Zhigang Liu
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View article: Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trial
Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trial Open
Introduction With the global ageing population accelerating, the prevalence of Alzheimer’s disease (AD) continues to rise annually. However, the underlying mechanisms of AD remain unclear, and effective treatments are still lacking. Apolip…
View article: Enhancing the Protection Performance of Flared End Terminals for Roadside Guardrails: A Recycling-Based Approach
Enhancing the Protection Performance of Flared End Terminals for Roadside Guardrails: A Recycling-Based Approach Open
China is steering its industries toward green, low-carbon, and circular development by promoting the circular economy and enhancing comprehensive resource utilization. This study investigates dismantled two-wave beam guardrails and propose…
View article: Thermal-Assisted Aerobic Composting: A Sustainable Approach to Sludge Dewatering and Process Optimization
Thermal-Assisted Aerobic Composting: A Sustainable Approach to Sludge Dewatering and Process Optimization Open
View article: Overexpression of GhCAD6 in Upland Cotton (Gossypium hirsutum L.) Enhances Fiber Quality and Increases Lignin Content in Fibers
Overexpression of GhCAD6 in Upland Cotton (Gossypium hirsutum L.) Enhances Fiber Quality and Increases Lignin Content in Fibers Open
Cotton is a vital economic crop, and cotton fiber serves as the primary raw material for the textile industry. Lignin in cotton fiber is closely associated with fiber quality. Lignin is synthesized through the phenylpropanoid metabolic pat…
View article: A Synbiotic of Bifidobacterium animalis subsp. lactis BB-12 and 2′-FL Alleviate Infant Diarrhea and Anxiety-like Behaviors via Gut Microbiota Modulation in an EPEC O127 Infection Model
A Synbiotic of Bifidobacterium animalis subsp. lactis BB-12 and 2′-FL Alleviate Infant Diarrhea and Anxiety-like Behaviors via Gut Microbiota Modulation in an EPEC O127 Infection Model Open
Background/Objectives: Infant diarrhea is a major global cause of morbidity and mortality. While Bifidobacterium is linked to diarrhea, its preventive effects, underlying mechanisms, and potential synergistic benefits with prebiotics remai…
View article: From support to recovery: the evolving role of LVAD in reversing heart failure
From support to recovery: the evolving role of LVAD in reversing heart failure Open
In recent years, the use of Left Ventricular Assist Devices (LVAD) in the treatment of heart failure has been increasingly widespread. Not only do they provide circulatory support for patients, but the reverse biological changes in myocard…
View article: Characterization and genomics of phage Henu2_3 against K1 Klebsiella pneumoniae and its efficacy in animal models
Characterization and genomics of phage Henu2_3 against K1 Klebsiella pneumoniae and its efficacy in animal models Open
The emergence and spread of multidrug-resistant and super-resistant bacterial strains have positioned phage therapy as a highly promising approach for future infection treatments. Klebsiella pneumoniae , a leading cause of clinical infecti…
View article: An automatic algorithm for surface wave dispersion curve picking based on Hessian matrix attributes
An automatic algorithm for surface wave dispersion curve picking based on Hessian matrix attributes Open
View article: Synbiotics of <i>Lactobacillus suilingensis</i> and inulin alleviates cognitive impairment via regulating gut microbiota indole‐3‐lactic acid metabolism in female AD mice
Synbiotics of <i>Lactobacillus suilingensis</i> and inulin alleviates cognitive impairment via regulating gut microbiota indole‐3‐lactic acid metabolism in female AD mice Open
INTRODUCTION Recent studies have found that gut microbial tryptophan metabolism is altered in Alzheimer's disease (AD) patients. However, the functional consequences of these changes and their therapeutic potential remain unclear. METHODS …
View article: P-805 The follicular fluid derived exsomal miR-203-3p facilitate the the differentiation of oocytes from human induced pluripotent stem cells through PI3K / Akt molecular axis
P-805 The follicular fluid derived exsomal miR-203-3p facilitate the the differentiation of oocytes from human induced pluripotent stem cells through PI3K / Akt molecular axis Open
Study question Can the follicular fluid derived exosomes facilitate the induction differentiation of oocytes from induced pluripotent stem cells (iPSCs) in vitro? Summary answer The follicular fluid derived exosomes promoted the induced di…
View article: Single atom-substituted gold nanoclusters for alleviating neural injury induced by deep hypothermic circulatory arrest
Single atom-substituted gold nanoclusters for alleviating neural injury induced by deep hypothermic circulatory arrest Open
The newly developed AuNCs alleviated the neural injury induced by DHCA through anti-inflammation, antioxidant, and anti-apoptosis activity. These findings offer a novel avenue for achieving perioperative brain protection in clinical DHCA a…
View article: n-3 Polyunsaturated Fatty Acids Substitution for Saturated Fatty Acids in Diet Ameliorates Age-Related Cognitive Decline via ABCA1/ApoE-Mediated Lipid Efflux
n-3 Polyunsaturated Fatty Acids Substitution for Saturated Fatty Acids in Diet Ameliorates Age-Related Cognitive Decline via ABCA1/ApoE-Mediated Lipid Efflux Open
View article: Physical Fatigue of Emergency Workers After Rush Entry Into the Low-Oxygen Environment at High Altitude
Physical Fatigue of Emergency Workers After Rush Entry Into the Low-Oxygen Environment at High Altitude Open
Objective This study aimed to characterize the epidemiological and physiological features of fatigue in high-altitude hypoxic environments, providing evidence for emergency management. Methods An observational study examined emergency resc…
View article: Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating Mast Cell Hyperactivation
Lactobacillus plantarum and Galacto-Oligosaccharides Synbiotic Relieve Irritable Bowel Syndrome by Reshaping Gut Microbiota and Attenuating Mast Cell Hyperactivation Open
Background: Irritable bowel syndrome (IBS) significantly impairs the lifestyle and quality of life of the global population. However, the underlying pathophysiological mechanisms remain largely elusive. While conventional pharmacological a…
View article: Integrated gut microbiome and serum metabolomics analysis to reveal seawater adaptation strategy in Chinese sturgeon
Integrated gut microbiome and serum metabolomics analysis to reveal seawater adaptation strategy in Chinese sturgeon Open
View article: Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice
Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice Open
Prenatal IPA is transferred to the fetus and promotes gut development, conferring long-term protection against colitis in MIA offspring. These findings underscore the enduring impact of maternal interventions on offspring intestinal health.
