Zheng Xiang
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View article: Dumbbell ganglioneuroma of the lumbar spine: a case report and literature review
Dumbbell ganglioneuroma of the lumbar spine: a case report and literature review Open
Background Ganglioneuroma (GN) of the lumbar spine is rare, typically occurring in children and young adults. Its diagnosis in middle-aged patients can be challenging. This paper reports a case of a dumbbell-shaped lumbar GN in a middle-ag…
View article: Controllable Charge Storability in InP/ZnSe Core/Shell Quantum Dots toward Bioinspired Optical Synaptic Application
Controllable Charge Storability in InP/ZnSe Core/Shell Quantum Dots toward Bioinspired Optical Synaptic Application Open
Optoelectronic materials with proper charge storage play a pivotal role in the development of artificial neuromorphic devices aiming to mimic the visual, sensory, and memory functions of the human nervous system. This study presents the co…
View article: Genetic diversity and population structures of Plasmodium falciparum parasites imported to China from Central and West Africa determined using a SNP barcode
Genetic diversity and population structures of Plasmodium falciparum parasites imported to China from Central and West Africa determined using a SNP barcode Open
The present study validated the potential of the 24-SNP HRM barcode in examining diversity and variations in imported P. falciparum populations. Our studies confirmed that this barcode is insufficient for distinguishing isolates from Centr…
View article: Targeting lactate metabolism to restore immune homeostasis: a precision therapeutic paradigm for rheumatoid arthritis
Targeting lactate metabolism to restore immune homeostasis: a precision therapeutic paradigm for rheumatoid arthritis Open
The accumulation of lactate in synovial microenvironment of rheumatoid arthritis (RA) patients is closely correlated with disease activity, with elevated lactate levels serving as both biomarkers and pathogenic mediators in RA progression.…
View article: Occult Hypercalcemia Unmasked: Insights From Remitting Seronegative Symmetrical Synovitis With Pitting Edema (RS3PE) Syndrome Associated With a Gastrointestinal Lymphoma
Occult Hypercalcemia Unmasked: Insights From Remitting Seronegative Symmetrical Synovitis With Pitting Edema (RS3PE) Syndrome Associated With a Gastrointestinal Lymphoma Open
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis that may present as a paraneoplastic syndrome. We report a case of a 51-year-old woman who initially responded to high-dose steroids f…
View article: Acetyl-CoA synthetase mutations affect the susceptibility of <i>Plasmodium falciparum</i> to antimalarial drugs
Acetyl-CoA synthetase mutations affect the susceptibility of <i>Plasmodium falciparum</i> to antimalarial drugs Open
Plasmodium falciparum acetyl-CoA synthetase (PfAcAS) is an important source of acetyl-CoA. We detected mutations S868G and V950I in PfAcAS by whole-genome sequencing analysis in certain recrudescent parasites after treatment with artesunat…
View article: Prognostic Value of Pre‐Treatment Diffusion Kurtosis Imaging for Progression‐Free Survival Prediction in Advanced Nasopharyngeal Carcinoma
Prognostic Value of Pre‐Treatment Diffusion Kurtosis Imaging for Progression‐Free Survival Prediction in Advanced Nasopharyngeal Carcinoma Open
Purpose This study aimed to evaluate the value of diffusion kurtosis imaging (DKI) for prognostic value for long‐term PFS in nasopharyngeal carcinoma (NPC). Methods A cohort of 295 NPC patients underwent pretreatment 3.0T MRI with DKI to d…
View article: The Global Immune-Nutrition Inflammation Index for Predicting Coronary Slow Flow Phenomenon in Patients with Angina and No Obstructive Coronary Arteries
The Global Immune-Nutrition Inflammation Index for Predicting Coronary Slow Flow Phenomenon in Patients with Angina and No Obstructive Coronary Arteries Open
Elevated GINI is a reliable predictor of CSFP in patients with ANOCA. Moreover, GINI had a superior predictive value compared to the indicators alone. As a newly developed inflammatory indicator, GINI can be used for further risk stratific…
View article: Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs
Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs Open
