Zhiyun Peng
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View article: Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis
Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis Open
Objective Osteoporosis (OP) is a systemic bone disease without effective treatment at present. The aim of this study is to explore the role of the circular RNA GCLC (circGCLC) in the osteogenic differentiation of bone marrow mesenchymal st…
View article: Application of double-row transfixion suture of the lower uterine segment in cesarean section for pernicious placenta previa complicated by placenta accreta spectrum: a comparative clinical study
Application of double-row transfixion suture of the lower uterine segment in cesarean section for pernicious placenta previa complicated by placenta accreta spectrum: a comparative clinical study Open
View article: Identification and antioxidant activities of chickpea albumin peptides and their fractions following fermentation by Bifidobacterium animalis subsp. lactis BB-12
Identification and antioxidant activities of chickpea albumin peptides and their fractions following fermentation by Bifidobacterium animalis subsp. lactis BB-12 Open
View article: Novel carbazole-oxadiazole derivatives as anti-α-glucosidase and anti-α-amylase agents: Design, synthesis, molecular docking, and biological evaluation
Novel carbazole-oxadiazole derivatives as anti-α-glucosidase and anti-α-amylase agents: Design, synthesis, molecular docking, and biological evaluation Open
View article: Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors
Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors Open
Thirteen kojic acid-coumarin derivatives were synthesized using the principle of molecular hybridization, and their structures were characterized by 1H NMR, 13C NMR, and HRMS. In vitro enzyme inhibition experiments showed that all newly sy…
View article: Synthesis, biological evaluation and action mechanism of 7H-[1,2,4] triazolo [3,4-b] [1,3,4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors
Synthesis, biological evaluation and action mechanism of 7H-[1,2,4] triazolo [3,4-b] [1,3,4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors Open
View article: Diagnostic, clustering, and immune cell infiltration analysis of m6A regulators in patients with sepsis
Diagnostic, clustering, and immune cell infiltration analysis of m6A regulators in patients with sepsis Open
View article: Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety
Tyrosinase inhibitory mechanism and anti-browning properties of novel kojic acid derivatives bearing aromatic aldehyde moiety Open
Kojic acid-aromatic aldehydes 6a-6m were synthesized and screened for their anti-tyrosinase activities. These compounds showed potently anti-tyrosinase activity with IC50 values in the range of 5.32 ± 0.23 to 77.89…
View article: An overview: metal-based inhibitors of urease
An overview: metal-based inhibitors of urease Open
Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms. Urease has important uses …
View article: Synthesis, α-glucosidase inhibition and molecular docking studies of natural product 2-(2-phenyethyl)chromone analogues
Synthesis, α-glucosidase inhibition and molecular docking studies of natural product 2-(2-phenyethyl)chromone analogues Open
A series of natural product (2-phenyethyl)chromone analogues (3–34) were designed, synthesized, and screened for their α-glucosidase inhibitory activity. The results indicated that some of the synthesized derivatives displayed inhibitory a…
View article: Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors
Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors Open
A series of litseaone B analogues 4a∼4p were synthesised and antitumor activities of all compounds were screened. These compounds were designed by introducing different substituents on the B ring. Among these synthesised compounds, …
View article: Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones
Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones Open
View article: Metagenomic next-generation sequencing in diagnosing <i>Pneumocystis jirovecii</i> pneumonia: A case report
Metagenomic next-generation sequencing in diagnosing <i>Pneumocystis jirovecii</i> pneumonia: A case report Open
It remains a huge challenge for clinicians to diagnose Pneumocystis jirovecii pneumonia (PJP) by a conventional method, which leads to delay in diagnosing PJP, accounting for higher mortality in patients with rheumatoid arthritis (RA). A 6…
View article: A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors Open
Microtubules play an important role in the process of cell mitosis and can form a spindle in the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then divide into two daughter cells to complete the proce…
View article: Potent eradication of mixed-species biofilms using photodynamic inactivation coupled with slightly alkaline electrolyzed water
Potent eradication of mixed-species biofilms using photodynamic inactivation coupled with slightly alkaline electrolyzed water Open
This study pioneered a novel anti-biofilm technology of photodynamic inactivation (PDI) coupled with slightly alkaline electrolyzed water (SAlEW) as solvent to dissolve photosensitizer, and its potency was verified through monitoring the b…
