Zhi Ping Xu
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View article: Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands
Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands Open
The conjugation of ligands to nanoparticle platforms for the target delivery of therapeutic agents to the tumor tissue is one of the promising anti-cancer strategies. However, conventional nanoparticle platforms are not so effective in ter…
View article: Genomics-Assisted Improvement in Blast Resistance and Low Cadmium Accumulation in an Elite Rice Variety
Genomics-Assisted Improvement in Blast Resistance and Low Cadmium Accumulation in an Elite Rice Variety Open
Xiangwanxian 13 (XWX13), an elite fragrant indica rice, is highly susceptible to rice blast and accumulates cadmium (Cd) in grain above the food safety limit in Cd-contaminated paddies, severely constraining its commercial use. Despite the…
View article: Understanding of vascular toxicity of indigo naturalis in anti-inflammation application: mendelian randomization and colocalization study
Understanding of vascular toxicity of indigo naturalis in anti-inflammation application: mendelian randomization and colocalization study Open
The Chinese herbal medicine indigo naturalis (IN) shows promising potential for treating autoimmune inflammatory diseases. However, its clinical application is limited by vascular toxicity. Using Mendelian randomization analysis, we conduc…
View article: Synergistic blockade of SHP-2 and A2AR signal pathways with targeted nanoparticles restores anti-tumor immunity of CD8+ T cells
Synergistic blockade of SHP-2 and A2AR signal pathways with targeted nanoparticles restores anti-tumor immunity of CD8+ T cells Open
Anti-PD-1/PD-L1-based immune checkpoint blockade targeting T cell immunoregulatory proteins has revolutionized cancer treatment. However, only a limited number of patients benefit from this therapy due to the therapeutic resistance and inh…
View article: Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation
Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation Open
Drug‐induced acute liver failure (ALF) is characterized by rapid hepatocyte necrosis caused by oxidative stress and Kupffer cell (KC)‐mediated inflammation, with limited therapeutic options due to narrow treatment windows. To target this c…
View article: Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery
Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery Open
It is reported that poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs) coated with chitosan and its derivatives, such as glycol chitosan (GC), can enhance the targeted uptake of PLGA NPs by intestinal epithelial cells. However, the o…
View article: Genomics-Assisted Improvement on Blast Resistance and Low Cadmium Accumulation in An Elite Rice Variety ‘Xiangwanxian 13’
Genomics-Assisted Improvement on Blast Resistance and Low Cadmium Accumulation in An Elite Rice Variety ‘Xiangwanxian 13’ Open
Xiangwanxian 13 (XWX13), a fragrant indica rice variety with high yield and good grain quality, is generally welcomed by farmers in China. However, the fact that XWX13 is highly susceptible to rice blast and its high grain cadmium (Cd) acc…
View article: Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy
Self‐Oxygenating PROTAC Microneedle for Spatiotemporally‐Confined Protein Degradation and Enhanced Glioblastoma Therapy Open
Glioblastoma (GBM) is the most aggressive subtype of primary brain tumors, which marginally respond to standard chemotherapy due to the blood‐brain barrier (BBB) and the low tumor specificity of the therapeutics. Herein, a double‐layered m…
View article: Neural Network Modeling of Microstructure Complexity Using Digital Libraries
Neural Network Modeling of Microstructure Complexity Using Digital Libraries Open
Microstructure evolution in matter is often modeled numerically using field or level-set solvers, mirroring the dual representation of spatiotemporal complexity in terms of pixel or voxel data, and geometrical forms in vector graphics. Mot…
View article: pH of Microenvironment Directly Modulates the Phenotype and Function of Cancer-Associated Fibroblasts
pH of Microenvironment Directly Modulates the Phenotype and Function of Cancer-Associated Fibroblasts Open
Cancer-associated fibroblasts within the tumor microenvironment have been studied extensively, including their differential roles in promoting cancer growth and metastasis, promoting an immune suppressive microenvironment, and reshaping th…
View article: Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy
Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy Open
T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by the loss of tumor surface antigens and inactivation in acidic tumor microenvironment (TME). Herein, we developed a bifunctional immu…
View article: Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study
Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study Open
Background: Indigo naturalis (IN), a traditional Chinese herbal medicine, shows promising potential for treating autoimmune inflammatory diseases. However, its clinical translation and application are being limited by concerns regarding va…
View article: MS4A15 gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma
MS4A15 gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma Open
Overall, MS4A15 emerged as a promising prognostic biomarker for LUAD and could serve as a potential target for the development of novel therapeutic interventions.
