Zhifang Zhang
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View article: Oncolytic Properties of the Chimeric Poxvirus HOV-2 in Cholangiocarcinoma Models
Oncolytic Properties of the Chimeric Poxvirus HOV-2 in Cholangiocarcinoma Models Open
Introduction: Cholangiocarcinoma (CCA) is a neoplasm of the biliary system and the second-most common primary hepatic malignancy. Neoadjuvant chemotherapy has become mainstay, however five-year survival rates remain poor, prompting the nee…
View article: Oncolytic Virotherapy in Solid Tumors: A Current Review
Oncolytic Virotherapy in Solid Tumors: A Current Review Open
Oncolytic viruses (OVs) are naturally occurring or genetically modified viruses that selectively target cancer cells for infection, replication, and lysis. Specifically, their tumor tropism and promising antitumoral efficacy through direct…
View article: Improving Generalizability and Undetectability for Targeted Adversarial Attacks on Multimodal Pre-trained Models
Improving Generalizability and Undetectability for Targeted Adversarial Attacks on Multimodal Pre-trained Models Open
Multimodal pre-trained models (e.g., ImageBind), which align distinct data modalities into a shared embedding space, have shown remarkable success across downstream tasks. However, their increasing adoption raises serious security concerns…
View article: CF33-hNIS-antiPDL1 enhances immunogenicity and anti-tumor efficacy in an orthotopic syngeneic pancreatic cancer mouse model
CF33-hNIS-antiPDL1 enhances immunogenicity and anti-tumor efficacy in an orthotopic syngeneic pancreatic cancer mouse model Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a tumor-protective immune microenvironment that limits the efficacy of current immunotherapeutic agents, underscoring the need for novel strategies. We previously demonstrated tha…
View article: JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance
JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance Open
Adipose tissue inflammation contributes to obesity-induced insulin resistance. However, increasing evidence shows that high BMI (obesity) is not an accurate predictor of poor metabolic health in individuals. The molecular mechanisms regula…
View article: A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils
A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils Open
Introduction Monoosteophils, derived from LL-37-treated monocytes, are a novel type of calcifying/bone forming cells. We have shown that monoosteophils can form bone-like nodules in vitro and accelerate bone repair in a drilled femur defec…
View article: The crystal structure of 2-(2-hydroxy-4-n-octyloxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, C<sub>33</sub>H<sub>39</sub>N<sub>3</sub>O<sub>2</sub>
The crystal structure of 2-(2-hydroxy-4-n-octyloxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, C<sub>33</sub>H<sub>39</sub>N<sub>3</sub>O<sub>2</sub> Open
C 33 H 39 N 3 O 2 , monoclinic, P 2 1 / n (no. 14), a = 15.6706(4) Å, b = 4.02399(11) Å, c = 43.4356(11) Å, β = 99.098(3)°, V = 2,704.53(13) Å 3 , Z = 4, R gt ( F ) = 0.0423, w R ref ( F 2 ) = 0.1224, T = 100 K.
View article: Developmental trajectories of suicide risk in college students: a three-year Latent Growth Mixed Model study
Developmental trajectories of suicide risk in college students: a three-year Latent Growth Mixed Model study Open
Background This study aimed to explore the developmental trajectories of suicide risk among college students and examine the influence of demographic, psychological, and social factors on these trajectories. Methods A three-year follow-up …
View article: A tailored nanocarrier DMON and CpGs synergistically drive the formulation of a highly immunogenic and long-acting vaccine against echinococcosis
A tailored nanocarrier DMON and CpGs synergistically drive the formulation of a highly immunogenic and long-acting vaccine against echinococcosis Open
Hydatid disease (echinococcosis) is a zoonotic parasitic disease that seriously endangers human health and livestock production. To develop a safer, more effective vaccine with an exceptionally long-lasting immune response, we employed an …
View article: Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses
Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses Open
Plants live under various biotic and abiotic stress conditions, and to cope with the adversity and severity of these conditions, they have developed well-established resistance mechanisms. These mechanisms begin with the perception of stim…
View article: IMPAIRED RESTING-STATE ANTERIOR PREFRONTAL FUNCTIONAL CONNECTIVITY ASSOCIATED WITH PROSPECTIVE MEMORY DEFICITS IN SCHIZOPHRENIA
IMPAIRED RESTING-STATE ANTERIOR PREFRONTAL FUNCTIONAL CONNECTIVITY ASSOCIATED WITH PROSPECTIVE MEMORY DEFICITS IN SCHIZOPHRENIA Open
Background Prospective memory (PM) deficit is one of the most common cognitive impairments of patients with schizophrenia spectrum disorders (SSDs). PM deficits have been associated with social functioning impairment, poor adherence to dru…
View article: A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model
A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model Open
Our data demonstrated that the ferritin-CpG hybrid is a promising combination adjuvant to upgrade the traditional Quil-A and this combination adjuvant-based nanovaccine presents good potential as an alternative to the commercial one for pr…
View article: Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder
Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder Open
The nucleus accumbens (NAc) plays a crucial role in the pathophysiology of major depressive disorder (MDD), and abnormal resting-state functional connectivity (rsFC) of NAc subregions has been found in MDD. However, it is unclear whether t…
