Zhiling Sun
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View article: Integrated plasma and synovial membrane lipidomic profiling revealing the therapeutic effects of moxibustion in collagen-induced arthritis rat models
Integrated plasma and synovial membrane lipidomic profiling revealing the therapeutic effects of moxibustion in collagen-induced arthritis rat models Open
Objective: To reveal the therapeutic effects of moxibustion in collagen-induced arthritis (CIA) rat models using the combined analysis of plasma and synovial membrane lipidomic profiling and to enhance the understanding of how moxibustion …
View article: The role of artificial intelligence in shaping nursing education: A comprehensive systematic review
The role of artificial intelligence in shaping nursing education: A comprehensive systematic review Open
PROSPERO ID: CRD42024562849.
View article: Design, synthesis and antiviral activity of coumarin derivatives containing 1,3,4- oxadiazole/thidiazole
Design, synthesis and antiviral activity of coumarin derivatives containing 1,3,4- oxadiazole/thidiazole Open
In this paper, a series of oxadiazole/thidiazole containing coumarin derivative derivatives were designed, synthesized and characterized using NMR and HRMS. The evaluation of antiviral activity revealed that some of the synthesized compoun…
View article: Design and research of new virulence factor inhibitors for plant bacterial disease control
Design and research of new virulence factor inhibitors for plant bacterial disease control Open
In this work, various chalcone derivatives incorporating piperazine-isopropanolamine were elaborately designed and synthesized. The antibacterial efficacy revealed that compound Z6 showed notable biological activity, with a median effectiv…
View article: Anti-TMV activity of flavonol derivatives containing piperidine sulfonamide: Design, synthesis, mechanism study
Anti-TMV activity of flavonol derivatives containing piperidine sulfonamide: Design, synthesis, mechanism study Open
A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC50 values for the curative of tobacco mosaic virus (TMV) by Z6 and Z22 were 108.2 and 102.7 μg/mL, respectively, outperforming the cont…
View article: Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation
Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation Open
In order to discover novel compounds with excellent agricultural activities, novel flavonol derivatives containing 1,3,4-thiadiazole were synthesized and evaluated for their antifungal activities. The bioassay results showed that some of t…
View article: Bacteria Affect the Distribution of Soil-Dissolved Organic Matter on the Slope: A Long-Term Experiment in Black Soil Erosion
Bacteria Affect the Distribution of Soil-Dissolved Organic Matter on the Slope: A Long-Term Experiment in Black Soil Erosion Open
Soil erosion results in dissolved organic matter (DOM) loss and is one of the main paths of soil carbon loss. Bacteria affect the generation and transformation of DOM. However, the effect of bacteria on the composition and slope distributi…
View article: Investigating causal associations among gut microbiota, metabolites, and psoriatic arthritis: a Mendelian randomization study
Investigating causal associations among gut microbiota, metabolites, and psoriatic arthritis: a Mendelian randomization study Open
Background Currently, there has been observed a significant alteration in the composition of the gut microbiome (GM) and serum metabolites in patients with psoriatic arthritis (PsA) compared to healthy individuals. However, previous observ…
View article: Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity
Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity Open
A series of flavonol derivatives containing quinazolinone were designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV) were evaluated. The results of the half maximal effective concentration (EC 50 ) tes…
View article: Novel flavonoid derivatives containing 1,2,4-triazolo[4,3-a]pyridine as potential antifungal agents: Design, synthesis, and biological evaluation
Novel flavonoid derivatives containing 1,2,4-triazolo[4,3-a]pyridine as potential antifungal agents: Design, synthesis, and biological evaluation Open
A series of flavonoid derivatives containing 1,2,4-triazolo[4,3-a]pyridine were designed, synthesized and evaluated for their antifungal activity. Bioactivity tests showed that some target compounds exhibited the strong antifungal activity…
View article: Design, synthesis, antibacterial and antiviral evaluation of chalcone derivatives containing benzoxazole
Design, synthesis, antibacterial and antiviral evaluation of chalcone derivatives containing benzoxazole Open
In this study, 24 chalcone derivatives containing benzoxazole were designed and synthesized, and the structures of all target compounds were confirmed by NMR and HRMS. The results of antibacterial activity showed that the median effective …
View article: Design, synthesis, and antiviral activities of myricetin derivatives containing phenoxypyridine
Design, synthesis, and antiviral activities of myricetin derivatives containing phenoxypyridine Open
