Zhirui Li
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View article: Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas
Correlation and prognosis analysis of human papillomavirus infection and P16 expression in oral and oropharyngeal squamous cell carcinomas Open
The incidence of HPV-related oral squamous cell carcinomas (OSCC)and oropharyngeal squamous cell carcinomas (OPSCC) has increased significantly in recent years, but the role of HPV and P16 in OSCC and OPSCC remains controversial. Here, we …
View article: Blood Pressure Fluctuation Pattern Associated with 90‐Day Ischemic Stroke and Transient Ischemic Attack After Total Knee Arthroplasty—A Retrospective Study
Blood Pressure Fluctuation Pattern Associated with 90‐Day Ischemic Stroke and Transient Ischemic Attack After Total Knee Arthroplasty—A Retrospective Study Open
Objective Blood pressure (BP) fluctuation has been demonstrated to be closely associated with stroke. However, at present, no attention is paid to the BP fluctuation following total knee arthroplasty (TKA). The aim of this study is to inve…
View article: Comparison of the effects of negative pressure wound therapy and negative pressure wound therapy with instillation on wound healing in a porcine model
Comparison of the effects of negative pressure wound therapy and negative pressure wound therapy with instillation on wound healing in a porcine model Open
Background Negative pressure wound therapy with instillation (NPWTi) is a novel method based on standard negative pressure wound therapy (NPWT). This study aimed to compare the effects of standard NPWT and NPWTi on bioburden and wound heal…
View article: Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis
Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis Open
Background Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients. Senescence is deeply involved in the pathogenesis of osteoarthritis. Metformin is widely used as the first-line drug for Type 2 diabet…
View article: Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta‐analysis of randomised controlled trials
Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta‐analysis of randomised controlled trials Open
Negative pressure wound therapy (NPWT) with or without instillation has been extensively applied for patients with multiple wound types. Whether NPWT with instillation is superior to NPWT alone is not known. This study aims to compare the …
View article: Associations between constipation, overeating, and depression: A survey of Chinese oldest-old and centenarians
Associations between constipation, overeating, and depression: A survey of Chinese oldest-old and centenarians Open
View article: A Novel Anatomical Locking Guide Plate for Treating Acetabular Transverse Posterior Wall Fracture: A Finite Element Analysis Study
A Novel Anatomical Locking Guide Plate for Treating Acetabular Transverse Posterior Wall Fracture: A Finite Element Analysis Study Open
Objective To improve the treatment of the acetabular transverse posterior wall fracture (ATPWF), a novel anatomical locking guidance plate (NALGP) was designed and compared with traditional fixations using finite element analysis. Methods …
View article: Calcaneal fracture maps and their determinants
Calcaneal fracture maps and their determinants Open
Background Calcaneal fractures are associated with numerous complications and a poor prognosis with significant long-term quality-of-life issues, regardless of treatment. Therefore, in-depth research into the underlying mechanism of calcan…
View article: Establishment and characterization of an induced pluripotent stem cell line CPGHi004-A from peripheral blood mononuclear cells of a healthy adult
Establishment and characterization of an induced pluripotent stem cell line CPGHi004-A from peripheral blood mononuclear cells of a healthy adult Open
Induced pluripotent stem cells (iPSCs) are regarded as ideal cell sources of neural stem cells for the treatment of spinal cord injury (SCI). To minimize the damages to donors, we sought to generate iPSC lines from peripheral blood mononuc…
View article: 3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice
3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice Open
View article: Finite Element Analysis of a Novel Anatomical Locking Guide Plate for Anterior Column and Posterior Hemi-Transverse Acetabular Fractures
Finite Element Analysis of a Novel Anatomical Locking Guide Plate for Anterior Column and Posterior Hemi-Transverse Acetabular Fractures Open
Purpose The increasing worldwide prevalence of anterior column-posterior hemi-transverse fracture (ACPHTF) brings formidable challenges to orthopaedic surgeons. Our newly-designed locking plate had previously demonstrated promising effects…
View article: Calcaneal Fracture Maps And Their Determinants
Calcaneal Fracture Maps And Their Determinants Open
Background: Calcaneal fractures are associated with numerous complications and a poor prognosis with significant long-term quality-of-life issues, regardless of treatment. Therefore, in-depth research into the underlying mechanism of calca…
View article: The Effect of Passive Smoking on Early Clinical Outcomes After Total Knee Arthroplasty Among Female Patients
The Effect of Passive Smoking on Early Clinical Outcomes After Total Knee Arthroplasty Among Female Patients Open
Passive smoking negatively affects TKA among female patients. It may trigger poor pain and functional outcomes, aggravate depression and anxiety, and deteriorate quality of life after discharge from hospital. Avoiding exposure to smoking e…
View article: Symptom cluster patterns based on text clustering method of COVID-19 and its population characteristics in Sichuan province, China
Symptom cluster patterns based on text clustering method of COVID-19 and its population characteristics in Sichuan province, China Open
Background: Evidence of the aggregation of COVID-19 symptoms was still limited. Exploration of likely cluster patterns of symptoms may be helpful. Methods: This study enrolled a total of 1067 COVID-19 cases. Symptom cluster patterns were e…
View article: A Novel Anatomical Locking Guide Plate in Treating Acetabular Transverse Posterior Wall Fracture: A Finite Element Analysis Study
A Novel Anatomical Locking Guide Plate in Treating Acetabular Transverse Posterior Wall Fracture: A Finite Element Analysis Study Open
