Zhenzhen Wen
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View article: Research progress on bacterial outer membrane vesicles in antibiotic resistance and clinical anti-infective therapy
Research progress on bacterial outer membrane vesicles in antibiotic resistance and clinical anti-infective therapy Open
In recent years, bacterial outer membrane vesicles (OMVs)—nanoscale, bilayered membrane structures secreted by Gram-negative bacteria—have attracted considerable attention for their involvement in antibiotic resistance and potential in cli…
View article: Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice
Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice Open
Overcoming immunosuppression in the tumor microenvironment (TME) is crucial for developing novel cancer immunotherapies. Here, we report that IL-16 administration enhances the polarization of T helper 1 (Th1) cells by inhibiting glutamine …
View article: CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages
CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages Open
Background Targeting oncogenic histone modification by histone deacetylase inhibitors (HDACis) demonstrates promising prospects in clinical cancer treatment, whereas a notable proportion of patients cannot benefit from HDACi therapy. This …
View article: Novel Efficient Steel Surface Defect Detection Model Based on ConvNeXt v2 and Squeeze Aggregated Excitation Attention
Novel Efficient Steel Surface Defect Detection Model Based on ConvNeXt v2 and Squeeze Aggregated Excitation Attention Open
With the rapid advancement of artificial intelligence and intelligent manufacturing technologies in recent years, automated inspection technologies have ushered in new opportunities for industrial production. Against this backdrop, this pa…
View article: Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer Open
View article: The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis
The role of exosomal molecular cargo in exosome biogenesis and disease diagnosis Open
Exosomes represent a type of extracellular vesicles derived from the endosomal pathway that transport diverse molecular cargoes such as proteins, lipids, and nucleic acids. These cargoes have emerged as crucial elements impacting disease d…
View article: Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells
Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells Open
Under aerobic conditions, the preferential use of anaerobic glycolysis by tumour cells leads to a high level of lactate accumulation in tumour microenvironment. Lactate acts not only as a cellular energy source but also as a signalling mol…
View article: Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation Open
View article: A Bibliometric Analysis of Publications on Endoscopic Ultrasound
A Bibliometric Analysis of Publications on Endoscopic Ultrasound Open
Background Over the past 40 years, endoscopic ultrasound (EUS) has become a safe and effective tool for both diagnostic and therapeutic applications. A growing number of articles have been published annually. We aimed to explore global sci…
View article: Development and Validation of Prognostic Nomogram for Primary Peritoneal Serous Carcinoma Compared With FIGO Staging System: A Population-Based Study
Development and Validation of Prognostic Nomogram for Primary Peritoneal Serous Carcinoma Compared With FIGO Staging System: A Population-Based Study Open
Background Primary peritoneal serous carcinoma (PPSC) is a rare tumor that lacks a prognostic prediction model. Our study aims to develop a nomogram to predict overall survival (OS) of PPSC patients. Methods Patients confirmed to have PPSC…
View article: RORβ suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway
RORβ suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway Open
Gastric cancer (GC) is the third leading cause of cancer‑related mortality and the fifth most common type of cancer worldwide. GC stem cells (GCSCs) have been reported to be responsible for the malignant behavior of GC. However, the key mo…
View article: BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy Open
TGFβ is essential for the generation of anti-tumor Th9 cells; on the other hand, it causes resistance against anti-tumor immunity. Despite recent progress, the underlying mechanism reconciling the double-edged effect of TGFβ signaling in T…
View article: Targeted versus universal tuberculosis chemoprophylaxis in 1968 patients with inflammatory bowel disease receiving anti‐TNF therapy in a tuberculosis endemic region
Targeted versus universal tuberculosis chemoprophylaxis in 1968 patients with inflammatory bowel disease receiving anti‐TNF therapy in a tuberculosis endemic region Open
Summary Background Anti‐tumour necrosis factor (anti‐TNF) therapy increases the risk of tuberculosis (TB). Given limitations of screening techniques, it remains uncertain if patients receiving anti‐TNF in TB endemic regions should be scree…
View article: Ruxolitinib combined with doxorubicin, etoposide, and dexamethasone for the treatment of the lymphoma-associated hemophagocytic syndrome
Ruxolitinib combined with doxorubicin, etoposide, and dexamethasone for the treatment of the lymphoma-associated hemophagocytic syndrome Open
View article: Downregulation of miR‑3934‑5p enhances A549 cell sensitivity to cisplatin by targeting TP53INP1
Downregulation of miR‑3934‑5p enhances A549 cell sensitivity to cisplatin by targeting TP53INP1 Open
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) is a tumor suppressor associated with malignant tumor metastasis. In addition, it has been reported that hsa-microRNA (miR)-3934 serves key roles in various types of lung cancer, inc…
View article: Comparative Transcriptomic Analysis of Vernalization- and Cytokinin-Induced Floral Transition in Dendrobium nobile
Comparative Transcriptomic Analysis of Vernalization- and Cytokinin-Induced Floral Transition in Dendrobium nobile Open
Vernalization is required for floral initiation in Dendrobium . Interestingly, those beneficial effects can also be achieved by exogenous cytokinin application in greenhouses. Thus, an as yet unknown crosstalk/interaction may exist between…
View article: Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ
Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ Open
View article: Risk of tuberculosis during infliximab therapy for inflammatory bowel disease, rheumatoid arthritis, and spondyloarthropathy: A meta-analysis
Risk of tuberculosis during infliximab therapy for inflammatory bowel disease, rheumatoid arthritis, and spondyloarthropathy: A meta-analysis Open
Infliximab is a promising drug with good outcomes demonstrated for diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and spondyloarthropathy (SpA). However, treatment with this drug may increase the risk of tuber…
View article: Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells
Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells Open
Gastric cancer stem cells (GCSCs) have an important role in metastasis and recurrence of gastric cancer, and novel treatment strategies that target GCSCs are urgently required. Although evodiamine (Evo), a derivative of the traditional her…
View article: Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)
Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review) Open
Nuclear receptors are a superfamily of transcription factors including the steroid hormone receptors, non-steroid hormone receptors and the orphan nuclear receptor family. Retinoic acid-related orphan receptor (ROR)β, as a member of the or…