View article: Design, synthesis and biological evaluation of novel 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as potential anticancer agents and tubulin polymerization inhibitors
Design, synthesis and biological evaluation of novel 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as potential anticancer agents and tubulin polymerization inhibitors Open
A new series of 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as tubulin polymerization inhibitors were synthesized and evaluated for the anti-proliferative activities. All newly prepared compounds were tested for their antiproliferat…
View article: An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery
An overview of hydroxypyranone and hydroxypyridinone as privileged scaffolds for novel drug discovery Open
View article: Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors
Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors Open
A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities. These new compounds were evaluated for their in vitro a…
View article: Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors Open
A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent anti…
View article: Effects of ultrasound-assisted basic electrolyzed water (BEW) extraction on structural and functional properties of Antarctic krill (Euphausia superba) proteins
Effects of ultrasound-assisted basic electrolyzed water (BEW) extraction on structural and functional properties of Antarctic krill (Euphausia superba) proteins Open
A novel protein extraction method of ultrasound-assisted basic electrolyzed water (BEW) was proposed, and its effects on the structural and functional properties of Antarctic krill proteins were investigated. Results showed that BEW reduce…
View article: Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors
Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors Open
A novel series of 4-(4-methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines were designed, synthesized, and evaluated for their anticancer activities. Most of the synthesized compounds exhibited moderate to high antiproliferative activity in c…
View article: Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents
Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents Open
In this study, a novel series of isoxazole-naphthalene derivatives as tubulin polymerization inhibitors were designed, synthesized and evaluated for their anti-proliferative activities against human breast cancer cell line MCF-7. Most of t…
View article: Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site
Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site Open
A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7…
View article: Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors
Synthesis, Anticancer Activity and Molecular Modeling Studies of Novel Chalcone Derivatives Containing Indole and Naphthalene Moieties as Tubulin Polymerization Inhibitors Open
Eighteen novel chalcone derivatives containing indole and naphthalene moieties (2-19) were synthesized and characterized by 1H-NMR, 13C-NMR and high resolution (HR)-MS spectra. All compounds were evaluated for their in vitro cytotoxic pote…
View article: Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives
Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives Open
Benzothiazole-triazole derivatives 6a–6s have been synthesized and characterized by 1HNMR and 13C-NMR. All synthetic compounds were screened for their in vitro α-glucosidase inhibitory activity by using Baker’s yeast α-glucosidase enzyme. …
View article: Synthesis and biological evaluation of novel 2,4,5-triarylimidazole–1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors
Synthesis and biological evaluation of novel 2,4,5-triarylimidazole–1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors Open
View article: Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors Open
View article: Synthesis, <i>in vitro</i> evaluation and molecular docking studies of novel coumarin‐isatin derivatives as α‐glucosidase inhibitors
Synthesis, <i>in vitro</i> evaluation and molecular docking studies of novel coumarin‐isatin derivatives as α‐glucosidase inhibitors Open
This study synthesized a series of novel coumarin‐isatin derivatives and evaluated them for α‐glucosidase inhibitory activity. The majority of the screened compounds exhibited excellent inhibition activities with IC 50 values of 2.56 ± 0.0…
View article: Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as α-glucosidase inhibitors
Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as α-glucosidase inhibitors Open
View article: One-Pot and Three-Component Synthesis, Characterization and Biological Evaluation of Some New 1,2,4-Triazine-coumarins
One-Pot and Three-Component Synthesis, Characterization and Biological Evaluation of Some New 1,2,4-Triazine-coumarins Open
A series of 1,2,4-triazine-coumarins were prepared by a one-pot, three-component condensation of 1,2-diarylethane-1,2-diones, thiosemicarbazide and 2-coumaryloxy-methyloxiranes using K2CO3 as a catalyst in aqueous medium.This three-compone…