Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis? Open
This study was conducted to compare the effectiveness of ceftriaxone with that of aqueous crystalline penicillin G in treating ocular syphilis. We conducted a retrospective study from 2010 to 2021. Syphilis patients were administered eithe…
View article: An observational prospective study based on a large cohort of HIV-negative neurosyphilis patients with particular reference to the Jarisch-Herxheimer reaction
An observational prospective study based on a large cohort of HIV-negative neurosyphilis patients with particular reference to the Jarisch-Herxheimer reaction Open
Purpose The purpose of this study is to outline a complete picture of Jarisch-Herxheimer reaction (JHR) in the central nervous system among HIV-negative neurosyphilis patients. Methods A prospective study cohort of 772 cases with almost al…
View article: Clinical parameter-based prediction model for neurosyphilis risk stratification
Clinical parameter-based prediction model for neurosyphilis risk stratification Open
Accurately predicting neurosyphilis prior to a lumbar puncture (LP) is critical for the prompt management of neurosyphilis. However, a valid and reliable model for this purpose is still lacking. This study aimed to develop a nomogram for t…
View article: Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients
Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients Open
Syphilis is a sexually transmitted disease caused by Treponema pallidum sub. pallidum. T. pallidum can invade many organs, and T. pallidum DNA can be detected in various tissues and fluids. The results reported here demonstrated that T. pa…
View article: Clinical Features and Corrected Factors with Neurosyphilis in HIV/Syphilis Co-Infected Patients Based on Stage of Syphilis
Clinical Features and Corrected Factors with Neurosyphilis in HIV/Syphilis Co-Infected Patients Based on Stage of Syphilis Open
Objective: Neurosyphilis is challenging to diagnose, especially in patients with human immunodeficiency virus (HIV)/syphilis co-infection. The aim of this study was to profile the clinical features of neurosyphilis and evaluate the correla…
View article: A New Specimen for Syphilis Diagnosis: Evidence by High Loads of<i>Treponema pallidum</i>DNA in Saliva
A New Specimen for Syphilis Diagnosis: Evidence by High Loads of<i>Treponema pallidum</i>DNA in Saliva Open
Background DNA from many pathogens can be detected in saliva. However, the presence and quantity of Treponema pallidum DNA in patients with syphilis in saliva is unknown. Methods 234 patients with syphilis with different stages and 30 volu…
View article: P772 Gastric syphilis: a case of gastric syphilis developed into neurosyphilis
P772 Gastric syphilis: a case of gastric syphilis developed into neurosyphilis Open
Background Syphilis caused by the spirochetes Treponema pallidum, which transmitted mainly through sexual contact and blood transmission. The spirochetes spread from the damaged skin to bloodstream, at which point any organ may be affected…
View article: P770 Jarisch-herxheimer reaction in central nervous system among neurosyphilis patients: discontinuation of therapy or not?
P770 Jarisch-herxheimer reaction in central nervous system among neurosyphilis patients: discontinuation of therapy or not? Open
Background Syphilis has returned to china with a vengeance since the 21st century, and the epidemiology of neurosyphilis has largely paralleled that of active syphilis. Prompt therapy with high-dose intravenous benzylpenicillin is critical…
View article: Sensitive detection of <i>Treponema pallidum</i> DNA from the whole blood of patients with syphilis by the nested PCR assay
Sensitive detection of <i>Treponema pallidum</i> DNA from the whole blood of patients with syphilis by the nested PCR assay Open
The aim of this work was to investigate the application of the nested PCR assay for the detection of Treponema pallidum (TP) DNA from the blood of patients with different stages of syphilis. In this study, a nested PCR method targeting the…
View article: Sensitive detection of <i>Treponema pallidum</i> DNA from the whole blood of patients with syphilis by the nested PCR assay
Sensitive detection of <i>Treponema pallidum</i> DNA from the whole blood of patients with syphilis by the nested PCR assay Open
The aim of this work was to investigate the application of the nested PCR assay for the detection of Treponema pallidum (TP) DNA from the blood of patients with different stages of syphilis. In this study, a nested PCR method targeting the…
View article: Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid
Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid Open
CXCL13/CXCR5 mediated the aggregation of B cells, that directed the aberrant humoral immune responses via the formation of EGCs, which suggests a molecular mechanism of neurological damage in neurosyphilis.
View article: Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter? Open
Benzylpenicillin-induced neutropenia was uncommon in our cohort of patients. Continuation of therapy was possible with intensive surveillance for those with mild or moderate neutropenia. For severe neutropenia, it is not essential to aggre…