Zhi-Xiang Shen
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View article: Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial
Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial Open
Background Oliceridine is a novel developed G protein-biased µ-opioid receptor agonist, offering a significant reduction in the risk of opioid-related respiratory depression and a lower incidence of gastrointestinal adverse effects. This s…
View article: Association of systemic immune-inflammatory index with all-cause and cardiovascular mortality among individuals with diabetes: Evidence from the NHANES 2001 to 2018
Association of systemic immune-inflammatory index with all-cause and cardiovascular mortality among individuals with diabetes: Evidence from the NHANES 2001 to 2018 Open
Evidence regarding the systemic immune-inflammatory index (SII) and mortality in patients with diabetes is limited. This study aimed to investigate the relationship of the SII with all-cause and cardiovascular mortality in patients with di…
View article: WATER TEMPERATURE ON GROWTH AND LIPID METABOLISM IN CHINESE MANDARIN FISH
WATER TEMPERATURE ON GROWTH AND LIPID METABOLISM IN CHINESE MANDARIN FISH Open
View article: Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial
Estimation of median effective doses and 95% effective doses of oliceridine combined with propofol for day-case hysteroscopy under total intravenous anesthesia with preserved spontaneous breathing: an up-and-down sequential allocation trial Open
Background Oliceridine is a newly developed G protein-biased µ-opioid receptor agonist, offering a significant reduction in the risk of opioid-related respiratory depression and a lower incidence of gastrointestinal adverse reactions. This…
View article: 大黄素对高温和氧化应激诱导黄颡鱼雄性化的挽救研究
大黄素对高温和氧化应激诱导黄颡鱼雄性化的挽救研究 Open
View article: Cooperation of Experts: Fusing Heterogeneous Information with Large Margin
Cooperation of Experts: Fusing Heterogeneous Information with Large Margin Open
Fusing heterogeneous information remains a persistent challenge in modern data analysis. While significant progress has been made, existing approaches often fail to account for the inherent heterogeneity of object patterns across different…
View article: Multi-Domain Graph Foundation Models: Robust Knowledge Transfer via Topology Alignment
Multi-Domain Graph Foundation Models: Robust Knowledge Transfer via Topology Alignment Open
Recent advances in CV and NLP have inspired researchers to develop general-purpose graph foundation models through pre-training across diverse domains. However, a fundamental challenge arises from the substantial differences in graph topol…
View article: Balanced Multi-Relational Graph Clustering
Balanced Multi-Relational Graph Clustering Open
Multi-relational graph clustering has demonstrated remarkable success in uncovering underlying patterns in complex networks. Representative methods manage to align different views motivated by advances in contrastive learning. Our empirica…
View article: [Cisplatin promotes TNF-α autocrine to trigger RIP1/RIP3/MLKL-dependent necroptosis of human head and neck squamous cell carcinoma cells].
[Cisplatin promotes TNF-α autocrine to trigger RIP1/RIP3/MLKL-dependent necroptosis of human head and neck squamous cell carcinoma cells]. Open
Cisplatin activates nuclear factor-κB signaling in HNSCCs to promote TNF-α autocrine and induce RIP1/RIP3/MLKL-dependent necroptosis, thus leading to inhibition of cell proliferation.
View article: Beyond Redundancy: Information-aware Unsupervised Multiplex Graph Structure Learning
Beyond Redundancy: Information-aware Unsupervised Multiplex Graph Structure Learning Open
Unsupervised Multiplex Graph Learning (UMGL) aims to learn node representations on various edge types without manual labeling. However, existing research overlooks a key factor: the reliability of the graph structure. Real-world data often…
View article: When Heterophily Meets Heterogeneous Graphs: Latent Graphs Guided Unsupervised Representation Learning
When Heterophily Meets Heterogeneous Graphs: Latent Graphs Guided Unsupervised Representation Learning Open
Unsupervised heterogeneous graph representation learning (UHGRL) has gained increasing attention due to its significance in handling practical graphs without labels. However, heterophily has been largely ignored, despite its ubiquitous pre…
View article: CACA guidelines for holistic integrative management of adult acute myeloid leukemia
CACA guidelines for holistic integrative management of adult acute myeloid leukemia Open
The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti- Cancer Association. This portion of the CACA Guidelines for adult acute myeloid leukemia (AML) not only focuses on diagnosis, the treatment options for youn…
View article: Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies Open
Targeted therapy with Bruton tyrosine kinase (BTK) inhibitors have revolutionized the treatment of patients with various B-cell malignancies. BTK inhibitors such as ibrutinib, zanubrutinib, orelabrutinib, and acalabrutinib have shown good …
View article: Clinical observation on the therapeutic efficacy of postoperative GC regimen chemotherapy for upper tract urothelial carcinoma with renal pelvic high-grade and vascular invasion
Clinical observation on the therapeutic efficacy of postoperative GC regimen chemotherapy for upper tract urothelial carcinoma with renal pelvic high-grade and vascular invasion Open
View article: A Multi-Center, Real-World Study of Chidamide for Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas in China
