Zhihong Yang
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View article: Author response: Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging
Author response: Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging Open
View article: Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging
Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging Open
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury. The underlying molecular mechanisms responsible for…
View article: Alcohol-Associated Hepatitis: Translating Pathophysiology into Targeted Clinical Trials
Alcohol-Associated Hepatitis: Translating Pathophysiology into Targeted Clinical Trials Open
View article: Author response: R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
Author response: R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease Open
View article: R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease Open
Liver regeneration is impaired in patients suffering from alcohol-associated liver (ALD) diseases. Wnt ligands and their FZD receptors are dysregulated in diseased livers. R-spondin and their receptors are known to regulate Wnt activity vi…
View article: Seasonal Temperature Effects on EPS Composition and Sludge Settling Performance in Full-Scale Wastewater Treatment Plant: Mechanisms and Mitigation Strategies
Seasonal Temperature Effects on EPS Composition and Sludge Settling Performance in Full-Scale Wastewater Treatment Plant: Mechanisms and Mitigation Strategies Open
Seasonal temperature variations significantly impact biological wastewater treatment performance, particularly affecting extracellular polymeric substance (EPS) composition and sludge settling characteristics in activated sludge systems. T…
View article: <b>SIRT6 Is a Key Regulator of Pancreatic β-cell Survival and Function during Aging</b>
<b>SIRT6 Is a Key Regulator of Pancreatic β-cell Survival and Function during Aging</b> Open
Pancreatic β cells undergo senescence and loss during aging; however, the underlying mechanisms remain incompletely understood. This study aimed to investigate what sirtuin 6 (SIRT6) does during β cell aging. Pancreatic β-cell-speci…
View article: Tocilizumab combined with cyclophosphamide for the treatment of rapidly progressive refractory systemic sclerosis with predominant cardiac involvement: a case report
Tocilizumab combined with cyclophosphamide for the treatment of rapidly progressive refractory systemic sclerosis with predominant cardiac involvement: a case report Open
Systemic sclerosis (SSc) with multi-organ involvement poses significant therapeutic challenges. We present a case of rapidly progressive, refractory SSc with cardiac, musculoskeletal, and skin manifestations that was successfully managed w…
View article: Author response: Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging
Author response: Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging Open
View article: Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging Open
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury. The underlying molecular mechanisms responsible for…
View article: Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice
Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice Open
In United States, six million individuals with sub-Saharan ancestry carry two APOL1 high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants increase other diseases under dyslipidemia remains unclea…
View article: Sodium houttuyfonate prevents NiO-NPs induced lung injury in rats through the TNF-α/JAK-STAT signaling pathway
Sodium houttuyfonate prevents NiO-NPs induced lung injury in rats through the TNF-α/JAK-STAT signaling pathway Open
Nickel oxide nanomaterials (NiO-NPs), as engineered nanomaterials, are frequently implicated in the onset of various inflammatory disorders. However, no specific therapeutic agent is currently available for pneumonia induced by NiO-NPs exp…
View article: Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics? Open
Aging is a predominant risk factor for cardiovascular diseases. There is evidence demonstrating that senescent cells not only play a significant role in organism aging but also contribute to the pathogenesis of cardiovascular diseases in y…
View article: Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis
Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis Open
Background Aberrant mitochondrial metabolism is a key source of massive mitochondrial reactive oxygen species (mtROS) in tumour cells. Arginase-II (Arg-II), a widely expressed mitochondrial metabolic enzyme, has recently been shown to enha…
View article: Author response: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock
Author response: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock Open
View article: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock
Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock Open
The circadian clock enables organisms to synchronize biochemical and physiological processes over a 24 hr period. Natural changes in lighting conditions, as well as artificial disruptions like jet lag or shift work, can advance or delay th…
View article: R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease Open
