Zhiyong Zou
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View article: Dihydroartemisinin alleviates pulmonary fibrosis by modulating the calcium signaling pathway in fibroblasts
Dihydroartemisinin alleviates pulmonary fibrosis by modulating the calcium signaling pathway in fibroblasts Open
View article: Etiological characteristics of community-acquired bacterial pneumonia in children: A seven-year retrospective, hospital-based study
Etiological characteristics of community-acquired bacterial pneumonia in children: A seven-year retrospective, hospital-based study Open
View article: Different therapeutic responses to osimertinib as first-line treatment for cavitated and non-cavitated squamous cell lung cancer with rare EGFR exon 19 deletion: two case reports and a literature review
Different therapeutic responses to osimertinib as first-line treatment for cavitated and non-cavitated squamous cell lung cancer with rare EGFR exon 19 deletion: two case reports and a literature review Open
Background Cavitation is a special radiological feature of lung cancer, commonly observed in squamous cell lung cancer (SqCLC). This study intended to report two cases of cavitated and non-cavitated SqCLCs treated with epidermal growth fac…
View article: Genome-Wide Analysis of DNA Methylation Signatures Linking Prenatal Exposure to the Chinese Great Famine and Blood Lipids in Late Adulthood: The Genomic Research of the Chinese Famine (GRECF) Study
Genome-Wide Analysis of DNA Methylation Signatures Linking Prenatal Exposure to the Chinese Great Famine and Blood Lipids in Late Adulthood: The Genomic Research of the Chinese Famine (GRECF) Study Open
Background/Objectives: Prenatal exposure to famine can lead to lasting health effects through changes in DNA methylation. This study aims to evaluate the impact of prenatal exposure to the Chinses Great Famine (1959–1961) on human epigenom…
View article: Clinical study on the intervention of <italic>Jiawei Yangjing Zhongyu Decoction</italic>（加味养精种玉汤）in patients with moderate intrauterine adhesion of kidney deficiency and blood stasis after TCRA surgery
Clinical study on the intervention of <italic>Jiawei Yangjing Zhongyu Decoction</italic>（加味养精种玉汤）in patients with moderate intrauterine adhesion of kidney deficiency and blood stasis after TCRA surgery Open
View article: M1-Derived Migrasome Ameliorate Temporomandibular Joint Osteoarthritis Via Autophagy Activation
M1-Derived Migrasome Ameliorate Temporomandibular Joint Osteoarthritis Via Autophagy Activation Open
Aim or purpose: Emerging evidence highlights migrasomes as critical mediators of intercellular communication through their ability to shuttle bioactive cargo—including signaling molecules, proteases, and genetic material. Considering that …
View article: High speed and low complexity OFDM terahertz wireless communication baseband system
High speed and low complexity OFDM terahertz wireless communication baseband system Open
The terahertz (THz) band (0.1 – 10 THz) is envisioned as a cornerstone for future 6G wireless communication systems. However, due to the performance limitations of baseband components, current THz communication baseband systems face persis…
View article: Global, regional, and national time trends in prevalence of metabolic dysfunction associated steatotic liver disease among women of reproductive age: an age-period-cohort analysis for the global Burden of Disease 2021 study
Global, regional, and national time trends in prevalence of metabolic dysfunction associated steatotic liver disease among women of reproductive age: an age-period-cohort analysis for the global Burden of Disease 2021 study Open
MASLD in the WRA is an increasing health problem in all countries, and is accompanied by worsening period and cohort risks. These population-level trends warrant further investigation of their clinical implications for maternal health outc…
View article: Imbalance between muscle strength development and weight gain in children and young adults in China: serial cross-sectional evidence from 1.33 million students from five successive national surveys between 2000 and 2019
Imbalance between muscle strength development and weight gain in children and young adults in China: serial cross-sectional evidence from 1.33 million students from five successive national surveys between 2000 and 2019 Open
View article: Structural characteristics, multifunctional applications, and research prospects of ferritin: a case study of sturgeon ferritin
Structural characteristics, multifunctional applications, and research prospects of ferritin: a case study of sturgeon ferritin Open
Ferritin is a ubiquitous cage-shaped protein found in living organisms. Beyond its fundamental role in iron homeostasis, ferritin demonstrates growing application value in food engineering, nanocarrier systems, and biomedicine, owing to it…
View article: Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition
Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition Open
Rhythm perception is considered a conserved trait across species, and musical rhythm exposure (MRE) has been demonstrated to enhance cognitive functions in healthy individuals. Alzheimer's disease (AD), characterized by cognitive decline a…
View article: Unraveling the relationships of phthalate exposure, long-term trajectories for novel insulin resistance biomarkers and accelerated pubertal onset in children
Unraveling the relationships of phthalate exposure, long-term trajectories for novel insulin resistance biomarkers and accelerated pubertal onset in children Open
Phthalates (PAEs) exposure and triglyceride-glucose (TyG) index-an indicator of insulin resistance (IR), remains not fully understood. To investigate the predictive and mediating role of IR markers in associations between PAEs exposure and…
View article: Burden and risk factors of premature drowning mortality in 204 countries and territories, 1980–2021
Burden and risk factors of premature drowning mortality in 204 countries and territories, 1980–2021 Open
View article: Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles
Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles Open
Postoperative cognitive dysfunction is a common central nervous system complication after general anesthesia in the elderly, and when it occurs, it will seriously affect the patient’s postoperative recovery and quality of life, which puts …
