Lin Zhan
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View article: DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway
DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway Open
Background Angiogenesis is an important mechanism in stroke therapy. Circular RNA-DICAR is known to protect against diabetes-induced cardiomyocyte pyroptosis. In this study, we examined the effect of DICAR on angiogenesis as well as the th…
View article: Summary of evidence on preventing unplanned extubation of adult gastric and nasointestinal tubes
Summary of evidence on preventing unplanned extubation of adult gastric and nasointestinal tubes Open
Objective The aim of this study is to extract and summarize the best evidence for the prevention of unplanned extubation of adult gastric tubes and nasointestinal tubes through evidence-based research, in order to guide clinical practice. …
View article: Ternary Prussian blue nanozymes with synergistic multimetallic catalysis enable ultrasensitive lateral flow immunoassay for respiratory syncytial virus diagnosis
Ternary Prussian blue nanozymes with synergistic multimetallic catalysis enable ultrasensitive lateral flow immunoassay for respiratory syncytial virus diagnosis Open
View article: Speculative Decoding Reimagined for Multimodal Large Language Models
Speculative Decoding Reimagined for Multimodal Large Language Models Open
This paper introduces Multimodal Speculative Decoding (MSD) to accelerate Multimodal Large Language Models (MLLMs) inference. Speculative decoding has been shown to accelerate Large Language Models (LLMs) without sacrificing accuracy. Howe…
View article: High Diversity and Prevalence of Rickettsial Agents in Rhipicephalus microplus Ticks from Livestock in Karst Landscapes of Southwest China
High Diversity and Prevalence of Rickettsial Agents in Rhipicephalus microplus Ticks from Livestock in Karst Landscapes of Southwest China Open
Ticks and tick-borne pathogens pose a significant threat to human and animal health, yet the diversity and prevalence of tick-borne microorganisms in karst regions remains inadequately explored. In October 2023, a total of 274 Rhipicephalu…
View article: LightMotion: A Light and Tuning-free Method for Simulating Camera Motion in Video Generation
LightMotion: A Light and Tuning-free Method for Simulating Camera Motion in Video Generation Open
Existing camera motion-controlled video generation methods face computational bottlenecks in fine-tuning and inference. This paper proposes LightMotion, a light and tuning-free method for simulating camera motion in video generation. Opera…
View article: Spatiotemporal Recurrent Graph Convolution with a Capsule Network for Traffic Demand Prediction
Spatiotemporal Recurrent Graph Convolution with a Capsule Network for Traffic Demand Prediction Open
View article: Second Language (Arabic) Acquisition of LLMs via Progressive Vocabulary Expansion
Second Language (Arabic) Acquisition of LLMs via Progressive Vocabulary Expansion Open
View article: Second Language (Arabic) Acquisition of LLMs via Progressive Vocabulary Expansion
Second Language (Arabic) Acquisition of LLMs via Progressive Vocabulary Expansion Open
This paper addresses the critical need for democratizing large language models (LLM) in the Arab world, a region that has seen slower progress in developing models comparable to state-of-the-art offerings like GPT-4 or ChatGPT 3.5, due to …
View article: Preventive and Therapeutic Efficacy of Thalidomide in Paclitaxel-Induced Peripheral
Preventive and Therapeutic Efficacy of Thalidomide in Paclitaxel-Induced Peripheral Open
Purpose: The main adverse effects of paclitaxel chemotherapy are arthralgia, myalgia, and neuropathic pain. The objective of this research was to assess the potential preventive benefits, continuous management strategies, and the likelihoo…
View article: Monoclonal Antibodies for Rift Valley Fever Virus Nucleocapsid: Application in IgG/IgM ELISA for Sero-Diagnosis
Monoclonal Antibodies for Rift Valley Fever Virus Nucleocapsid: Application in IgG/IgM ELISA for Sero-Diagnosis Open
Introduction: Rift Valley fever virus (RVFV) belonging to the Phenuiviridae family is responsible for a zoonotic disease called Rift Valley fever (RVF). Currently, RVFV has spread from Africa to Asia, and due to its ability to cause high m…
View article: Genomics evolution of Jingmen viruses associated with ticks and vertebrates
Genomics evolution of Jingmen viruses associated with ticks and vertebrates Open
Jingmen virus (JMV) associated with ticks and vertebrates have been found to be related to human disease. We obtained the genome of a Jingmen tick virus (JMTV) strain from Rhipicephalus microplus in Guizhou province and compared the genome…
View article: The effects of tislelizumab treatment on the <scp>health‐related</scp> quality of life of patients with advanced non‐small cell lung cancer
The effects of tislelizumab treatment on the <span>health‐related</span> quality of life of patients with advanced non‐small cell lung cancer Open
This study examined the health‐related quality of life (HRQoL) of patients with advanced non‐small cell lung cancer (NSCLC) receiving tislelizumab versus docetaxel in the open‐label, multicenter, Phase 3 trial called RATIONALE‐303 (NCT0335…
View article: CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes
CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes Open
View article: Genomics Evolution of Jingmen Viruses Associated with Ticks and Vertebrates
Genomics Evolution of Jingmen Viruses Associated with Ticks and Vertebrates Open
View article: Effect of FOXP2 transcription factor on immune infiltration of thyroid cancer and its potential clinical value
Effect of FOXP2 transcription factor on immune infiltration of thyroid cancer and its potential clinical value Open
Background The clinical outcomes are not always favorable in certain thyroid cancer patients. The effect of Forkhead-box family on immune cells infiltration and tumor microenvironment in thyroid cancer was explored. The role of FOXP2 in tu…
View article: Development of monoclonal antibody based IgG and IgM ELISA for diagnosis of severe fever with thrombocytopenia syndrome virus infection
Development of monoclonal antibody based IgG and IgM ELISA for diagnosis of severe fever with thrombocytopenia syndrome virus infection Open
View article: Development of Monoclonal Antibody Based IgG and IgM ELISA for Diagnosis of Severe Fever with Thrombocytopenia Syndrome Virus Infection
Development of Monoclonal Antibody Based IgG and IgM ELISA for Diagnosis of Severe Fever with Thrombocytopenia Syndrome Virus Infection Open
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly emerged virus that possesses a great threat to human health because of the high fatality rate. Method: To develop sensitive and specific sero-diagnosis system…
View article: Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications
Curcumin and Its Analogs as Potential Epigenetic Modulators: Prevention of Diabetes and Its Complications Open
Background: The pathobiology of diabetes and associated complications has been widely researched in various countries, but effective prevention and treatment methods are still insufficient. Diabetes is a metabolic disorder of…
View article: In Silico Network Analysis of Ingredients of Cornus officinalis in Osteoporosis
In Silico Network Analysis of Ingredients of Cornus officinalis in Osteoporosis Open
BACKGROUND Cornus officinalis (CO), also known as 'Shanzhuyu', is one of the most common traditional Chinese herbs used against osteoporosis. Although previous studies have found that CO has beneficial effects in alleviating osteoporosis, …
View article: A prospective observational study of patient-reported functioning and quality of life in advanced and metastatic breast cancer utilizing a novel mobile application
A prospective observational study of patient-reported functioning and quality of life in advanced and metastatic breast cancer utilizing a novel mobile application Open
Purpose To assess and describe patient-reported outcomes (PROs) in women with locally advanced/unresectable or metastatic breast cancer (aBC/mBC) with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR + /HER2 …
View article: Detection of Novel Spotted Fever Group Rickettsiae (Rickettsiales: Rickettsiaceae) in Ticks (Acari: Ixodidae) in Southwestern China
Detection of Novel Spotted Fever Group Rickettsiae (Rickettsiales: Rickettsiaceae) in Ticks (Acari: Ixodidae) in Southwestern China Open
Spotted fever group rickettsiae, mainly maintained and transmitted by ticks, are important etiological agents of (re)emerging zoonotic diseases worldwide. It is of great significance to investigate spotted fever group rickettsiae in ticks …
View article: High <i>SEC61G</i> expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas
High <i>SEC61G</i> expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas Open
Background: Overexpression of the membrane protein SEC61 translocon gamma subunit (SEC61G) has been observed in a variety of cancers; however, its role in head and neck squamous cell carcinomas (HNSCC) is unknown. This study aimed t…
View article: Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang
Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang Open
Background There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should not completely fol…
View article: Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer：a study from Guangxi Zhuang
Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer：a study from Guangxi Zhuang Open
Background: There are obviously ethnic differences between the UGT1A1 gene polymorphisms.Due to the difference of genetic background and environment,the treatment with colorectal cancer patients of Guangxi Zhuang should not completely foll…
View article: Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer：a study from Guangxi Zhuang
Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer：a study from Guangxi Zhuang Open
Background: UGTlA1 gene polymorphism has different distribution in different ethnicities, geographical regions and ethnic groups, which may lead to different toxicity and efficacy of irinotecan. The study aimed to explore the correlation o…
View article: MicroRNA-145 suppresses epithelial to mesenchymal transition in pancreatic cancer cells by inhibiting TGF-β signaling pathway
MicroRNA-145 suppresses epithelial to mesenchymal transition in pancreatic cancer cells by inhibiting TGF-β signaling pathway Open
TGF-β signaling plays a critical role in tumor progression and many approaches have been made to inhibit its functions. MicroRNA is one of the approaches that inhibit TGF-β signaling and can be used as a promising treatment for cancer. Thi…