Gang Chen
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View article: The overexpression of HOXC6 in LUSC and pan-squamous cell carcinomas indicates the coexistence of nuclear division regulatory mechanisms
The overexpression of HOXC6 in LUSC and pan-squamous cell carcinomas indicates the coexistence of nuclear division regulatory mechanisms Open
Background Homeobox C6 (HOXC6) shows abnormal expression in various tumors, but its pattern in lung squamous cell carcinoma (LUSC) remains unclear. Objective To investigate HOXC6's expression and function in LUSC. Methods HOXC6 expression …
View article: Effects of different doses of pentazocine on heart rate variability and recovery quality in patients treated with percutaneous transhepatic cholangial drainage
Effects of different doses of pentazocine on heart rate variability and recovery quality in patients treated with percutaneous transhepatic cholangial drainage Open
View article: Pooled data from phase 3 clinical trials comparing the clinical activity of ceftolozane/tazobactam versus meropenem for the treatment of complicated intra-abdominal infections
Pooled data from phase 3 clinical trials comparing the clinical activity of ceftolozane/tazobactam versus meropenem for the treatment of complicated intra-abdominal infections Open
The efficacy of C/T plus metronidazole was comparable with meropenem even for cIAIs and C/T plus metronidazole might be an alternative treatment option for cIAI.
View article: Metabolomic and bioactivity analysis of plum pulp fermented with Lactiplantibacillus, Lacticaseibacillus, and Bifidobacterium strains
Metabolomic and bioactivity analysis of plum pulp fermented with Lactiplantibacillus, Lacticaseibacillus, and Bifidobacterium strains Open
Probiotic fermentation is a promising method for enhancing fruit functionality. This study investigated the effects of Lactiplantibacillus plantarum, Lacticaseibacillus paracasei, and Bifidobacterium infantis fermentat…
View article: Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration.
Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration. Open
This study identified RAC3 as a key HCC oncogenic driver; its overexpression links to poor prognosis/resistance. Targeting the RAC3/E2F1 axis offers a new therapy, which highlights RAC3 as a biomarker/target.
View article: Lactation abnormality during breastfeeding in a patient with Chanarin-Dorfman syndrome: A new clinical symptom?
Lactation abnormality during breastfeeding in a patient with Chanarin-Dorfman syndrome: A new clinical symptom? Open
Introduction: Chanarin–Dorfman syndrome (CDS) is a rare genetic disorder caused by impaired lipid metabolism, leading to the accumulation of lipid vacuoles in various types of cells. CDS is characterized by multi-organ involvement, most no…
View article: Single-Cell eQTL Mapping Reveals Cell Type-Specific Genetic Regulation in Lung Cancer
Single-Cell eQTL Mapping Reveals Cell Type-Specific Genetic Regulation in Lung Cancer Open
Genome-wide association studies (GWAS) have identified over 50 lung cancer risk loci; however, the precise cellular context of these genetic mechanisms remains unclear due to limitations in bulk tissue eQTL analyses. Here, we present the l…
View article: Mid-term outcomes of complex TASC D lesions involving the common femoral artery bifurcation
Mid-term outcomes of complex TASC D lesions involving the common femoral artery bifurcation Open
Objective The aim of this study was to evaluate the efficacy of hybrid therapy and endovascular therapy in the treatment of complex femoropopliteal Trans-Atlantic Inter-Society Consensus II D（TASC D） lesions involving the common femoral ar…
View article: Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene <i>Zeste White 10</i> in Hepatocellular Carcinoma
Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene <i>Zeste White 10</i> in Hepatocellular Carcinoma Open
ZW10 is considered a TKI-resistant and tumor-supportive gene, which is also a promising novel prognostic biomarker for HCC or a therapeutic target for overcoming TKI resistance.
View article: Modifiable Factors Underlying Caregivers’ Psychological Support Needs in Pediatric Disability: Through the Lens of Psycho-Behavioral and Social–Environmental Interactions
Modifiable Factors Underlying Caregivers’ Psychological Support Needs in Pediatric Disability: Through the Lens of Psycho-Behavioral and Social–Environmental Interactions Open
Background/Objectives: Childhood disability is a major stressor for caregivers. There are many problems and challenges in relation to satisfying the psychological support needs of caregivers. This study aims to explore the modifiable psych…
View article: CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11
CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11 Open
View article: Not All Data are Good Labels: On the Self-supervised Labeling for Time Series Forecasting
Not All Data are Good Labels: On the Self-supervised Labeling for Time Series Forecasting Open
Time Series Forecasting (TSF) is a crucial task in various domains, yet existing TSF models rely heavily on high-quality data and insufficiently exploit all available data. This paper explores a novel self-supervised approach to re-label t…
View article: Tumour surface regularity predicts survival and benefit from gross total resection in IDH-wildtype glioblastoma patients
Tumour surface regularity predicts survival and benefit from gross total resection in IDH-wildtype glioblastoma patients Open
Objectives To evaluate the ability of sphericity in glioblastomas (GBMs) for predicting overall survival (OS) and the survival benefit from gross tumour resection (GTR). Methods Preoperative MRI scans were retrospectively analysed in IDH-w…
View article: Point-of-Care Ultrasound (POCUS) Exam Performed by an Anesthesiologist Changes Obstetric Management
Point-of-Care Ultrasound (POCUS) Exam Performed by an Anesthesiologist Changes Obstetric Management Open
Point-of-care ultrasound (POCUS) exams have been shown to impact perioperative patient care. Involvement in antepartum obstetric patients has not been previously described. We report a case of a parturient with chronic hypertension in new-…
View article: A case report of gallstone ileus caused by biliary-intestinal fistula: Multidetector computed tomography features analysis
A case report of gallstone ileus caused by biliary-intestinal fistula: Multidetector computed tomography features analysis Open
View article: Prognostic analysis of helical tomotherapy stereotactic body radiotherapy in multiple primary or second primary lung cancers
Prognostic analysis of helical tomotherapy stereotactic body radiotherapy in multiple primary or second primary lung cancers Open
HT-SBRT may be a safe and effective treatment for MPLCs and SPLC, though prospective studies are needed to confirm its efficacy.