Plasmodium falciparum acetyl-CoA synthetase (PfACAS) protein is an important source of acetyl-CoA. We detected the mutations S868G and V949I in PfACAS by whole-genome sequencing analysis in some recrudescent parasites after antimalarial tr…
View article: Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs<i>in vitro</i>in<i>Plasmodium falciparum</i>
Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs<i>in vitro</i>in<i>Plasmodium falciparum</i> Open
Plasmodium falciparum acetyl-CoA synthetase (PfACAS) protein is an important source of acetyl-CoA. We detected the mutations S868G and V949I in PfACAS by whole-genome sequencing analysis in some recrudescent parasites after antimalarial tr…
View article: Absence of association between Pfnfs1 mutation and in vitro susceptibility to lumefantrine in Plasmodium falciparum
Absence of association between Pfnfs1 mutation and in vitro susceptibility to lumefantrine in Plasmodium falciparum Open
View article: An imported malaria case with repeated episodes of neurological syndromes resulting from different Plasmodium species
An imported malaria case with repeated episodes of neurological syndromes resulting from different Plasmodium species Open
View article: Seroprevalence and transmission of severe fever with thrombocytopenia syndrome virus in a coastal endemic area in Southeastern China
Seroprevalence and transmission of severe fever with thrombocytopenia syndrome virus in a coastal endemic area in Southeastern China Open
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerged tick-borne viral zoonosis and widely prevalent in China, Japan and South Korea. Most reported SFTS cases have been identified in mountainous and hilly areas, with a few …
View article: Population pharmacokinetic modeling and simulation for nirmatrelvir exposure assessment in Chinese older patients with COVID-19 infection
Population pharmacokinetic modeling and simulation for nirmatrelvir exposure assessment in Chinese older patients with COVID-19 infection Open
Nirmatrelvir is an effective component of Paxlovid, the first oral antiviral drug granted emergency use authorization by the FDA. Nirmatrelvir is prescribed extensively in older adult patients to treat the coronavirus disease 2019 (COVID-1…
View article: Age- and Gender-Specific Diagnostic Value of the Albumin-to-Creatinine Ratio for the Early Screening of Chronic Kidney Disease Among Middle-Aged and Elderly Males in Southeast China
Age- and Gender-Specific Diagnostic Value of the Albumin-to-Creatinine Ratio for the Early Screening of Chronic Kidney Disease Among Middle-Aged and Elderly Males in Southeast China Open
We proposed using the urinary ACR for the screening of physically examined patients, especially among the elderly males. This approach would assist in the early diagnosis and treatment of renal damage.
View article: Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults
Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults Open
Ageing is often accompanied with a decline in immune system function, resulting in immune ageing. Numerous studies have focussed on the changes in different lymphocyte subsets in diseases and immunosenescence. The change in immune phenotyp…
View article: A simple alkali lysis method for Plasmodium falciparum DNA extraction from filter paper blood samples
A simple alkali lysis method for Plasmodium falciparum DNA extraction from filter paper blood samples Open
View article: Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study Open
BACKGROUND Delayed graft function (DGF) caused by ischemia-reperfusion injury is a common pathophysiological process that should be monitored by specific biomarkers in addition to serum creatinine. Thus, this single-center retrospective st…
View article: Genetic diversity of Plasmodium vivax populations from the China–Myanmar border identified by genotyping merozoite surface protein markers
Genetic diversity of Plasmodium vivax populations from the China–Myanmar border identified by genotyping merozoite surface protein markers Open
View article: PvMSP-3α and PvMSP-3β genotyping reveals higher genetic diversity in Plasmodium vivax parasites from migrant workers than residents at the China-Myanmar border
PvMSP-3α and PvMSP-3β genotyping reveals higher genetic diversity in Plasmodium vivax parasites from migrant workers than residents at the China-Myanmar border Open