Liver regeneration is impaired in patients suffering from alcohol-associated liver (ALD) diseases. Wnt ligands and their FZD receptors are dysregulated in diseased livers. R-spondin and their receptors are known to regulate Wnt activity vi…
View article: R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease
R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease Open
Liver regeneration is impaired in patients suffering from alcohol-associated liver (ALD) diseases. Wnt ligands and their FZD receptors are dysregulated in diseased livers. R-spondin and their receptors are known to regulate Wnt activity vi…
View article: Impact of Microplastics on Growth and Lipid Accumulation in Scenedesmus quadricauda
Impact of Microplastics on Growth and Lipid Accumulation in Scenedesmus quadricauda Open
Microplastics (MPs), as frequent pollutants, persist in aquatic environments and have an impact on the growth and biomass production of microalgae. This study employed MPs of polyethylene (PE), polystyrene (PS), and polypropylene (PP) at c…
View article: Sodium Houttuyfonate Prevents Nio-Nps Induced Lung Injury in Rats Through the Tnf-Α/Jak-Stat Signaling Pathway
Sodium Houttuyfonate Prevents Nio-Nps Induced Lung Injury in Rats Through the Tnf-Α/Jak-Stat Signaling Pathway Open
View article: Transformer-Based Multi-Player Tracking and Skill Recognition Framework for Volleyball Analytics
Transformer-Based Multi-Player Tracking and Skill Recognition Framework for Volleyball Analytics Open
Volleyball is a dynamic sport requiring high technical skills and tactical awareness, demanding effective training methods for performance improvement. Traditional training approaches often rely heavily on subjective analysis by coaches, l…
View article: Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice
Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice Open
Introduction In USA, six million individuals with Sub-Saharan ancestry carry two APOL1 high-risk variants, which increase the risk for kidney diseases. Whether APOL1 high-risk variants are independent risk factors for cardiovascular diseas…
View article: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock
Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock Open
The circadian clock enables organisms to synchronize biochemical and physiological processes over a 24-hour period. Natural changes in lighting conditions, as well as artificial disruptions like jet lag or shift work, can advance or delay …
View article: Author response: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock
Author response: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock Open
View article: Arginase-II gene deficiency reduces skeletal muscle aging in mice
Arginase-II gene deficiency reduces skeletal muscle aging in mice Open
Age-associated sarcopenia decreases mobility and is promoted by cell senescence, inflammation, and fibrosis. The mitochondrial enzyme arginase-II (Arg-II) plays a causal role in aging and age-associated diseases. Therefore, we aim to explo…
View article: R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease Open
Liver regeneration is impaired in patients suffering from alcohol-associated liver (ALD) diseases. Wnt ligands and their FZD receptors are dysregulated in diseased livers. R-spondin and their receptors are known to regulate Wnt activity vi…
View article: The correlation of acupuncture and moxibustion points for the treatment of diminished ovarian reserve and premature ovarian failure: A systematic review based on complex network
The correlation of acupuncture and moxibustion points for the treatment of diminished ovarian reserve and premature ovarian failure: A systematic review based on complex network Open
Background: Infertility rates have risen in recent years, with diminished ovarian reserve (DOR) affecting 10% of infertile women, accounting for approximately 20% of ovarian disorders. This highlights the importance of exploring effective …
View article: Mitochondrial quality control in alcohol-associated liver disease
Mitochondrial quality control in alcohol-associated liver disease Open
Excessive alcohol consumption is a leading cause of alcohol-associated liver disease (ALD), a significant global health concern with limited therapeutic options. Understanding the key factors contributing to ALD pathogenesis is crucial for…
View article: Evaluation and analysis of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in assessing therapeutic efficacy and pathological typing of patients with cervical cancer undergoing neoadjuvant chemotherapy
Evaluation and analysis of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in assessing therapeutic efficacy and pathological typing of patients with cervical cancer undergoing neoadjuvant chemotherapy Open
It was to demonstrate the therapeutic effects of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters (QPs) in cervical cancer (CC) patients undergoing neoadjuvant chemotherapy (NACT) and their role in eva…
View article: Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock
Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock Open
The circadian clock enables organisms to synchronize biochemical and physiological processes over a 24 hr period. Natural changes in lighting conditions, as well as artificial disruptions like jet lag or shift work, can advance or delay th…