View article: TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma Open
View article: GILT stabilizes cofilin to promote the metastasis of prostate cancer
GILT stabilizes cofilin to promote the metastasis of prostate cancer Open
Gamma-interferon-induced lysosomal thiol reductase (GILT), known for catalyzing disulfide bond reduction, is involved in various physiological processes. While the involvement of GILT in the development of various tumors has been demonstra…
View article: The Type III Secretion System (T3SS) of <i>Escherichia Coli</i> Promotes Atherosclerosis in Type 2 Diabetes Mellitus
The Type III Secretion System (T3SS) of <i>Escherichia Coli</i> Promotes Atherosclerosis in Type 2 Diabetes Mellitus Open
Large‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence …
View article: Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish
Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish Open
The present study provides preliminary evidence on the potential mechanisms of combined exposure-induced multi-organ toxicity, highlighting ferroptosis of the liver and apoptosis of the ovary as key pathways. These findings provide new per…
View article: Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodies: a pilot study
Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodies: a pilot study Open
This retrospectively study was approved by the Ethics Committee of Tongji Hospital, Wuhan, China (TJ-IRB20230729).
View article: Discovery of a Novel Selective PAK1/HDAC6/HDAC10 Inhibitor ZMF-25 that Induces Mitochondrial Metabolic Breakdown and Autophagy-Related Cell Death in Triple-Negative Breast Cancer
Discovery of a Novel Selective PAK1/HDAC6/HDAC10 Inhibitor ZMF-25 that Induces Mitochondrial Metabolic Breakdown and Autophagy-Related Cell Death in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and addressing its intrinsic heterogeneity has emerged as a valuable avenue for novel clinical treatment strategy. Here, we put forward an innovative strate…
View article: 125 - Long-term safety and efficacy of intravesical autologous emulsified fat (Nanofat) plus platelet-rich plasma grafting in the treatment of refractory interstitial cystitis/bladder pain syndrome: A prospective, observational study
125 - Long-term safety and efficacy of intravesical autologous emulsified fat (Nanofat) plus platelet-rich plasma grafting in the treatment of refractory interstitial cystitis/bladder pain syndrome: A prospective, observational study Open
View article: SLC41A1 overexpression correlates with immune cell infiltration in HCC and promotes its malignant progression
SLC41A1 overexpression correlates with immune cell infiltration in HCC and promotes its malignant progression Open
Solute carrier 41 (SLC41) has been identified as a family of magnesium (Mg2+) transporters that participate in various diseases, including tumor development and progression. Recent studies revealed SLC41A3 acted as an oncogene a…
View article: Changes in the nutritional, flavor, and phytochemical properties of Citrus reticulata Blanco cv. ‘Dahongpao’ whole fruits during enzymatic hydrolysis and fermentation
Changes in the nutritional, flavor, and phytochemical properties of Citrus reticulata Blanco cv. ‘Dahongpao’ whole fruits during enzymatic hydrolysis and fermentation Open
Introduction Currently, the large-scale consumption of fresh citrus fruits in the form of juices, jams, and purees results in significant quantities of waste consisting of citrus peels, pulp, and seeds. Methods To improve the utilization r…
View article: An analysis of the clinical significance of the TKI-resistant gene ZNF687 for hepatocellular carcinoma patients
An analysis of the clinical significance of the TKI-resistant gene ZNF687 for hepatocellular carcinoma patients Open
ZNF687 represents a TKI-resistant and growth-dependent gene for HCC, the overexpression of which indicates poor OS for HCC patients. Additionally, ZNF687 is expected to be a druggable target for overcoming TKI resistance, and chaetocin may…
View article: Pig-to-human kidney xenotransplants using genetically modified minipigs
Pig-to-human kidney xenotransplants using genetically modified minipigs Open
This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression. Two brain-dead patients undergo single kidney xenotran…
View article: Clinical significance of the modified Naples prognostic score in patients with stage II-III colon cancer undergoing curative resection: a retrospective study from the real world
Clinical significance of the modified Naples prognostic score in patients with stage II-III colon cancer undergoing curative resection: a retrospective study from the real world Open
Background The Naples prognostic score (NPS) determined by the nutritional and inflammatory condition of an individual is attracting growing attention for predicting postoperative outcomes in a variety of malignancies. The study aimed to a…
View article: Comparative analysis of PD-L1 expression and molecular alterations in primary versus metastatic lung adenocarcinoma: a real-world study in China
Comparative analysis of PD-L1 expression and molecular alterations in primary versus metastatic lung adenocarcinoma: a real-world study in China Open
Objectives Programmed death-ligand 1 (PD-L1) is the only Food and Drug Administration-approved biomarker for monitoring response to immune checkpoint inhibitor (ICI) therapy in patients with lung adenocarcinoma. Understanding the nuances o…
View article: Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations
Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 Mutations Open
Rationale Hyper IgE syndrome (STAT3-HIES), also known as Job’s syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and infl…