Explanipedia

Novel screening tool for psychiatric samples with major depressive disorder: a two-centre study Open

Nian Liu, Guangdong Hou, Bin Zhao, Zhiyong Cao, Jian Qing Shi , et al. · 2025

Background Major depressive disorder (MDD) poses a significant global public health challenge. Although the Patient Health Questionnaire-9 (PHQ-9) is widely used for MDD screening, its validation in psychiatric samples is limited. Addition…

Study on the Construction and Anti-Tumor Effect of aPDL1/aMUC1 Double Antibody Modification of Doxorubicin Liposome Open

Shouzhen Zhao, Cuiling Xuan, Wenbin Diao, Ran Bai, Fei Wu , et al. · 2025

In recent years, the primary treatments for cancer have included chemotherapy, radiotherapy, and surgery. However, challenges such as poor prognosis, high recurrence rates, low survival rates, and diminished quality of life persist in canc…

YKL-40 inhibits melanoma progression and metastasis by inducing immune cell infiltration in a mouse model Open

Hailong Zhang, Xiangyu Zhao, Mengqi Shi, Yuqi Han, Kun Ping Lu , et al. · 2025

The value of ITGA and ITGB superfamily genes as biomarkers for the early diagnosis and prognosis of gliomas: A retrospective observational study based on the GEPIA and CGGA databases Open

Ben Yang, Yuqi Han, Mengqi Shi, Kun Lü, Yi Wang , et al. · 2025

hsa‑miR‑1‑3p and hsa‑miR‑361‑3p as potential biomarkers for onychomycosis: A pilot study Open

Meng Li, Qing Cai, Huidong Zhang, Zhiqin Gao, Lianjuan Yang · 2024

Non-coding small molecule RNAs are associated with a variety of diseases, including infectious diseases. However, small RNA-related studies in onychomycosis have not been reported. The aim of the present study was to conduct an initial inv…

Improved efficacy of cisplatin delivery by peanut agglutinin‑modified liposomes in non‑small cell lung cancer Open

Ben Yang, Rongguan Kou, Hui Wang, Anping Wang, Lili Wang , et al. · 2024

Globally, non‑small cell lung cancer (NSCLC) is a significant threat to human health, and constitutes >80% of lung cancer cases. Cisplatin (CDDP), a commonly used drug in clinical treatment, has been the focus of research aiming to mitigat…

Enhancing the Inhibition of Breast Cancer Growth Through Synergistic Modulation of the Tumor Microenvironment Using Combined Nano-Delivery Systems Open

Jingliang Wu, Lu Qiao, Jialin Zhao, Wendi Wu, Zhihua Wang , et al. · 2024

In brief, this combination therapy based on Dox@CLGs and Ber/Ru486@CLPs could effectively inhibit tumor development, which provides a promising approach for the treatment of breast cancer.

YKL-40 inhibits melanoma progression and metastasis by inducing immune cell infiltration in a mouse model Open

Hailong Zhang, Xiangyu Zhao, Hong Fu, Mengqi Shi, Yuqi Han , et al. · 2024

Background YKL-40, a glycoprotein implicated in the pathophysiology of various solid tumors, exhibits a paradoxical expression profile in melanoma, characterized by reduced levels in tumor tissues relative to normal cutaneous tissues. Inte…

Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats <i>via</i> glucagon-like peptide 1-mediated Nrf2/HO-1 signaling Open

Huai-Jie Wang, Libin Zhang, Si-Peng Sun, Qingtao Yan, Zhiqin Gao , et al. · 2024

BACKGROUND Type 2 diabetes mellitus (T2DM) is often accompanied by impaired glucose utilization in the brain, leading to oxidative stress, neuronal cell injury and infla-mmation. Previous studies have shown that duodenal jejunal bypass (DJ…

Duodenal–Jejunal Bypass Restores Sweet Taste Receptor‐Mediated Glucose Sensing and Absorption in Diabetic Rats Open

Sipeng Sun, Anping Wang, Rongguan Kou, Hantao Xue, Xiangyu Zhao , et al. · 2024

Aim: The aim of the study is to identify the regulatory role of intestinal sweet taste receptors (STRs) and glucose transporters (SGLT1, GLUT2) and gut peptide secretion in duodenal–jejunal bypass (DJB)–ameliorated glycemic control in Type…

MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma Open

Qian Zhuliang, Lifeng Xie, Zhiqin Gao, Guowei Wang, Ming Zhan · 2023

Objective: To assess MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma. Methods: 94 patients with osteosarcoma confirmed by surgical pathology in our hospital from September 2019 to September 2021 …

DNA microarray chip assay in new use: early diagnostic value in cutaneous mycobacterial infection Open

Qian Yu, Yuanyuan Wang, Zhiqin Gao, Yang Hong, Siyu Liu , et al. · 2023

Introduction The clinical practicability of DNA microarray chip in detecting the presence of mycobacterial species/isolates directly in the skin tissues has not been evaluated, nor the efficacy of DNA microarray chip as a novel diagnostic …

Case report: Subcutaneous Mycobacterium haemophilum infection in an immunocompetent patient after lipolysis injections Open

Linan Ni, Danyang Zou, Hong Yang, Zhiqin Gao, Qian Yu , et al. · 2023

Mycobacterium haemophilum is a slow-growing, aerobic mycobacterium that acts as a pathogen in immunocompromised adult patients and immunocompetent children. There are only a few rare cases in the literature describing this species as a cau…

Functional analysis of the short splicing variant encoded by CHI3L1/YKL-40 in glioblastoma Open

Mengqi Shi, Qianyun Ge, Xinrong Wang, Wenbin Diao, Ben Yang , et al. · 2022

The glycoprotein YKL-40 has been well studied as a serum biomarker of prognosis and disease status in glioblastoma. YKL-40 is a chitinase-like protein with defective chitinase activity that plays an important role in promoting cell prolife…

Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation Open

Jingwen Tan, Qian Yu, Zhiqin Gao, Hong Yang, Qilong Chen , et al. · 2022

Dermatophytosis is the most common type of superficial fungal infection caused by dermatophytes. Occasionally, the fungus invades deep into the dermis or other tissues, causing deep dermatophytosis. Deep dermatophytosis is often associated…

Nomogram to predict malignancy in branch duct type intraductal papillary mucinous neoplasms Open

Yisheng Xu, Chunmei Xie, Zhiqin Gao, Meihua Zhang, Ming Zhan · 2022

Prediction of malignancy in branch duct (BD)-type intraductal papillary mucinous neoplasms (BD-IPMNs) is difficult. In this retrospective study, we showed the performance of imaging biomarker and biochemical biomarker in identifying the ma…

Curcumin and berberine co-loaded liposomes for anti-hepatocellular carcinoma therapy by blocking the cross-talk between hepatic stellate cells and tumor cells Open

Jingliang Wu, Cuiping Qi, Hao Wang, Qing Wang, Jingui Sun , et al. · 2022

Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment (TME). In hepatocellular carcinoma (HCC), quiescent hepatic stellate cells (HSCs) could be activated to become CAFs, which play a critical role in tum…

PNA-Modified Liposomes Improve the Delivery Efficacy of CAPIRI for the Synergistic Treatment of Colorectal Cancer Open

Wenbin Diao, Ben Yang, Sipeng Sun, Anping Wang, Rongguan Kou , et al. · 2022

Tumor-associated antigen mucin 1 (MUC1) is highly expressed in colorectal cancer and is positively correlated with advanced stage at diagnosis and poor patient outcomes. The combination of irinotecan and capecitabine is standard chemothera…

Duodenal-Jejunal Bypass Restores T1R2-Mediated Glucose Sensing and SGLT1-Regulated Glucose Absorption in Type 2 Diabetes Open

Sipeng Sun, Hantao Xue, Anping Wang, Rongguan Kou, Xiangyu Zhao , et al. · 2022

XPC Protein Improves Lung Adenocarcinoma Prognosis by Inhibiting Lung Cancer Cell Stemness Open

Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang , et al. · 2021

Objective: Xeroderma Pigmentosum Complementation Group C (XPC) is a protein involving in nucleotide excision repair (NER). XPC also plays an important role in the lung cancer occurrence with the mechanism remian unclear up to date. Studies…

Preparation of docetaxel‑loaded, glycyrrhetinic acid‑modified nanoparticles and their liver‑targeting and antitumor activity Open

Hantao Xue, Liya Qin, Longxiang Zhang, Xiaocheng Li, Fei Wu , et al. · 2021

Liver cancer is one of the most common malignancies worldwide and poses a serious threat to human health. The most important treatment method, liver cancer chemotherapy, is limited due to its high toxicity and poor specificity. Targeted dr…

