Zheng‐Yi Zhou
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View article: Barriers to Hospice and Palliative Care in Developing Countries and its Moral Implications
Barriers to Hospice and Palliative Care in Developing Countries and its Moral Implications Open
While palliative and hospice care were generally well established in most developed countries, with many centres and professionals providing suitable care and treatments to patients in different situations, this type of treatment to patien…
View article: Acute Lead Exposure Weakens Myocardial Contractile Function and the Therapeutic Effect of Alpha Lipoic Acid
Acute Lead Exposure Weakens Myocardial Contractile Function and the Therapeutic Effect of Alpha Lipoic Acid Open
This study comprehensively utilized toad hearts and myocardial cell models to explore the effects of acute lead exposure on myocardial contractile function and the therapeutic effect of alpha lipoic acid (ALA). The results showed that lead…
View article: Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention
Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention Open
USP44-SENP2 axis is a pivotal factor in the progression of ESCC, and provides potential therapeutic targets for ESCC patients.
View article: Generating optimal Gravitational-Wave template banks with metric-preserving autoencoders
Generating optimal Gravitational-Wave template banks with metric-preserving autoencoders Open
Matched filtering for signal detection in noisy data requires template banks that capture variation in signal waveforms while minimizing computational cost. Dimensionality reduction of signal waveforms can be important for building efficie…
View article: Dynamic mechanical properties of lunar regolith based geopolymer: Coupled effects of composition and temperature
Dynamic mechanical properties of lunar regolith based geopolymer: Coupled effects of composition and temperature Open
This study developed a high-fidelity lunar regolith simulant (GCD-2) that closely replicated the physicochemical properties of lunar samples retrieved by the Chang'e-6 mission. A lunar regolith based geopolymer (LRG) was subsequently synth…
View article: Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis
Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis Open
View article: A Multicenter Study on Unnecessary Rebiopsies in CT‐Guided Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions
A Multicenter Study on Unnecessary Rebiopsies in CT‐Guided Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions Open
Background and Objective Computed tomography‐guided percutaneous transthoracic needle biopsy of pulmonary lesions (PTNBP) is widely used for diagnosing and managing lung cancer. However, rebiopsies are often required due to insufficient sp…
View article: Real-world clinical outcomes of cabozantinib as a second-line treatment for advanced hepatocellular carcinoma: a retrospective US claims analysis
Real-world clinical outcomes of cabozantinib as a second-line treatment for advanced hepatocellular carcinoma: a retrospective US claims analysis Open
Background Cabozantinib is indicated for hepatocellular carcinoma (HCC) following first-line (1L) sorafenib, but the 1L standard has shifted to immuno-oncology (IO)-based regimens. This study evaluated real-world outcomes among patients wi…
View article: PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules Open
Stress granules (SGs) are cytoplasmic, membraneless organelles that modulate mRNA metabolism and cellular adaptation under stress, yet the mechanisms by which they regulate cancer cell survival remain unclear. Here, we identify Poly(A)-Bin…
View article: Superior diagnostic performance of Grocott methenamine silver staining in pulmonary cryptococcosis: a multicenter, large-sample cohort study
Superior diagnostic performance of Grocott methenamine silver staining in pulmonary cryptococcosis: a multicenter, large-sample cohort study Open
Introduction In the histopathological diagnosis of pulmonary fungal infections, particularly pulmonary cryptococcosis, the diagnostic performance of different staining techniques varies significantly, often confounding pathologists. This s…
View article: Cost per outcome of nivolumab + relatlimab vs BRAF + MEK inhibitor combinations for first-line treatment of <i>BRAF</i>-mutant advanced melanoma
Cost per outcome of nivolumab + relatlimab vs BRAF + MEK inhibitor combinations for first-line treatment of <i>BRAF</i>-mutant advanced melanoma Open
NIVO + RELA showed improved LYs and PFLYs at lower cost than all 3 BRAFi/MEKi comparators over 5 years. These results support the economic value of NIVO + RELA for patients with previously untreated, BRAF-mutated, unresectable or me…
View article: Longitudinal associations between Big Five personality and insomnia: evidence based on a 4-year perspective cohort study among community residents
Longitudinal associations between Big Five personality and insomnia: evidence based on a 4-year perspective cohort study among community residents Open
Introduction While the association between personality traits and insomnia has been confirmed, the longitudinal relationship between them remains unclear. Methods This is a 4-year longitudinal cohort study conducted among rural community r…
View article: Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma
Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma Open
Clinical data have shown that Serine/Threonine Kinase 11 (STK11) mutation may be associated with an immunosuppressive tumor microenvironment (ITEM) and poor prognosis and failure of anti-PD-1 (αPD1) treatment in non-small cell lung cancer …
View article: Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway
Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway Open
View article: The humanistic burden of focal segmental glomerulosclerosis on patients and care-partners in the United States
The humanistic burden of focal segmental glomerulosclerosis on patients and care-partners in the United States Open
