Zhijian Huang
YOU?
Author Swipe
View article: Elevated PEDF promotes the occurrence of diabetes mellitus via suppressing GSIS by downregulating the SNARE complex
Elevated PEDF promotes the occurrence of diabetes mellitus via suppressing GSIS by downregulating the SNARE complex Open
Type 2 diabetes mellitus (T2DM) is a major global public health burden. The mechanisms through which glucose-stimulated insulin secretion (GSIS) can be suppressed in individuals with obesity-derived type 2 diabetes mellitus (T2DM) have not…
View article: Barriers and enablers of HPV vaccination among caregivers of school-age girls in resource-limited regions of Western Sichuan, China: a mixed-methods study
Barriers and enablers of HPV vaccination among caregivers of school-age girls in resource-limited regions of Western Sichuan, China: a mixed-methods study Open
Background The HPV infection rate in Sichuan exceeds the national average. The provincial government has initiated vaccination programs, with a particular focus on impoverished areas such as the Ganzi, Aba, and Liangshan prefectures, where…
View article: Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation
Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation Open
Erectile dysfunction, a precursor to cardiovascular diseases, is linked to metabolic disorders like gout. However, whether hyperuricemia plays a direct causative role in erectile dysfunction is unclear. Here we show that clinical data from…
View article: Allergen sensitization patterns in children with allergic rhinitis: insights from a four-year retrospective study in Shenzhen, China
Allergen sensitization patterns in children with allergic rhinitis: insights from a four-year retrospective study in Shenzhen, China Open
Distinct allergen sensitization patterns in Shenzhen children with AR highlight the need for region-specific diagnostic panels and integrated care, supporting more personalized management and future research directions.
View article: The mediating role of thyroid-related hormones between thyroid dysfunction diseases and osteoporosis: a mediation mendelian randomization study
The mediating role of thyroid-related hormones between thyroid dysfunction diseases and osteoporosis: a mediation mendelian randomization study Open
View article: Complementary Perspectives Enhancement Via Hierarchical Graph Network for Multimodal Fake News Detection
Complementary Perspectives Enhancement Via Hierarchical Graph Network for Multimodal Fake News Detection Open
View article: Mm-Ghinet: A Multimodal Graph Hierarchical Network for Brain Disease Diagnosis
Mm-Ghinet: A Multimodal Graph Hierarchical Network for Brain Disease Diagnosis Open
View article: Batatasin-III protects cerebral vascular endothelium by regulating mitochondrial function and production of nitric oxide
Batatasin-III protects cerebral vascular endothelium by regulating mitochondrial function and production of nitric oxide Open
This study assessed the effect of batatasin-III on cerebral microvascular endothelial cell (EC) injury. Endothelial cell injury was induced in isolated cells by oxygenglucose deprivation/reperfusion (OGD/R) conditions. During 4 h of OGD in…
View article: CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2‐Atp7b signalling axis in depression after traumatic brain injury in a mouse model Open
Background Depression is a common but often overlooked consequence in individuals with post‐traumatic brain injury (TBI). Circular RNAs (circRNAs) play essential roles in the nervous system, yet their involvement in the cell death mechanis…
View article: Transcriptional dynamics and regulatory function of milRNAs in Ascosphaera apis invading Apis mellifera larvae
Transcriptional dynamics and regulatory function of milRNAs in Ascosphaera apis invading Apis mellifera larvae Open
In the present study, small RNA (sRNA) data from Ascosphaera apis were filtered from sRNA-seq datasets from the gut tissues of A. apis -infected Apis mellifera ligustica worker larvae, which were combined with the previously gained sRNA-se…
View article: Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer
Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer Open
Extracellular vesicles (EVs) were promising circulating biomarkers for multiple diseases, but whether serum EVs-derived proteins could be used as a reliable tumor biomarker for colorectal cancer (CRC) remained inconclusive. In this study, …
View article: SGCLDGA: unveiling drug–gene associations through simple graph contrastive learning
SGCLDGA: unveiling drug–gene associations through simple graph contrastive learning Open
Drug repurposing offers a viable strategy for discovering new drugs and therapeutic targets through the analysis of drug–gene interactions. However, traditional experimental methods are plagued by their costliness and inefficiency. Despite…
View article: Correction: A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer
Correction: A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer Open
View article: Feasibility and tolerability of eribulin-based chemotherapy versus other chemotherapy regimens for patients with metastatic triple-negative breast cancer: a single-centre retrospective study
Feasibility and tolerability of eribulin-based chemotherapy versus other chemotherapy regimens for patients with metastatic triple-negative breast cancer: a single-centre retrospective study Open
Background: Patients with Triple-negative breast cancer (TNBC) face a poor prognosis and limited therapeutic options. Current data on eribulin usage to treat TNBC is scarce. Therefore, we sought to compare the feasibility and tolerability …
View article: Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer
Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer Open
Background: The progression of tumors from less aggressive subtypes to more aggressive states during metastasis poses challenges for treatment strategies. Previous studies have revealed the molecular subtype conversion between primary and …
View article: A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer
A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer Open