Combined anti-hepatocellular carcinoma therapy inhibit drug-resistance and metastasis via targeting “substance P-hepatic stellate cells-hepatocellular carcinoma” axis Open

Zhipeng Li, Fangqing Wang, Yanying Li, Xiaoxue Wang, Lu Qiao , et al. · 2021

Peripheral nerves have emerged as the important components in tumor microenvironment (TME), which could activate hepatic stellate cells (HSCs) by secreting substance P (SP), leading to hepatocellular carcinoma (HCC) invasion and metastasis…

PEGylated Graphene Oxide Carried OH-CATH30 to Accelerate the Healing of Infected Skin Wounds Open

Di Mei, Xiaolong Guo, Yirong Wang, Xiaofei Huang, Li Guo , et al. · 2021

The PGO-OH30 drug-delivery system had good biocompatibility and excellent drug-delivery ability, indicating its good therapeutic effect on a skin wound-infection model.

Dual-Ligand-Modified Liposomes Co-Loaded with Anti-Angiogenic and Chemotherapeutic Drugs for Inhibiting Tumor Angiogenesis and Metastasis Open

Fangqing Wang, Yanying Li, Hong Jiang, Chenglei Li, Zhaohuan Li , et al. · 2021

CUCA/GA&Gal-Lip hold great potentials in hepatoma-targeting delivery of antitumor drugs and can achieve anti-angiogenic and anti-metastatic effects by simultaneously blocking VEGF/VEGFR2 signal pathway, therefore exhibiting superior anti-h…

EGFR TKIs Combinding the inhibition of RAS-ERK signaling in NSCLC Treatment Open

Weiyu Wang, Jian Li, Shengyao Ma, Hanyue Li, Zhiqin Gao , et al. · 2021

Epidermal growth factor receptor (EGFR) mutations and EGFR overexpression have become the key factor to the occurrence of non-small cell lung cancer (NSCLC).EGFR tyrosine-protein kinase inhibitors (EGRR-Tyrosine Kinase Inhibitors, EGFR-TKI…

Enhanced targeted delivery of adenine to hepatocellular carcinoma using glycyrrhetinic acid-functionalized nanoparticles in vivo and in vitro Open

Fei Wu, Hantao Xue, Xiaocheng Li, Wenbin Diao, Bin Jiang , et al. · 2020

Hepatocellular carcinoma (HCC), a common malignancy in China and globally, is primarily treated through surgical resection and liver transplantation, with chemotherapy as a significant synergistic option. Adenine (Ade), a nucleobase, exhib…

Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia Open

Qinghua Li, Yangyang Han, Peng Xu, Lingxuan Yin, Yanru Si , et al. · 2020

Preeclampsia (PE) is a life-threatening disorder of human pregnancy affecting 5–8% of all pregnancies. Currently, PE remains an elusive complicated and heterogenous medical condition with no early marker or symptoms is recognized for this …

Mechanical Changes and Microfilament Reorganization Involved in Microcystin-LR-Promoted Cell Invasion in DU145 and WPMY Cells Open

Qiang Zhang, Guihua Wang, Yongfang Xie, Zhiqin Gao, Zumu Liang , et al. · 2020

Microcystin-leucine arginine (MC-LR) is a potent tumor initiator that can induce malignant cell transformation. Cellular mechanical characteristics are pivotal parameters that are closely related to cell invasion. The aim of this study is …

Liver-Targeting and pH-Sensitive Sulfated Hyaluronic Acid Mixed Micelles for Hepatoma Therapy Open

Zhipeng Li, Guixiang Tian, Hong Jiang, Ruiyan Pan, Bo Lian , et al. · 2019

The sHA-DOX/HA-GA mixed micelles could be a potential drug delivery system for anti-hepatoma therapy.

Exendin-4 improves glucose metabolism in insulin-resistant cells by upregulating the phosphorylative AMPK Open

Jian Li, Dai Gong, Meihua Qu, Han Su, Zhiqin Gao , et al. · 2019

Glucagon-like peptide-1 (GLP-1) is a peptide with multiple functions in regulating blood glucose with the mechnism still not throughly understand. AMP-activated protein kinase (AMPK) plays an important role in glucose and energy homeostasi…

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