A series of myricetin derivatives containing phenoxypyridine structure were designed and synthesized on the basis of the natural product myricitrin, which were structurally characterized on NMR and HRMS. The results of antiviral activity t…
View article: Effect of Moxibustion on Inflammatory Cytokines for Low Back Pain: A Systematic Review, Meta-Analysis and Meta-Regression
Effect of Moxibustion on Inflammatory Cytokines for Low Back Pain: A Systematic Review, Meta-Analysis and Meta-Regression Open
For LBP, moxibustion can effectively decrease levels of IL-1, IL-1β, IL-6, IL-12, IL-17, IL-23, and TNF-α to achieve analgesia. Because the side effects of moxibustion are transient, it is relatively safe for clinical use. However, based o…
View article: Anti-osteoporosis mechanism of resistance exercise in ovariectomized rats based on transcriptome analysis: a pilot study
Anti-osteoporosis mechanism of resistance exercise in ovariectomized rats based on transcriptome analysis: a pilot study Open
Postmenopausal osteoporosis is the main cause of fractures in women. Resistance exercise has a positive effect on bone mineral density in postmenopausal osteoporosis patients, but its mechanism is unclear. The purpose of this study was to …
View article: Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide
Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide Open
In this paper, a series of derivatives were synthesized by introducing the pharmacophore pyrazole ring and piperazine ring into the structure of the natural product myricetin through an amide bond. The structures were determined using carb…
View article: Design, Synthesis and Antifungal Activity of Novel 1,4-Pentadiene-3-one Containing Quinazolinone
Design, Synthesis and Antifungal Activity of Novel 1,4-Pentadiene-3-one Containing Quinazolinone Open
Twenty 1,4-pentadiene-3-one derivatives containing quinazolinone (W1–W20) were designed and synthesized. The bioactivity test results showed that some compounds had antifungal activities in vitro. W12 showed excellent bioactivity against S…
View article: Integrated multiplex network based approach reveled CC and CXC chemokines associated key biomarkers in colon adenocarcinoma patients.
Integrated multiplex network based approach reveled CC and CXC chemokines associated key biomarkers in colon adenocarcinoma patients. Open
Colon adenocarcinoma (COAD) is a prevalent and aggressive form of cancer that necessitates the identification of robust biomarkers for early diagnosis and treatment. Therefore, this project was launched to identify a few key biomarkers fro…
View article: The Effect and Safety of Thunder-Fire Moxibustion for Low Back Pain: A Meta-Analysis of Randomized Controlled Trials
The Effect and Safety of Thunder-Fire Moxibustion for Low Back Pain: A Meta-Analysis of Randomized Controlled Trials Open
Background. Low back pain (LBP) is considered the leading cause of people living with years of disability worldwide. Notably, thunder-fire moxibustion (TFM) is a new type of moxibustion, which has been widely applied to treat pain syndrome…
View article: Metabolomics study of biochemical changes in the serum and articular synovium tissue of moxibustion in rats with collagen-induced arthritis
Metabolomics study of biochemical changes in the serum and articular synovium tissue of moxibustion in rats with collagen-induced arthritis Open
To demonstrate the rheumatoid arthritis (RA) mechanisms by determining the biochemical changes. To investigate the therapeutic mechanism of moxibustion in RA-model rats using a gas chromatography-mass spectrometry (GC–MS) metabolomics appr…
View article: Multi-omics Analysis at Serum Proteomic and Metabolomic Levels Reveals Mechanisms of Moxibustion for a Mouse Model of Ankylosing Spondylitis
Multi-omics Analysis at Serum Proteomic and Metabolomic Levels Reveals Mechanisms of Moxibustion for a Mouse Model of Ankylosing Spondylitis Open
Background: Moxibustion is widely used in ameliorating symptoms of ankylosing spondylitis (AS). The aim of this study was to identify the potential molecular profiles of moxibustion on relieving AS mice through incorporating ultra-high-per…
View article: Effectiveness of Virtual Reality in Nursing Education: Meta-Analysis
Effectiveness of Virtual Reality in Nursing Education: Meta-Analysis Open
Background Virtual reality (VR) is the use of computer technology to create an interactive three-dimensional (3D) world, which gives users a sense of spatial presence. In nursing education, VR has been used to help optimize teaching and le…
View article: Effectiveness of Virtual Reality in Nursing Education: Meta-Analysis (Preprint)
Effectiveness of Virtual Reality in Nursing Education: Meta-Analysis (Preprint) Open
BACKGROUND Virtual reality (VR) is the use of computer technology to create an interactive three-dimensional (3D) world, which gives users a sense of spatial presence. In nursing education, VR has been used to help optimize teaching and l…
View article: Enhancement of radiotherapy efficacy by pleiotropic liposomes encapsulated paclitaxel and perfluorotributylamine
Enhancement of radiotherapy efficacy by pleiotropic liposomes encapsulated paclitaxel and perfluorotributylamine Open
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, the efficacy of chemoradiotherapy is limited by the hostility of the tumor microenvironment such as hypoxia. To overcome this constraint, we…