Zhipeng Fan
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View article: Myricetin Suppresses Inflammatory Th17 Polarization to Mitigate Alzheimer's Disease Pathogenesis
Myricetin Suppresses Inflammatory Th17 Polarization to Mitigate Alzheimer's Disease Pathogenesis Open
Aims This study aimed to investigate the therapeutic potential of myricetin, a natural flavonoid, in Alzheimer's disease (AD) by targeting Th17 cell‐mediated neuroinflammation through inhibition of the transcription factor RORγt. Methods V…
View article: Levo‐Tryptophan Promotes Osteogenesis Through Calcium‐Sensing Receptor
Levo‐Tryptophan Promotes Osteogenesis Through Calcium‐Sensing Receptor Open
Previous studies reported the pro‐osteogenic ability of L‐Tryptophan (L‐Trp) and Calcium‐Sensing RCeceptor (CaSR) respectively. Recent researchers found L‐Trp could activate CaSR. Therefore, this study investigated the osteogenic mechanism…
View article: LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3
LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3 Open
In summary, HOXC8 negatively regulates LINC01013 to inhibit osteogenic differentiation of JBMMSCs under BP conditions. We also further clarified that LINC01013 binding to ILF3 affects ILF3 nuclear localization to regulate JBMMSCs osteogeni…
View article: Correction: Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
Correction: Dietary nitrate supplementation prevents radiotherapy-induced xerostomia Open
View article: The spatial correlation network evolution and influencing factors of industrial carbon emission efficiency in China
The spatial correlation network evolution and influencing factors of industrial carbon emission efficiency in China Open
Clarifying the spatial correlation network (SCN) evolution characteristics and influencing factors of industrial carbon emission efficiency (ICEE) is of great significance for improving ICEE, achieving the ''dual carbon policy'' goals, and…
View article: Betaine Alleviates Bisphosphonate-Related Osteonecrosis of the Jaw by Rescuing BMSCs Function in an m6A-METTL3-Dependent Manner
Betaine Alleviates Bisphosphonate-Related Osteonecrosis of the Jaw by Rescuing BMSCs Function in an m6A-METTL3-Dependent Manner Open
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the side effects of bisphosphonate (BP) administration. Despite some preventive measures having been suggested, a definitive and effective treatment strategy for BRONJ remai…
View article: Hierarchical Organization of Bilateral Prefrontal‐Basal Ganglia Circuits for Response Inhibition Control
Hierarchical Organization of Bilateral Prefrontal‐Basal Ganglia Circuits for Response Inhibition Control Open
Response inhibition control is primarily supported by the right inferior frontal gyrus (IFG) and the prefrontal‐basal ganglia network, though the mechanisms behind right lateralization and regional interplay remain unclear. In this fMRI st…
View article: EZH2, <i>via</i> an association with KDM2B, modulates osteogenic differentiation of root apical papillary stem cells
EZH2, <i>via</i> an association with KDM2B, modulates osteogenic differentiation of root apical papillary stem cells Open
BACKGROUND Stem cells from apical papilla (SCAPs) represent promising candidates for bone regenerative therapies due to their osteogenic potential. However, enhancing their differentiation capacity remains a critical challenge. Enhancer of…
View article: Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells
Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells Open
Dental mesenchymal stem cells (DMSCs) are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential an…
View article: m6A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla
m6A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla Open
Epigenetic modifications play a crucial role in regulating stem cell differentiation. Among these, N6-methyladenosine (m6A) modification significantly impacts mRNA stability and translation. However, its role in dental stem cell differenti…
View article: WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells
WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells Open
BACKGROUND Periodontitis is an inflammatory disease caused by the host’s immune response and various interactions between pathogens, which lead to the loss of connective tissue and bone. In recent years, mesenchymal stem cell (SC) transpla…
View article: Correction: Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine
Correction: Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine Open
View article: B-cell signatures characterize the immune landscape and predict LUAD prognosis via the integration of scRNA-seq and bulk RNA-seq
B-cell signatures characterize the immune landscape and predict LUAD prognosis via the integration of scRNA-seq and bulk RNA-seq Open
Lung adenocarcinoma (LUAD) is the most common type of lung cancer, accounting for approximately 35-40% of lung cancers, and the overall survival time of patients with LUAD is still very poor. B cells are important effector cells of adaptiv…
View article: Circ_0000190 inhibits the progression of triple negative breast cancer by regulating miR-301a/MEOX2 pathway
Circ_0000190 inhibits the progression of triple negative breast cancer by regulating miR-301a/MEOX2 pathway Open
Circular RNA (circRNA) and microRNA (miRNA) play critical roles in regulating proliferation, apoptosis, and invasion in triple-negative breast cancer (TNBC) cells. To investigate their functional significance, we employed quantitative real…
View article: Prediction of Energy Consumption and Carbon Emission in Yunnan Province Based on LEAP Modeling
Prediction of Energy Consumption and Carbon Emission in Yunnan Province Based on LEAP Modeling Open
