Zhiqiang Fan
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View article: Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines
Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines Open
Animal models that are susceptible to SARS-CoV-2 infection and develop clinical signs like human COVID-19 are desired to understand viral pathogenesis and develop effective medical countermeasures. The golden Syrian hamster is important fo…
View article: Cloning of TabHLH112-2B gene and development of its functional marker associated with the number of spikelet per spike in wheat
Cloning of TabHLH112-2B gene and development of its functional marker associated with the number of spikelet per spike in wheat Open
View article: Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation
Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation Open
Reprogramming of the gamete into a developmentally competent embryo identity is a fundamental aspect of preimplantation development. One of the most important processes of this reprogramming is the transcriptional awakening during embryoni…
View article: Early developmental phenotypes in the cystic fibrosis sheep model
Early developmental phenotypes in the cystic fibrosis sheep model Open
Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs after birth, other organ systems particularly in the digestive tract are damaged b…
View article: Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling
Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling Open
Type I interferons (IFNs) initiate immune responses to viral infections. Their effects are mediated by the type I IFN receptor, IFNAR, comprised of two subunits: IFNAR1 and IFNAR2. One or both chains of the sheep IFNAR were disrupted in fe…
View article: Establishment of Bovine-Induced Pluripotent Stem Cells
Establishment of Bovine-Induced Pluripotent Stem Cells Open
Pluripotent stem cells (PSCs) have been successfully developed in many species. However, the establishment of bovine-induced pluripotent stem cells (biPSCs) has been challenging. Here we report the generation of biPSCs from bovine mesenchy…
View article: Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics
Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics Open
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator ( CFTR ) gene. The F508del and G542X are the most common mutations found in US patients, accounting for 86.4% and 4.6% of all mutat…
View article: Correction of a CFTR/G542X Mutation Using CRISPR/Cas9 Editing in Ovine-bovine Interspecies Embryos
Correction of a CFTR/G542X Mutation Using CRISPR/Cas9 Editing in Ovine-bovine Interspecies Embryos Open
Cystic fibrosis (CF) is a human genetic disease caused by mutations in the CF transmembrane conductance regulator ( CFTR ) gene. Correction of CFTR mutations at embryo stage could be a permanent solution to cure this disease. To assess the…
View article: Improvements in Gene Editing Technology Boost Its Applications in Livestock
Improvements in Gene Editing Technology Boost Its Applications in Livestock Open
Accelerated development of novel CRISPR/Cas9-based genome editing techniques provides a feasible approach to introduce a variety of precise modifications in the mammalian genome, including introduction of multiple edits simultaneously, eff…
View article: Donor-derived spermatogenesis following stem cell transplantation in sterile <i>NANOS2</i> knockout males
Donor-derived spermatogenesis following stem cell transplantation in sterile <i>NANOS2</i> knockout males Open
Significance Transfer of sperm-producing stem cells isolated from a donor male into testes of a recipient male has important applications for preserving germplasm and as a conduit for widespread dissemination of desirable genetics in lives…
View article: Assessment of microchimerism following somatic cell nuclear transfer and natural pregnancies in goats
Assessment of microchimerism following somatic cell nuclear transfer and natural pregnancies in goats Open
Microchimerism is defined as the presence of a small population of cells or DNA in 1 organism originated from a genetically different organism. It is well established that this phenomenon occurs in humans and mice as cells are exchanged be…
View article: Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system
Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system Open
View article: A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene
A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene Open
Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The major cause of limited life span in CF patients is progressive lung disease. CF models have been generated in 4 sp…
View article: Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress
Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress Open