Background: The acetabular transverse posterior wall fracture (ATPWF) is a classic type of associated acetabular fracture with an increasing prevalence worldwide. The optimal treatment for this complex facture remains a formidable challeng…
View article: Biomechanical comparison of medial sustainable nail and proximal femoral nail antirotation in the treatment of an unstable intertrochanteric fracture
Biomechanical comparison of medial sustainable nail and proximal femoral nail antirotation in the treatment of an unstable intertrochanteric fracture Open
Aims Restoration of proximal medial femoral support is the keystone in the treatment of intertrochanteric fractures. None of the available implants are effective in constructing the medial femoral support. Medial sustainable nail (MSN-II) …
View article: Simulation analysis of impact damage to the bone tissue surrounding a dental implant
Simulation analysis of impact damage to the bone tissue surrounding a dental implant Open
View article: Adaptive expression of biofilm regulators and adhesion factors of Staphylococcus aureus during acute wound infection under the treatment of negative pressure wound therapy in vivo
Adaptive expression of biofilm regulators and adhesion factors of Staphylococcus aureus during acute wound infection under the treatment of negative pressure wound therapy in vivo Open
Negative pressure wound therapy (NPWT) is gaining acceptance as a physical therapy for a wide variety of infected wounds. To gain insight into the response of bacteria to NPWT in vivo, the adaptive expression of biofilm regulators a…
View article: Three-dimensional mapping of intertrochanteric fracture lines
Three-dimensional mapping of intertrochanteric fracture lines Open
The fracture patterns observed in the present study might be used to describe morphologic characteristics and aid with management strategies. Further classifications or modifications that incorporate the fracture patterns identified in thi…
View article: Impact of negative‐pressure wound therapy on bacterial behaviour and bioburden in a contaminated full‐thickness wound
Impact of negative‐pressure wound therapy on bacterial behaviour and bioburden in a contaminated full‐thickness wound Open
The use of negative‐pressure wound therapy (NPWT) has displayed significant clinical benefits in the healing of infected wounds. However, the effects of NPWT on bacterial colonisation and infection of traumatic wounds has been controversia…
View article: Multiplex graph matching matched filters
Multiplex graph matching matched filters Open
We consider the problem of detecting a noisy induced multiplex template network in a larger multiplex background network. Our approach, which extends the framework of Sussman et al. (2019) to the multiplex setting, leverages a multiplex an…
View article: Establishment of fluoroscopy views and standardized procedure of percutaneous magic screw insertion for acetabulum fractures
Establishment of fluoroscopy views and standardized procedure of percutaneous magic screw insertion for acetabulum fractures Open
View article: Effect of low-intensity pulsed ultrasound on distraction osteogenesis: a systematic review and meta-analysis of randomized controlled trials
Effect of low-intensity pulsed ultrasound on distraction osteogenesis: a systematic review and meta-analysis of randomized controlled trials Open
View article: Tranexamic acid reduces intraoperative occult blood loss and tourniquet time in obese knee osteoarthritis patients undergoing total knee arthroplasty: a prospective cohort study
Tranexamic acid reduces intraoperative occult blood loss and tourniquet time in obese knee osteoarthritis patients undergoing total knee arthroplasty: a prospective cohort study Open
Tranexamic acid can reduce occult blood loss and tourniquet time in obese patients to a greater extent than in patients of normal weight. Therefore, obese knee osteoarthritis patients undergoing TKA can benefit more from tranexamic acid.
View article: Combination therapy of anabolic agents and bisphosphonates on bone mineral density in patients with osteoporosis: a meta-analysis of randomised controlled trials
Combination therapy of anabolic agents and bisphosphonates on bone mineral density in patients with osteoporosis: a meta-analysis of randomised controlled trials Open
Objective We aimed to determine whether the concomitant combination therapy of anabolic agents and bisphosphonates produces more effects on bone mineral density (BMD) than anabolic agents alone in patients with osteoporosis. Methods We sea…
View article: Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model
Negative pressure wound therapy reduces the motility of Pseudomonas aeruginosa and enhances wound healing in a rabbit ear biofilm infection model Open
View article: Parathyroid hormone analogues for fracture healing: protocol for a systematic review and meta-analysis of randomised controlled trials
Parathyroid hormone analogues for fracture healing: protocol for a systematic review and meta-analysis of randomised controlled trials Open
Introduction Fracture healing is a complex physiological process. Impaired healing will increase the need for care and cause serious complications. Thus, identifying strategies to accelerate the rate of healing, preventing delayed unions a…
View article: Negative-Pressure Wound Therapy in a<i>Pseudomonas aeruginosa</i>Infection Model
Negative-Pressure Wound Therapy in a<i>Pseudomonas aeruginosa</i>Infection Model Open
Background . Negative-pressure wound therapy (NPWT) is an effective strategy for the management of contaminated wounds, including those infected by Pseudomonas aeruginosa . We hypothesized that NPWT would reduce virulence factors as well a…
View article: Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy
Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy Open
The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and product…
View article: The effects of low-intensity pulsed ultrasound on fresh fracture
The effects of low-intensity pulsed ultrasound on fresh fracture Open
Moderate-to-high quality evidence shows that LIPUS treatment reduces the time to fracture union and improves the quality of life without affecting functional recovery and incident rate of delayed union and nonunion, suggesting that LIPUS t…