View article: Investigations into Capillary Forces and Capillary Rise in a Three-Finger Microgripper and a Plate: Numerical Simulations and Experimental Validation
Investigations into Capillary Forces and Capillary Rise in a Three-Finger Microgripper and a Plate: Numerical Simulations and Experimental Validation Open
The assembly and position adjustment of micro-components have wide applications in micro-electromechanical systems, wafer packaging and biomedicine. However, current single-finger microgrippers only allow for the pickup and release of micr…
View article: Bridging the Resource Gap: Deploying Advanced Imitation Learning Models onto Affordable Embedded Platforms
Bridging the Resource Gap: Deploying Advanced Imitation Learning Models onto Affordable Embedded Platforms Open
Advanced imitation learning with structures like the transformer is increasingly demonstrating its advantages in robotics. However, deploying these large-scale models on embedded platforms remains a major challenge. In this paper, we propo…
View article: Understanding of Polydopamine Formulation for Oral Therapeutic Delivery in Ulcerative Colitis Treatment
Understanding of Polydopamine Formulation for Oral Therapeutic Delivery in Ulcerative Colitis Treatment Open
Oral therapeutic delivery remains challenged by gastrointestinal tract (GI) barriers, which hinders the successful transition of therapeutic candidates into clinical treatments. Polydopamine (PDA), with its versatile ability to overcome GI…
View article: Responsive Theranostic Nanoprobe for Ratiometric Photoacoustic Monitoring of Hypochlorous Acid‐Mediated Inflammation in Cancer Photothermal Therapy
Responsive Theranostic Nanoprobe for Ratiometric Photoacoustic Monitoring of Hypochlorous Acid‐Mediated Inflammation in Cancer Photothermal Therapy Open
Cancer detection and inflammation monitoring during photothermal therapy (PTT) enable timely cancer intervention and precise inflammation control, advancing to address inflammation‐related tumor recurrence and metastasis associated with PT…
View article: Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death
Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death Open
Encapsulation of drugs into nanocarriers is proven to be highly promising approach in reducing drug toxicity and enhancing therapeutic efficacy. However, controlling the loading efficiency and capacity, and release of therapeutics at speci…
View article: Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs
Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs Open
Aluminum adjuvants (Alum), approved by the US Food and Drug Administration, have been extensively used in vaccines containing recombinant antigens, subunits of pathogens, or toxins for almost a century. While Alums typically elicit strong …
View article: Fostering rehydration and facilitating bioactive release through cellulose-assisted leaf surface treatment
Fostering rehydration and facilitating bioactive release through cellulose-assisted leaf surface treatment Open
Glyphosate is a widely used herbicide in weed control and crop protection. However, its low bioavailability on leaf surfaces of weeds led to excessive use of glyphosate, inducing herbicide-resistant development and major sustainable agricu…
View article: Atomically-precise synthesis and simultaneous integration of 2D transition metal dichalcogenides enabled by nano-confinement
Atomically-precise synthesis and simultaneous integration of 2D transition metal dichalcogenides enabled by nano-confinement Open
Two-dimensional (2D) materials, such as graphene and transition metal dichalcogenides (TMDs), possess intriguing properties imparted by their unique atomic-scale structures, and greatly enriched by their various van der Waals (vdW) homo-/h…
View article: NGS panel enhance precise diagnosis of myeloid neoplasms under WHO-HAEM5 and International Consensus Classification: An observational study
NGS panel enhance precise diagnosis of myeloid neoplasms under WHO-HAEM5 and International Consensus Classification: An observational study Open
This study aimed to assess hematological diseases next-generation sequencing (NGS) panel enhances the diagnosis and classification of myeloid neoplasms (MN) using the 5th edition of the WHO Classification of Hematolymphoid Tumors (WHO-HAEM…