View article: LncRNA NR_045147 modulates osteogenic differentiation and migration in PDLSCs via ITGB3BP degradation and mitochondrial dysfunction
LncRNA NR_045147 modulates osteogenic differentiation and migration in PDLSCs via ITGB3BP degradation and mitochondrial dysfunction Open
Periodontitis is an inflammation of the alveolar bone and soft tissue surrounding the teeth. Although mesenchymal stem cells (MSCs) have been implicated in periodontal regeneration, the mechanisms by which they promote osteogenesis remain …
View article: A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes Open
Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge. Neut…
View article: <scp>KDM2B</scp> and its peptides promote the stem cells from apical papilla mediated nerve injury repair in rats by intervening <scp>EZH2</scp> function
<span>KDM2B</span> and its peptides promote the stem cells from apical papilla mediated nerve injury repair in rats by intervening <span>EZH2</span> function Open
How to improve the neurogenic potential of mesenchymal stem cells (MSCs) and develop biological agent based on the underlying epigenetic mechanism remains a challenge. Here, we investigated the effect of histone demethylase Lysine (K)‐spec…
View article: Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress Open
Radiation-induced salivary gland injury (RISGI) is a common complication of radiotherapy in patients with head and neck cancer. Intragland expression of the Sonic Hedgehog (Shh) gene may partially rescue irradiation (IR)-induced hyposaliva…
View article: STL Inhibited Angiogenesis of DPSCs Through Depressing Mitochondrial Respiration by Enhancing RNF217
STL Inhibited Angiogenesis of DPSCs Through Depressing Mitochondrial Respiration by Enhancing RNF217 Open
Angiogenesis is the determining factor during dental pulp regeneration. Six‐twelve leukemia (STL) is identified as a key regulatory factor on the biological function of dental pulp stem cells (DPSCs) under hypoxic conditions, but its effec…
View article: METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs Open
View article: Featured Cover
Featured Cover Open
The cover image is based on the Review New insights into the interaction between m6A modification and lncRNA in cancer drug resistance by Yizhou Jin and Zhipeng Fan https://doi.org/10.1111/cpr.13578 . image
View article: <scp>miR615</scp>‐3p inhibited <scp>FBLN1</scp> and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m<sup>6</sup>A‐miRNA interaction manner
<span>miR615</span>‐3p inhibited <span>FBLN1</span> and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m<sup>6</sup>A‐miRNA interaction manner Open
To investigate the role and mechanism of FBLN1 in the osteogenic differentiation and bone regeneration by using umbilical cord mesenchymal stem cells (WJCMSCs). We found that FBLN1 promoted osteogenic differentiation of WJCMSCs and WJCMSC‐…
View article: The comparative study of urban ecosystem health change in Asian and African coastal cities—Changle in China and Suez in Egypt
The comparative study of urban ecosystem health change in Asian and African coastal cities—Changle in China and Suez in Egypt Open
Urban Ecosystem Health (UEH) refers to the integrated capacity of urban ecosystems to both maintain and regenerate themselves and to provide ecological services for urban populations. Rapid global urbanization over the last two decades has…
View article: Development and validation of nomograms to predict survival and recurrence following hepatectomy for intermediate/advanced (BCLC stage B/C) hepatocellular carcinoma
Development and validation of nomograms to predict survival and recurrence following hepatectomy for intermediate/advanced (BCLC stage B/C) hepatocellular carcinoma Open
View article: Laparoscopic approach reduces the incidence of postoperative pulmonary complications after hepatectomy for hepatocellular carcinoma: a multicenter overlap propensity score-weighted analysis
Laparoscopic approach reduces the incidence of postoperative pulmonary complications after hepatectomy for hepatocellular carcinoma: a multicenter overlap propensity score-weighted analysis Open
View article: New insights into the interaction between m6A modification and lncRNA in cancer drug resistance
New insights into the interaction between m6A modification and lncRNA in cancer drug resistance Open
Drug resistance is perhaps the greatest obstacle in improving outcomes for cancer patients, leading to recurrence, progression and metastasis of various cancers. Exploring the underlying mechanism worth further study. N6‐methyladenosine (m…
View article: MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1
MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1 Open
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a challenge. Mixed lineage leukemia 1 (MLL1), an H3K4me3 methyltransferases…
View article: tRNA‐derived small RNA changes in bone marrow stem cells under hypoxia and osteogenic conduction
tRNA‐derived small RNA changes in bone marrow stem cells under hypoxia and osteogenic conduction Open
Background Tissue engineering using bone mesenchymal stem cells (BMSCs) transplantation is a promising therapeutic for bone regeneration. However, the effect of bone regeneration remains unsatisfactory due to the BMSCs' functional abnormal…
View article: KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1
KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1 Open
Stem cells from the apical papilla (SCAPs) are used to regulate the microenvironment of nerve defects. KDM6B, which functions as an H3K27me3 demethylase, is known to play a crucial role in neurogenesis. However, the mechanism by which KDM6…