A Multi-Center, Real-World Study of Chidamide for Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas in China Open
Chidamide has demonstrated significant clinical benefits for patients with relapsed/refractory (R/R) PTCL in previous studies. This multi-center observational study was aimed to evaluate the objective response rate (ORR), overall survival …
View article: Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide
Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide Open
View article: Effects of Huaier Extract on Ameliorating Colitis-Associated Colorectal Tumorigenesis in Mice
Effects of Huaier Extract on Ameliorating Colitis-Associated Colorectal Tumorigenesis in Mice Open
Yi-feng Zou,1,2,* Yu-ming Rong,3,* Ze-xian Chen,1,2,* Zhi-hong Shen,4 Xi Chen,1,2 Ying-xin Tan,1,2 Jing-rong Weng,1,2 Xiao-ming Huang,2,5 Xu-tao Lin2,6 1Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen Univers…
View article: Loss of miR-204-5p Promotes Tumor Proliferation, Migration, and Invasion Through Targeting YWHAZ/PI3K/AKT Pathway in Esophageal Squamous Cell Carcinoma
Loss of miR-204-5p Promotes Tumor Proliferation, Migration, and Invasion Through Targeting YWHAZ/PI3K/AKT Pathway in Esophageal Squamous Cell Carcinoma Open
Zhimin Shen,1,* Tianci Chai,1,* Fei Luo,1 Zhun Liu,1 Hui Xu,1 Peipei Zhang,1 Mingqiang Kang,1– 3 Sui Chen1 1Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, People’s Republic of China; 2K…
View article: [Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia].
[Analysis of correlation between plasma trough level and response of generic imatinib in the treatment of Chinese patients with chronic myeloid leukemia]. Open
Objective: To analyze the correlation between plasma trough level of generic imatinib and its metabolism and clinical outcomes in Chinese patients with chronic myeloid leukemia in chronic phase (CML-CP) . Methods: The 21 pati…
View article: An Observational Study of Chinese Adults with Relapsed/Refractory Philadelphia-Negative Acute Lymphoblastic Leukemia
An Observational Study of Chinese Adults with Relapsed/Refractory Philadelphia-Negative Acute Lymphoblastic Leukemia Open
This dataset serves as an important reference of real-world outcomes using currently available chemotherapy regimens for high-risk Chinese adults with relapsed/refractory Ph- ALL.
View article: Association of Thyroid Function With the Estimated Glomerular Filtration Rate in a Large Chinese Euthyroid Population
Association of Thyroid Function With the Estimated Glomerular Filtration Rate in a Large Chinese Euthyroid Population Open
Background/Aims: We aimed to explore whether thyroid function within a normal range is associated with the estimated glomerular filtration rate (eGFR) and the incidence of chronic kidney disease (CKD) in a large Chinese popul…
View article: Cost-Effectiveness Analysis of Chidamide Versus Chemotherapy on The Treatment of Peripheral T - Cell Lymphoma Patients In China
Cost-Effectiveness Analysis of Chidamide Versus Chemotherapy on The Treatment of Peripheral T - Cell Lymphoma Patients In China Open
View article: Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia
Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia Open
Despite advances in the treatment of T‑cell acute lymphoblastic leukemia (T‑ALL), the outcome of T‑ALL treatment remains unsatisfactory, therefore, more effective treatment is urgently required. The present study examined the cytotoxicitie…
View article: The 12-year follow-up of survival, chronic adverse effects, and retention of arsenic in patients with acute promyelocytic leukemia
The 12-year follow-up of survival, chronic adverse effects, and retention of arsenic in patients with acute promyelocytic leukemia Open
To the editor:
Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) have demonstrated notable success in the treatment of acute promyelocytic leukemia (APL).[1][1][⇓][2]-[3][3] However, few studies have reported the adverse effects (…
View article: MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity
MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity Open
MicroRNAs (miRNAs) are short, conserved segments of non-coding RNA which play a significant role in prostate cancer development and progression. To identify miRNAs associated with castration resistance, we performed miRNA microarray analys…
View article: Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia
Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia Open
View article: Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study
Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study Open
View article: Localized primary gastrointestinal diffuse large B cell lymphoma received a surgical approach: an analysis of prognostic factors and comparison of staging systems in 101 patients from a single institution
Localized primary gastrointestinal diffuse large B cell lymphoma received a surgical approach: an analysis of prognostic factors and comparison of staging systems in 101 patients from a single institution Open
View article: [A prospective, multi-centre clinical trial to evaluate the early clinical efficacy and safety of a generic imatinib in treating patients with chronic phase of chronic myelogenous leukemia].
[A prospective, multi-centre clinical trial to evaluate the early clinical efficacy and safety of a generic imatinib in treating patients with chronic phase of chronic myelogenous leukemia]. Open
Our results revealed the excellent early haematology, cytogenetic and molecular responses and safety of Xinwei in treating patients with CML-CP.
View article: Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide
Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide Open