Zhivko Zhelev
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View article: Multi-spin Redox Sensor for Electron Paramagnetic Resonance Studies of Tissue Redox State <i>In Vivo</i>: Validation of Data With a Conventional Spin Probe
Multi-spin Redox Sensor for Electron Paramagnetic Resonance Studies of Tissue Redox State <i>In Vivo</i>: Validation of Data With a Conventional Spin Probe Open
Using a non-toxic nanoparticle in the chemical structure of RS as a carrier of nitroxide residues would enhance its translational relevance.
View article: Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack
Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack Open
View article: An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream
An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream Open
Lecithinized superoxide dismutase (PC-SOD) was found to have a significantly improved half-life in the bloodstream and better pharmacological effects compared with unmodified SOD. However, there is no direct evidence that parenterally admi…
View article: Generating evidence to support the role of AI in diabetic eye screening: considerations from the UK National Screening Committee
Generating evidence to support the role of AI in diabetic eye screening: considerations from the UK National Screening Committee Open
Screening for diabetic retinopathy has been shown to reduce the risk of sight loss in people with diabetes, because of early detection and treatment of sight-threatening disease. There is long-standing interest in the possibility of automa…
View article: The implementation of Safety Management Systems in healthcare: a systematic review and international comparison
The implementation of Safety Management Systems in healthcare: a systematic review and international comparison Open
Background In health care, errors could have serious consequences for patients and staff. High-risk industries, such as aviation, have improved safety by taking a systems approach, known as safety management systems. Safety management syst…
View article: How Is Extra Care Housing for Older People Defined in the UK? Observations From a Scoping Review
How Is Extra Care Housing for Older People Defined in the UK? Observations From a Scoping Review Open
Background Extra care housing is a model of housing for older people where residents live in self‐contained accommodation with flexible care and support available 24/7. Ageing populations, seen globally and in the UK, mean increasing deman…
View article: A service evaluation of the acceptability of DERM to patients and staff at three Community Diagnostic Hubs: study protocol for interviews
A service evaluation of the acceptability of DERM to patients and staff at three Community Diagnostic Hubs: study protocol for interviews Open
Background More rapid and efficient diagnosis of suspected skin cancers has been a target for improvement in the NHS for several years. DERM (Deep Ensemble for the Recognition of Melanoma) is a Class IIa UKCA-Certified Artificial Intellige…
View article: Factors influencing effective data sharing between health care and social care regarding the care of older people: a qualitative evidence synthesis
Factors influencing effective data sharing between health care and social care regarding the care of older people: a qualitative evidence synthesis Open
Background Sharing data about patients between health and social care organisations and professionals, such as details of their medication, is essential to provide co-ordinated and person-centred care. While professionals can share data in…
View article: Screening for Autism Spectrum Disorder in Young Children: Still Not Enough Evidence
Screening for Autism Spectrum Disorder in Young Children: Still Not Enough Evidence Open
Background: Early detection of autism spectrum disorder (ASD) has the potential to significantly reduce the impact of the condition, however previous reviews have found little evidence to support screening programs for ASD in young childre…
View article: Remote monitoring for long-term physical health conditions: an evidence and gap map
Remote monitoring for long-term physical health conditions: an evidence and gap map Open
Background Remote monitoring involves the measurement of an aspect of a patient’s health without that person being seen face to face. It could benefit the individual and aid the efficient provision of health services. However, remote monit…
View article: Tolerable treatment of glioblastoma with redox-cycling ‘mitocans': a comparative study in vivo
Tolerable treatment of glioblastoma with redox-cycling ‘mitocans': a comparative study in vivo Open
Objectives: The present study describes a pharmacological strategy for the treatment of glioblastoma by redoxcycling 'mitocans' such as quinone/ascorbate combination drugs, based on their tumor-selective redox-modulating effects and…
View article: Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy
Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy Open
Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling “mitocans” such as quinone/ascorbate (Q/A) redox-pairs, which makes cancer cells fragile and sensitive without adverse effects on normal cells…
View article: Test accuracy of artificial intelligence-based grading of fundus images in diabetic retinopathy screening: A systematic review
Test accuracy of artificial intelligence-based grading of fundus images in diabetic retinopathy screening: A systematic review Open
Objectives To systematically review the accuracy of artificial intelligence (AI)-based systems for grading of fundus images in diabetic retinopathy (DR) screening. Methods We searched MEDLINE, EMBASE, the Cochrane Library and the ClinicalT…
View article: Health technology assessment of diagnostic tests: a state of the art review of methods guidance from international organizations
Health technology assessment of diagnostic tests: a state of the art review of methods guidance from international organizations Open
Objectives To identify which international health technology assessment (HTA) agencies are undertaking evaluations of medical tests, summarize commonalities and differences in methodological approach, and highlight examples of good practic…
View article: Serial high-sensitivity cardiac troponin testing for the diagnosis of myocardial infarction: a scoping review