View article: Global Trends in Adolescent Health Inequalities and Their Social Determinants: A Bibliometric Analysis Using CiteSpace
Global Trends in Adolescent Health Inequalities and Their Social Determinants: A Bibliometric Analysis Using CiteSpace Open
Objective: To conduct a scoping review of the global trends of adolescent health inequities and their social determinants from 2000 to 2024 and establish an evidence base for developing targeted intervention strategies. Methods: Guided by …
View article: Improved Prediction of Bacterial Type VI Secretion Effector Proteins Using an Integrated Convolutional Neural Network Model Combining N-terminal Signal Sequences, Evolutionary Information and Pre-Trained Protein Language Features
Improved Prediction of Bacterial Type VI Secretion Effector Proteins Using an Integrated Convolutional Neural Network Model Combining N-terminal Signal Sequences, Evolutionary Information and Pre-Trained Protein Language Features Open
Type VI secretion system effectors (T6SEs) are crucial for bacterial pathogenicity, making their accurate identification essential for understanding bacterial virulence mechanisms. This study analyzed the differences in amino acid composit…
View article: Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer
Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer Open
View article: Berberine Synergistically with Wogonin Improved Adipose Inflammation and Insulin Resistance Associated with Obesity Through Hif-Α Axis
Berberine Synergistically with Wogonin Improved Adipose Inflammation and Insulin Resistance Associated with Obesity Through Hif-Α Axis Open
View article: Metabolic and Nutritional Variation in Tomato Varieties Reveals a Trade-Off between Fruit Size and Quality Traits
Metabolic and Nutritional Variation in Tomato Varieties Reveals a Trade-Off between Fruit Size and Quality Traits Open
View article: A Nomogram Integrating M2 Macrophages and Extracellular Matrix Components Outperforms Tnm Classification in Pulmonary Sarcomatoid Carcinoma Prognosis: A Two-Center Retrospective Study
A Nomogram Integrating M2 Macrophages and Extracellular Matrix Components Outperforms Tnm Classification in Pulmonary Sarcomatoid Carcinoma Prognosis: A Two-Center Retrospective Study Open
View article: Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy
Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy Open
These results provide preliminary evidence indicating that BMS-T7 may have the potential to deliver drugs to breast cancer cells via active targeting and hold great promise in cancer immunotherapy drug delivery applications.
View article: Dynamic Mechanical Properties of Lunar Regolith Based Geopolymer: Coupled Effects of Composition and Temperature
Dynamic Mechanical Properties of Lunar Regolith Based Geopolymer: Coupled Effects of Composition and Temperature Open
View article: Epidemiology and burden of focal segmental glomerulosclerosis among United States Veterans: An analysis of Veteran’s Affairs data
Epidemiology and burden of focal segmental glomerulosclerosis among United States Veterans: An analysis of Veteran’s Affairs data Open
Introduction Focal segmental glomerulosclerosis (FSGS) is a rare glomerular disease that can lead to reduced kidney function and kidney failure (KF). The objective of this study was to describe the epidemiology, characteristics, clinical o…
View article: The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States
The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States Open
View article: The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States
The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States Open
US adults with IgAN and their care partners experience impairments to mental and physical HRQoL and heightened levels of depression and anxiety, underscoring the need for effective IgAN therapies and care-partner support.
View article: Proteomic Profiling Identifies Upregulation of Aurora Kinases Causing Resistance to Taxane-type Chemotherapy in Triple Negative Breast Cancer
Proteomic Profiling Identifies Upregulation of Aurora Kinases Causing Resistance to Taxane-type Chemotherapy in Triple Negative Breast Cancer Open
Nowadays, chemotherapy and immunotherapy remain the major treatment strategies for Triple-Negative Breast Cancer (TNBC). Identifying biomarkers to pre-select and subclassify TNBC patients with distinct chemotherapy responses is essential. …
View article: Estimation of Health State Utility Values for Immunoglobulin A Nephropathy: A Time Trade-Off Analysis
Estimation of Health State Utility Values for Immunoglobulin A Nephropathy: A Time Trade-Off Analysis Open
Our results indicated that various IgAN health states are associated with impaired health status, with substantial utility decrements related to disease progression, elevated proteinuria, and nephrotic syndrome.
View article: First-Line Nivolumab Plus Relatlimab Versus Nivolumab Plus Ipilimumab in Advanced Melanoma: An Indirect Treatment Comparison Using RELATIVITY-047 and CheckMate 067 Trial Data
First-Line Nivolumab Plus Relatlimab Versus Nivolumab Plus Ipilimumab in Advanced Melanoma: An Indirect Treatment Comparison Using RELATIVITY-047 and CheckMate 067 Trial Data Open
PURPOSE Nivolumab plus relatlimab and nivolumab plus ipilimumab have been approved for advanced melanoma on the basis of the phase II/III RELATIVITY-047 and phase III CheckMate 067 trials, respectively. As no head-to-head trial comparing t…
View article: H2O2 promotes photodynamic efficacy of TMPyP4 against ovarian cancer in vitro by downregulating HIF-1α expression
H2O2 promotes photodynamic efficacy of TMPyP4 against ovarian cancer in vitro by downregulating HIF-1α expression Open
Photodynamic therapy (PDT), employing photosensitizers to induce formation of reactive oxygen species (ROS) for tumor elimination, is emerging as a promising treatment modality in oncology due to its unique benefits. However, the PDT appli…