Gan Zhang
YOU?
Author Swipe
View article: Involvement of bile acids in cholangiocarcinoma progression <i>via</i> the Hippo-yes-associated protein signaling pathway
Involvement of bile acids in cholangiocarcinoma progression <i>via</i> the Hippo-yes-associated protein signaling pathway Open
BACKGROUND Cholangiocarcinoma (CCA) is a highly aggressive malignancy with limited therapeutic options. Dysregulation of the Hippo-yes-associated protein (YAP) signaling pathway plays a key role in tumor progression, but the effects of dis…
View article: Where the river turns old: Urbanized deltas imprint a fossil signature on black carbon exported to the ocean
Where the river turns old: Urbanized deltas imprint a fossil signature on black carbon exported to the ocean Open
Black carbon (BC) from biomass burning is a key component of the global carbon cycle, and radiocarbon (14C) age of riverine BC is used to constrain its terrestrial residence time. However, whether 14C-free BC from fossil fuel combustion si…
View article: Mechanisms and pathways of ROS and autophagy in thyroid cancer
Mechanisms and pathways of ROS and autophagy in thyroid cancer Open
Thyroid cancer stands as one of the prevalent malignancies, with generally optimistic prognoses for many patients. However, challenges such as drug resistance and radioiodine 131I tolerance have surfaced, posing hurdles to effec…
View article: Effect of Fascia Iliaca Compartment Block with Liposomal Bupivacaine on the Quality of Recovery After Hip Fracture Surgery: A Prospective, Randomized, Controlled Clinical Study
Effect of Fascia Iliaca Compartment Block with Liposomal Bupivacaine on the Quality of Recovery After Hip Fracture Surgery: A Prospective, Randomized, Controlled Clinical Study Open
Fascia iliaca compartment block with liposomal bupivacaine can significantly improve the quality of postoperative recovery and reduce opioid consumption in patients undergoing hip fracture surgery.
View article: Polycyclic nitroaromatic compounds in HULIS as dominant pro-apoptotic agents in PM2.5: Biomass/coal combustion sources, structural insights, and biomarker discovery
Polycyclic nitroaromatic compounds in HULIS as dominant pro-apoptotic agents in PM2.5: Biomass/coal combustion sources, structural insights, and biomarker discovery Open
Identifying the toxic components in PM2.5 is crucial for effective air pollution control, yet it remains a challenge due to the presence of numerous unidentified organic compounds. In this study, correlation analysis between the…
View article: Source diagnostic assessment of dissolved black carbon in selected lacustrine systems of northern Pakistan
Source diagnostic assessment of dissolved black carbon in selected lacustrine systems of northern Pakistan Open
Context Incomplete pyrolysis of biomass and fossil fuel generates black carbon (BC), which is deposited and stored in glaciers and soils for long residence times. BC is mobilised from its terrestrial pools because of physicochemical events…
View article: Real-time UAV-based wheat lodging detection via edge-accelerated improved Mask-RT-DETR
Real-time UAV-based wheat lodging detection via edge-accelerated improved Mask-RT-DETR Open
View article: Supplementary material to "Constraining urban biogenic CO <sub>2</sub> fluxes: Composition, seasonality and drivers from radiocarbon and inventory analysis"
Supplementary material to "Constraining urban biogenic CO <sub>2</sub> fluxes: Composition, seasonality and drivers from radiocarbon and inventory analysis" Open
View article: Constraining urban biogenic CO <sub>2</sub> fluxes: Composition, seasonality and drivers from radiocarbon and inventory analysis
Constraining urban biogenic CO <sub>2</sub> fluxes: Composition, seasonality and drivers from radiocarbon and inventory analysis Open
Urban areas play a pivotal role in achieving net-zero emissions to limit global warming to 1.5 °C, given their high carbon footprint and mitigation potential. Accurate quantification of urban CO2 sources is essential for effective carbon b…
View article: Multi-element dataset of soil profiles across climatic zones in China's mountains
Multi-element dataset of soil profiles across climatic zones in China's mountains Open
Datasets of soil multi-element concentrations are essential for advancing our understanding of ecological functioning and responses to global change in mountain regions. However, the paucity of such datasets represents a fundamental impedi…
View article: Wastewater-based epidemiology empowered by o-DGT passive sampling: Quantifying pharmaceuticals consumption hotspots in rural China’s untreated watersheds
Wastewater-based epidemiology empowered by o-DGT passive sampling: Quantifying pharmaceuticals consumption hotspots in rural China’s untreated watersheds Open
The lack of centralized sewage treatment in rural areas has led to severe underestimation of pharmaceutical pollution, posing significant risks to aquatic ecosystems and human health. While wastewater-based epidemiology (WBE) is widely use…
View article: Human influence on recent trends in extratropical low-level wind speed
Human influence on recent trends in extratropical low-level wind speed Open
Trends in atmospheric circulation have begun to emerge in recent decades. Summertime mean circulation trends aloft have been attributed to human influence, but discrepancies exist for wintertime. For low-level extreme winds, it remains unc…
View article: Substantial reductions in black carbon from both fossil fuels and biomass burning during China’s Clean Air Action
Substantial reductions in black carbon from both fossil fuels and biomass burning during China’s Clean Air Action Open