Serial high-sensitivity cardiac troponin testing for the diagnosis of myocardial infarction: a scoping review Open
Objectives We aimed to assess the diversity and practices of existing studies on several assays and algorithms for serial measurements of high-sensitivity cardiac troponin (hs-cTn) for risk stratification and the diagnosis of myocardial in…
View article: Using simulation and machine learning to maximise the benefit of intravenous thrombolysis in acute stroke in England and Wales: the SAMueL modelling and qualitative study
Using simulation and machine learning to maximise the benefit of intravenous thrombolysis in acute stroke in England and Wales: the SAMueL modelling and qualitative study Open
Background Stroke is a common cause of adult disability. Expert opinion is that about 20% of patients should receive thrombolysis to break up a clot causing the stroke. Currently, 11–12% of patients in England and Wales receive this treatm…
View article: Corrigendum to “Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation” [Redox Biol. 53 (2022) 102337]
Corrigendum to “Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation” [Redox Biol. 53 (2022) 102337] Open
View article: Health Technology Assessment of Diagnostic Tests: A state of the art review of methods guidance from international organisations
Health Technology Assessment of Diagnostic Tests: A state of the art review of methods guidance from international organisations Open
Objectives To identify which international HTA agencies are undertaking evaluations of medical tests, summarise commonalities and differences in methodological approach, and highlight examples of best practice. Methods A methodological rev…
View article: Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation
Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation Open
Recent studies demonstrate that redox imbalance of NAD+/NADH and NADP+/NADPH pairs due to impaired respiration may trigger two "hidden" metabolic pathways on the crossroad between mitochondrial dysfunction, senescence…
View article: Over-Reduced State of Mitochondria as a Trigger of “β-Oxidation Shuttle” in Cancer Cells
Over-Reduced State of Mitochondria as a Trigger of “β-Oxidation Shuttle” in Cancer Cells Open
A considerable amount of data have accumulated in the last decade on the pronounced mitochondrial fatty acid oxidation (mFAO) in many types of cancer cells. As a result, mFAO was found to coexist with abnormally activated fatty acid synthe…
View article: Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State
Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State Open
Glioblastoma is one of the most aggressive brain tumors, characterized by a pronounced redox imbalance, expressed in a high oxidative capacity of cancer cells due to their elevated glycolytic and mitochondrial oxidative metabolism. The ass…
View article: A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer
A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer Open
Cancer metabolism is an extensively studied field since the discovery of the Warburg effect about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has become clear that glycolysis is not the only abnormall…
View article: Effect of Alpha-tocopheryl Succinate on the Cytotoxicity of Anticancer Drugs Towards Leukemia Lymphocytes
Effect of Alpha-tocopheryl Succinate on the Cytotoxicity of Anticancer Drugs Towards Leukemia Lymphocytes Open
α-TS could be a promising adjuvant in second-line anticancer therapy, particularly in acute lymphoblastic leukemia, to reduce the therapeutic doses of barasertib, bortezomib, and lonafarnib, increasing their effectiveness and minimizing th…
View article: It was not easy to identify the study design from the title and abstract of articles indexed as diagnostic (test) accuracy studies in EMBASE in 2012 and 2019
It was not easy to identify the study design from the title and abstract of articles indexed as diagnostic (test) accuracy studies in EMBASE in 2012 and 2019 Open
View article: Redox-modulation, Suppression of “Oncogenic” Superoxide and Induction of Apoptosis in Burkitt’s Lymphoma Cells Using Geum urbanum L. Extracts
Redox-modulation, Suppression of “Oncogenic” Superoxide and Induction of Apoptosis in Burkitt’s Lymphoma Cells Using Geum urbanum L. Extracts Open
Burkitt’s lymphoma is a highly aggressive type of non-Hodgkin’s lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability …
View article: Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug – Comparison With the Chemotherapeutic Standard-of-care Temozolomide
Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug – Comparison With the Chemotherapeutic Standard-of-care Temozolomide Open
M/A differentiates glioblastoma cells from normal microglial cells, causing redox alterations and oxidative stress only in the tumor. This easier-to-tolerate treatment has a potential to support the surgery and conventional therapy of glio…
View article: Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging
Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging Open
Significance: In vivo assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as …
View article: Escalas de ictus prehospitalarias como herramientas de cribado para la identificación precoz del ictus y el accidente isquémico transitorio
Escalas de ictus prehospitalarias como herramientas de cribado para la identificación precoz del ictus y el accidente isquémico transitorio Open
Fundamento.El ictus es una afeccion medica potencialmente mortal en la que se dana el tejido cerebral. La causa puede ser un coagulo que bloquea el suministro de sangre a una parte del cerebro o una hemorragia cerebral. Si los sintomas se …
View article: Symptom scores in the diagnosis of pediatric cow’s milk protein allergy: A systematic review
Symptom scores in the diagnosis of pediatric cow’s milk protein allergy: A systematic review Open
Background Cow's milk protein allergy (CMPA) is an immune‐mediated allergic response to proteins in milk that is common in infants. Broad CMPA symptoms make diagnosis a challenge, particularly in primary care. Symptom scores may improve a …
View article: Author response for "Symptom scores in the diagnosis of pediatric cow's milk protein allergy: A systematic review"
Author response for "Symptom scores in the diagnosis of pediatric cow's milk protein allergy: A systematic review" Open