Purpose This investigation sought to examine the efficacy and safety of low-dose apatinib used alongside chemotherapy in the clinical management of patients with metastatic triple-negative breast cancer (TNBC) within a real-world setting, …
View article: NPDI-BcCov: A Network Pharmacology Approach for Simultaneous Inference of Drugs Targeting Breast Cancer and COVID-19
NPDI-BcCov: A Network Pharmacology Approach for Simultaneous Inference of Drugs Targeting Breast Cancer and COVID-19 Open
The coronavirus disease (COVID-19) has emerged as a significant threat to public health, especially for individuals battling cancer. It is crucial to prioritize the care and attention given to breast cancer patients who have also infected …
View article: P1.04-01 CDK4/6 Inhibitor Improves Radioimmunotherapy Efficacy via Inducing PD-L1 Transcription through Increased c-Jun Activation in NSCLC
P1.04-01 CDK4/6 Inhibitor Improves Radioimmunotherapy Efficacy via Inducing PD-L1 Transcription through Increased c-Jun Activation in NSCLC Open
View article: Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (Apis cerana) Larval Guts
Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (Apis cerana) Larval Guts Open
Long non-coding RNAs (lncRNAs) are crucial modulators in a variety of biological processes, such as gene expression, development, and immune defense. However, little is known about the function of lncRNAs in the development of Asian honey …
View article: Identification novel Necroptosis-related LncRNAs to predict prognosis and screen the population benefiting from anti-PD-1/PDL-1 treatment in breast cancer
Identification novel Necroptosis-related LncRNAs to predict prognosis and screen the population benefiting from anti-PD-1/PDL-1 treatment in breast cancer Open
Background : Breast Cancer (BC) is the most common cancer in the world. The rapid development of tumor immunotherapy and necroptosis has brought new directions to the treatment of breast cancer. To improve the situation, this project aims …
View article: CircRNAs and their regulatory networks associated with the antioxidant enzymes and immune responses of Asian honey bee larvae to fungal infection
CircRNAs and their regulatory networks associated with the antioxidant enzymes and immune responses of Asian honey bee larvae to fungal infection Open
Non-coding RNA (ncRNA) plays an important role in the regulation of immune responses, growth, and development in plants and animals. Here, the identification, characteristic investigation, and molecular verification of circRNAs in Apis cer…
View article: Revealing the roles of TLR7, a nucleic acid sensor for COVID-19 in pan-cancer
Revealing the roles of TLR7, a nucleic acid sensor for COVID-19 in pan-cancer Open
Recent studies suggested that cancer was a risk factor for coronavirus disease 2019 (COVID-19). Toll-like receptor 7 (TLR7), a severe acute respiratory syndrome 2 (SARS-CoV-2) virus's nucleic acid sensor, was discovered to be aberrantly ex…
View article: Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period
Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period Open
Background Although the overall global incidence of gastric cancer has been declining, the number of new cases in people under the age of 50 is increasing, which is related to metastasis, late pathological stages, and poor prognosis. There…
View article: Systematic analysis of virus nucleic acid sensor DDX58 in malignant tumor
Systematic analysis of virus nucleic acid sensor DDX58 in malignant tumor Open
Introduction In December 2019, a novel epidemic of coronavirus pneumonia (COVID-19) was reported，and population-based studies had shown that cancer was a risk factor for death from COVID-19 infection. However, the molecular mechanism betwe…
View article: 5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis
5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis Open
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis. Dysregulation of 5-Methylcytosine (m 5 C) RNA has gradually been reported…
View article: Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer
Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer Open
Background: Cancer is the second cause of death worldwide. Copperoptosis is a new mode of regulated cell death and is strongly associated with metabolic pathways. FDX1 is a key gene that promotes copperoptosis, and its impact on tumor path…
View article: The cancer-associated fibroblast-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer
The cancer-associated fibroblast-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer Open
Background Gastric cancer (GC) is one of the most common cancers, with a wide range of symptoms and outcomes. Cancer-associated fibroblasts (CAFs) are newly identified in the tumor microenvironment (TME) and associated with GC progression,…
View article: Identification of Novel Immune Ferropotosis-Related Genes Associated With Clinical and Prognostic Features in Gastric Cancer
Identification of Novel Immune Ferropotosis-Related Genes Associated With Clinical and Prognostic Features in Gastric Cancer Open
Background Gastric cancer (GC) is the fifth commonest cancer and the third commonest reason of death causing by cancer worldwide. Currently, tumor immunology and ferropotosis develop rapidly that has made gastric cancer be treated in new d…
View article: CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates
CCDC134 as a Prognostic-Related Biomarker in Breast Cancer Correlating With Immune Infiltrates Open
Background The expression of Coiled-Coil Domain Containing 134(CCDC134) is up-regulated in different pan-cancer species. However, its prognostic value and correlation with immune infiltration in breast cancer are unclear. Therefore, we eva…
View article: HAUS5 Is A Potential Prognostic Biomarker With Functional Significance in Breast Cancer
HAUS5 Is A Potential Prognostic Biomarker With Functional Significance in Breast Cancer Open
Background Breast cancer (BRCA) has become the most frequently appearing, lethal, and aggressive cancer with increasing morbidity and mortality. Previously, it was discovered that the HAUS5 protein is involved in centrosome integrity, spin…