View article: Bibliometric and visual analysis of radiomics for evaluating lymph node status in oncology
Bibliometric and visual analysis of radiomics for evaluating lymph node status in oncology Open
Background Radiomics, which involves the conversion of digital images into high-dimensional data, has been used in oncological studies since 2012. We analyzed the publications that had been conducted on this subject using bibliometric and …
View article: Contribution of resting-state functional connectivity of the subgenual anterior cingulate to prediction of antidepressant efficacy in patients with major depressive disorder
Contribution of resting-state functional connectivity of the subgenual anterior cingulate to prediction of antidepressant efficacy in patients with major depressive disorder Open
This study investigated how resting-state functional connectivity (rsFC) of the subgenual anterior cingulate cortex (sgACC) predicts antidepressant response in patients with major depressive disorder (MDD). Eighty-seven medication-free MDD…
View article: Figure S1 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model
Figure S1 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model Open
PET imaging at different time points
View article: Figure S2 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model
Figure S2 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model Open
HMGB1 staining on tumor sections
View article: Figure S2 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model
Figure S2 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model Open
HMGB1 staining on tumor sections
View article: Figure S1 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model
Figure S1 from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model Open
PET imaging at different time points
View article: Data from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model
Data from An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model Open
Oncolytic viruses (OVs) are live viruses that can selectively replicate in cancer cells. We have engineered an OV (CF33) to make it cancer-selective through the deletion of its J2R (thymidine kinase) gene. Additionally, this virus has been…
View article: Tuning Vision-Language Models with Candidate Labels by Prompt Alignment
Tuning Vision-Language Models with Candidate Labels by Prompt Alignment Open
Vision-language models (VLMs) can learn high-quality representations from a large-scale training dataset of image-text pairs. Prompt learning is a popular approach to fine-tuning VLM to adapt them to downstream tasks. Despite the satisfyin…
View article: Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study
Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study Open
Background Theoretical and empirical evidence indicates the critical role of the default mode network (DMN) in the pathophysiology of the bipolar disorder (BD). This study aims to identify the specific brain regions of the DMN that is impa…
View article: Altered effective connectivity among face-processing systems in major depressive disorder
Altered effective connectivity among face-processing systems in major depressive disorder Open
Background: Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. Ho…
View article: Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer
Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer Open
A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes. We hypothesized that in gastric cancer (GC), macrophages in a polarized immunosup…
View article: Further clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements
Further clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements Open
The aim of this study is to compare ecologically-valid measure (the Cambridge Prospective Memory Test, CAMPROMPT) and laboratory measure (eye-tracking paradigm) in assessing prospective memory (PM) in individuals with schizophrenia spectru…
View article: A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity
A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity Open
Therefore, fenobodies can be well self-assembled in silkworm baculovirus expression system, and ferritin self-assembly technology can effectively improve nanobody neutralization activity.
View article: Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder
Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder Open
Background Bipolar disorder (BD) is a complex mental illness characterized by different mood states, including depression, mania/hypomania, and euthymia. This study aimed to comprehensively evaluate dynamic changes in intrinsic brain activ…
View article: Atrial Septal Defect Detection in Children Based on Ultrasound Video Using Multiple Instances Learning
Atrial Septal Defect Detection in Children Based on Ultrasound Video Using Multiple Instances Learning Open
View article: Targeting a cardiac abundant and fibroblasts-specific piRNA (CFRPi) to attenuate and reverse cardiac fibrosis in pressure-overloaded heart failure
Targeting a cardiac abundant and fibroblasts-specific piRNA (CFRPi) to attenuate and reverse cardiac fibrosis in pressure-overloaded heart failure Open
View article: Corrigendum: Comparison of cardiac function between single left ventricle and tricuspid atresia: assessment using echocardiography combined with computational fluid dynamics
Corrigendum: Comparison of cardiac function between single left ventricle and tricuspid atresia: assessment using echocardiography combined with computational fluid dynamics Open
[This corrects the article DOI: 10.3389/fped.2023.1159342.].