View article: Impact of fructooligosaccharides on gut microbiota and microbial metabolites in gestational diabetes mellitus: An in vitro fermentation model study
Impact of fructooligosaccharides on gut microbiota and microbial metabolites in gestational diabetes mellitus: An in vitro fermentation model study Open
Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder linked to gut microbiota dysbiosis. This study investigates the effects of fructooligosaccharides (FOS) on gut microbiota, microbial metabolites, and functional pathways…
View article: Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management
Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management Open
Gallstone disease (GSD) and metabolic syndrome (MetS) are increasingly prevalent conditions with significant global health implications. Recent evidence highlights a strong epidemiological association between these disorders, driven by sha…
View article: Optimizing drying of municipal dewatered sludge using heat-assisted microorganisms and pig manure addition: A process and economic analysis
Optimizing drying of municipal dewatered sludge using heat-assisted microorganisms and pig manure addition: A process and economic analysis Open
View article: Chromosome-level genome assembly of Jaguar guapote (Parachromis manguensis) by massive parallel sequencing
Chromosome-level genome assembly of Jaguar guapote (Parachromis manguensis) by massive parallel sequencing Open
View article: Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a <i>B. pseudolongum</i>‐propionic acid‐FFAR3 axis
Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a <i>B. pseudolongum</i>‐propionic acid‐FFAR3 axis Open
Time‐restricted feeding (TRF) holds promise for alleviating cognitive decline in aging, albeit the precise mechanism via the gut‐brain axis remains elusive. In a clinical trial, we observed, for the first time, that a 4‐month TRF ameliorat…
View article: Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats Open
View article: The modified heart team protocol facilitated the revascularization decision-making quality in complex coronary artery disease
The modified heart team protocol facilitated the revascularization decision-making quality in complex coronary artery disease Open
OBJECTIVES A lack of standardization in heart team implementation potentially leads to suboptimal decision-making quality, and we previously established a modified heart team protocol to improve the decision-making quality. The present tri…
View article: Expert consensus on the use of oropharyngeal probiotic Bactoblis in respiratory tract infection and otitis media: available clinical evidence and recommendations for future research
Expert consensus on the use of oropharyngeal probiotic Bactoblis in respiratory tract infection and otitis media: available clinical evidence and recommendations for future research Open
View article: Venetoclax in combination with chidamide and azacitidine for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia with the MLL-AF4 gene: a case report and literature review
Venetoclax in combination with chidamide and azacitidine for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia with the MLL-AF4 gene: a case report and literature review Open
B-cell acute lymphoblastic leukemia (B-ALL) with the MLL-AF4 fusion gene has a poor prognosis, and the mortality rate exceeds 90%, particularly in cases of extramedullary relapse (EMR). Herein, we present a case of a 46-year-old male patie…
View article: Preparation of Cobalt-Doped Spent Coffee Grounds Magnetic Composite Microspheres and Highly Efficient Degradation of Tetracycline by Persulfate
Preparation of Cobalt-Doped Spent Coffee Grounds Magnetic Composite Microspheres and Highly Efficient Degradation of Tetracycline by Persulfate Open
View article: Overexpression of Ghcad6 in Upland Cotton Enhances Fiber Quality and Increases Lignin Content in Fibers
Overexpression of Ghcad6 in Upland Cotton Enhances Fiber Quality and Increases Lignin Content in Fibers Open
View article: Risk classification for non-cancer death in middle-aged cancer patients
Risk classification for non-cancer death in middle-aged cancer patients Open
The risk of non-cancer death was elevated in middle-aged cancer patients and varied for different cancer types. A new risk classification system was developed to estimate the risk of non-cancer deaths in different cancers, and the 24 cance…
View article: Effect of the gut core microbiota Cetobacterium on the growth, physiology, and nutritional metabolism of Nile tilapia (Oreochromis niloticus)
Effect of the gut core microbiota Cetobacterium on the growth, physiology, and nutritional metabolism of Nile tilapia (Oreochromis niloticus) Open
As a gut core microbiota in tilapia, Cetobacterium likely plays an essential nutritional role in the gut. We performed a feeding experiment to identify its function in the growth, physiology, and nutritional metabolism in Nile tilapia (Ore…
View article: Arbuscular mycorrhizal fungi enhance drought resistance and alter microbial communities in maize rhizosphere soil
Arbuscular mycorrhizal fungi enhance drought resistance and alter microbial communities in maize rhizosphere soil Open