Both PvMSP-3 paralogs were subjected to diversifying selection in each sample population. Clustering of alleles supports ephemeral endemic differentiation of alleles, but the broader phylogeny suggests that alleles transit the globe, perha…
View article: Application of a low-cost, specific, and sensitive loop-mediated isothermal amplification (LAMP) assay to detect Plasmodium falciparum imported from Africa
Application of a low-cost, specific, and sensitive loop-mediated isothermal amplification (LAMP) assay to detect Plasmodium falciparum imported from Africa Open
View article: COVID-19 vaccination influences subtypes of γδ-T cells during pregnancy
COVID-19 vaccination influences subtypes of γδ-T cells during pregnancy Open
Up to now, there has been insufficient clinical data to support the safety and effects of vaccination on pregnancy post COVID-19 vaccination. The γδ-T cells are considered an important component in the immune system to fight against viral …
View article: Phenotypic Changes of Peripheral γδ T Cell and Its Subsets in Patients With Coronary Artery Disease
Phenotypic Changes of Peripheral γδ T Cell and Its Subsets in Patients With Coronary Artery Disease Open
Coronary atherosclerotic heart disease (CAD) is a chronic inflammatory cardiovascular disease with high morbidity and mortality. Growing data indicate that many immune cells are involved in the development of atherosclerosis. However, the …
View article: CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment
CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment Open
Although γδ-T cell-based tumor immunotherapy using phosphoantigens to boost γδ-T cell immunity has shown success in some cancer patients, the clinical application is limited due to the rapid exhaustion of Vγ9Vδ2-T cells caused by repetitiv…
View article: The genetic evolution and codon usage pattern of severe fever with thrombocytopenia syndrome virus
The genetic evolution and codon usage pattern of severe fever with thrombocytopenia syndrome virus Open
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging zoonotic infectious disease caused by the SFTS virus (SFTSV), which has been continuously circulating in Eastern Asia in recent years. Although the evolution of SFTSV h…
View article: Resistance of SARS-CoV-2 Omicron variant to convalescent and CoronaVac vaccine plasma
Resistance of SARS-CoV-2 Omicron variant to convalescent and CoronaVac vaccine plasma Open
View article: Temporal and gene reassortment analysis of influenza C virus outbreaks in Hong Kong, SAR, China.
Temporal and gene reassortment analysis of influenza C virus outbreaks in Hong Kong, SAR, China. Open
From 2014 to week 07/2020 the Centre for Health Protection in Hong Kong conducted screening for influenza C virus (ICV). A retrospective analysis of ICV detections to week 26/2019 revealed persistent low-level circulation with outbreaks oc…
View article: A ten-year assessment of the epidemiological features and fatal risk factors of hospitalised severe fever with thrombocytopenia syndrome in Eastern China
A ten-year assessment of the epidemiological features and fatal risk factors of hospitalised severe fever with thrombocytopenia syndrome in Eastern China Open
Severe fever with thrombocytopenia syndrome (SFTS) virus has caused a large number of human infections since discovered in 2009. This study elucidated epidemiological features and fatal risk factors of SFTS cases accumulated up to ten year…
View article: Molecular Surveillance and Ex Vivo Drug Susceptibilities of Plasmodium vivax Isolates From the China–Myanmar Border
Molecular Surveillance and Ex Vivo Drug Susceptibilities of Plasmodium vivax Isolates From the China–Myanmar Border Open
Drug resistance in Plasmodium vivax may pose a challenge to malaria elimination. Previous studies have found that P. vivax has a decreased sensitivity to antimalarial drugs in some areas of the Greater Mekong Sub-region. This study aims to…
View article: Unraveling the Complexity of Imported Malaria Infections by Amplicon Deep Sequencing
Unraveling the Complexity of Imported Malaria Infections by Amplicon Deep Sequencing Open
Imported malaria and recurrent infections are becoming an emerging issue in many malaria non-endemic countries. This study aimed to determine the molecular patterns of the imported malaria infections and recurrence. Blood samples were coll…