View article: What are the optimal mind-body therapies for cancer-related pain? A network meta-analysis
What are the optimal mind-body therapies for cancer-related pain? A network meta-analysis Open
Introduction Current international guidelines encourage cancer patients to engage in physical activity and recommend mind-body therapies (MBTs) as a method for treating cancer-related pain (CRP). However, the most effective MBTs for improv…
View article: Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021
Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021 Open
Aims The prevalence of heart failure (HF) continues to rise with a growing impact on younger populations, while epidemiological comprehensive data on HF in adolescents and young adults remain scarce. This study aimed to report population s…
View article: Maternal Exposure to Ambient Ozone and Fetal Critical Congenital Heart Disease in China: A Large Multicenter Retrospective Cohort Study
Maternal Exposure to Ambient Ozone and Fetal Critical Congenital Heart Disease in China: A Large Multicenter Retrospective Cohort Study Open
The relevance of O3 exposure in critical congenital heart disease (CCHD) remains uncertain and requires further investigation. The present study aims at quantitatively assessing the association between ambient O3 exposure during the early …
View article: Trends and Inequities in the Burden of Depressive Disorders Among Adolescents and Young Adults in the Western Pacific, 1990–2021: Findings from the Global Burden of Disease Study, 2021
Trends and Inequities in the Burden of Depressive Disorders Among Adolescents and Young Adults in the Western Pacific, 1990–2021: Findings from the Global Burden of Disease Study, 2021 Open
Despite growing concern, there is limited comprehensive and up-to-date research on the burden, disparities, and inequalities of depressive disorders in the Western Pacific region. We obtained data from the Global Burden of Disease Study (G…
View article: The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study
The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study Open
Pulmonary arterial hypertension (PAH) poses significant clinical management challenges due to gaps in understanding its global epidemiology. We analyzed PAH‐related disability‐adjusted life years (DALYs), deaths, and prevalence from 1990 t…
View article: Importance of cohort and target trial emulation in clinical research
Importance of cohort and target trial emulation in clinical research Open
Advances in cohort studies and target trial emulation provide substantial evidence for policymaking to enhance global health. Moving forward, key priorities should focus on standardizing data processing protocols, advancing life-course res…
View article: XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity
XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity Open
BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited. Intramyocardial lipotoxic…
View article: Tobacco and alcohol use; suicide ideation, plan, and attempt among adolescents; and the role of legal purchase age restrictions: a pooled population-based analysis from 58 countries
Tobacco and alcohol use; suicide ideation, plan, and attempt among adolescents; and the role of legal purchase age restrictions: a pooled population-based analysis from 58 countries Open
Tobacco and alcohol consumption are strongly associated with the risk of suicide behaviors among adolescents, particularly among girls. Country-level tobacco control strategies may have the potential to reduce risks of suicide behaviors as…
View article: Diagnosis-related groups study of uterine leiomyoma patients based on E-CHAID
Diagnosis-related groups study of uterine leiomyoma patients based on E-CHAID Open
Diagnosis-related groups (DRG) is emerging as an effective tool for measuring the quality and efficiency of medical services. This study aims to explore a DRG combination scheme for control the hospitalization costs in patients with uterin…
View article: Association between visceral fat area and metabolic syndrome in individuals with normal body weight: insights from a Chinese health screening dataset
Association between visceral fat area and metabolic syndrome in individuals with normal body weight: insights from a Chinese health screening dataset Open
Background Metabolic syndrome (MetS) is increasingly diagnosed in individuals with normal body weight, and visceral fat emerges as a significant risk factor. However, the relationship between visceral fat area (VFA) and MetS within this po…
View article: Low-density lipoprotein cholesterol predicts coronary artery calcification events in patients with type 2 diabetes: a longitudinal study
Low-density lipoprotein cholesterol predicts coronary artery calcification events in patients with type 2 diabetes: a longitudinal study Open
View article: Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China
Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China Open
In individuals with prediabetes, a higher LFC is associated with an elevated risk of hyperuricemia, especially when LFC exceeds 8.4%.
View article: Research Progress on the Formation Mechanism and DNA Methylation of Autologous Arteriovenous Fistula Stenosis
Research Progress on the Formation Mechanism and DNA Methylation of Autologous Arteriovenous Fistula Stenosis Open
Arteriovenous fistula (AVF), as the most commonly used vascular pathway for end-stage renal failure hemodialysis patients, is also the premise for hemodialysis patients to start and maintain dialysis, but its complications have become the …
View article: The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease study 2021
The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease study 2021 Open
Background Low physical activity (LPA) is a leading risk factor for type 2 diabetes mellitus (T2DM). We examine the temporal and spatial trends in the burden of T2DM attributable to LPA at the global, regional, and country scales. Methods …
View article: A study on predicting malnutrition risk in Parkinson’s disease patients using a nomogram model
A study on predicting malnutrition risk in Parkinson’s disease patients using a nomogram model Open
View article: Lactobacillales Improves Insomnia and Restores Metabolic-Neurotransmitter Profiles Via Gut Microbiota in Pcpa-Induced Mice
Lactobacillales Improves Insomnia and Restores Metabolic-Neurotransmitter Profiles Via Gut Microbiota in Pcpa-Induced Mice Open