Black carbon (BC) aerosols exacerbate air pollution and climate warming, but their climatic impacts and sources are poorly constrained by bottom–up emission inventories (EIs). China’s Clean Air Action (CAA), which was launched in 2013, pro…
View article: Evaluating maize emergence quality with multi-task YOLO11-Mamba and UAV-RGB remote sensing
Evaluating maize emergence quality with multi-task YOLO11-Mamba and UAV-RGB remote sensing Open
View article: Continental-scale impact of bomb radiocarbon affects historical fossil fuel carbon dioxide reconstruction
Continental-scale impact of bomb radiocarbon affects historical fossil fuel carbon dioxide reconstruction Open
Historical reconstructions of fossil fuel carbon dioxide emissions are vital to setting emission mitigation strategies, and tree-ring radiocarbon analysis provides a reliable approach. However, residual radiocarbon from past nuclear tests …
View article: Navigating the Shadows
Navigating the Shadows Open
View article: Z-YOLO: an apple object detection algorithm in orchard scenarios based on improved YOLOv11
Z-YOLO: an apple object detection algorithm in orchard scenarios based on improved YOLOv11 Open
View article: Multi-Element Dataset Across Diverse Climatic Zones and Soil Profiles in China’s Mountains
Multi-Element Dataset Across Diverse Climatic Zones and Soil Profiles in China’s Mountains Open
Mountain ecosystems are crucial for global biodiversity conservation and climate regulation, yet their response to environmental change remains poorly understood due to limited high-resolution, multi-element datasets. Here, we present a co…
View article: Aqueous secondary formation substantially contributes to hydrophilic organophosphate esters in aerosols
Aqueous secondary formation substantially contributes to hydrophilic organophosphate esters in aerosols Open
View article: TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis
TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis Open
View article: Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness
Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness Open
GAA can significantly enhance the anticancer effects of DDP on GBC cells by inhibiting DNA damage response and cell stemness, supporting GAA as an adjuvant treatment for GBC and warrants further validatory preclinical studies.
View article: The Intrinsic Link between Optical Properties and Toxicity of Extractable Organic Matter in Combustion Particles: Mediated by Polycyclic Aromatic Compounds
The Intrinsic Link between Optical Properties and Toxicity of Extractable Organic Matter in Combustion Particles: Mediated by Polycyclic Aromatic Compounds Open
Organic compounds are important contributors to the optical properties and health effects of combustion-derived particles. However, the connection between optical properties and toxicity of combustion particles remains a matter of little c…
View article: Polycyclic aromatics in the Chang’E 5 lunar soils
Polycyclic aromatics in the Chang’E 5 lunar soils Open
Polycyclic aromatics are ubiquitous in the interstellar medium and meteorites, yet the search for lunar polycyclic aromatics remains a significant challenge. Here, we analyze Chang’E-5 lunar soil samples, revealing polycyclic aromatic conc…
View article: Temporal Variations and Source Apportionment of Biomass Burning and Biogenic Organic Aerosols in the Pearl River Delta: Effects of the Monsoon, Plant Phenology, and Anthropogenic Activities
Temporal Variations and Source Apportionment of Biomass Burning and Biogenic Organic Aerosols in the Pearl River Delta: Effects of the Monsoon, Plant Phenology, and Anthropogenic Activities Open
Biomass burning (BB) and biogenic emissions significantly influence the chemical compositions of organic aerosols (OAs). In this study, aerosol samples collected throughout the year from a regional receptor site in the Pearl River Delta (P…
View article: High-throughput phenotyping techniques for forage: Status, bottleneck, and challenges
High-throughput phenotyping techniques for forage: Status, bottleneck, and challenges Open
High-throughput phenotyping (HTP) technology is now a significant bottleneck in the efficient selection and breeding of superior forage genetic resources. To better understand the status of forage phenotyping research and identify key dire…
View article: Wastewater-Based Epidemiology Empowered by O-Dgt Passive Sampling: Quantifying Antibiotic Consumption Hotspots in Rural China's Untreated Watersheds
Wastewater-Based Epidemiology Empowered by O-Dgt Passive Sampling: Quantifying Antibiotic Consumption Hotspots in Rural China's Untreated Watersheds Open
View article: Elevated Wet Deposition of Micro- and Nano-Plastics in Remote Mountains Driven by Free Tropospheric Transport
Elevated Wet Deposition of Micro- and Nano-Plastics in Remote Mountains Driven by Free Tropospheric Transport Open
View article: DTX3L Promotes Intrahepatic Cholangiocarcinoma Progression Through P53 Ubiquitination-Mediated Inhibition of ER Stress and Apoptosis
DTX3L Promotes Intrahepatic Cholangiocarcinoma Progression Through P53 Ubiquitination-Mediated Inhibition of ER Stress and Apoptosis Open
View article: Polycyclic Nitroaromatic Compounds in Water-Soluble Humic-Like Substances are the Key Components to Induce Apoptosis in Pm2.5
Polycyclic Nitroaromatic Compounds in Water-Soluble Humic-Like Substances are the Key Components to Induce Apoptosis in Pm2.5 Open
View article: Unveiling the nexus of p53 and PD-L1: insights into immunotherapy resistance mechanisms in hepatocellular carcinoma
Unveiling the nexus of p53 and PD-L1: insights into immunotherapy resistance mechanisms in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer worldwide, continues to pose a substantial health challenge with limited treatment options for advanced stages. Despite progress in therapies such as surgery, tra…