Zhixiao Sun
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View article: Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning
Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning Open
The Catboost model has the most advantages and can be used for clinical evaluation and patient monitoring.
View article: Breaking new ground: machine learning enhances survival forecasts in hypercapnic respiratory failure
Breaking new ground: machine learning enhances survival forecasts in hypercapnic respiratory failure Open
Background The prognostic prediction of patients with hypercapnic respiratory failure holds significant clinical value. The objective of this study was to develop and validate a predictive model for predicting survival in patients with hyp…
View article: A novel microRNA miR-4433a-3p as a potential diagnostic biomarker for lung adenocarcinoma
A novel microRNA miR-4433a-3p as a potential diagnostic biomarker for lung adenocarcinoma Open
miR-4433a-3p may serve as a biomarker for the early diagnosis of lung adenocarcinoma and monitoring of therapeutic effects.
View article: Development and validation of a prospective study to predict the risk of readmission within 365 days of respiratory failure: based on a random survival forest algorithm combined with COX regression modeling
Development and validation of a prospective study to predict the risk of readmission within 365 days of respiratory failure: based on a random survival forest algorithm combined with COX regression modeling Open
Background There is a need to develop and validate a widely applicable nomogram for predicting readmission of respiratory failure patients within 365 days. Methods We recruited patients with respiratory failure at the First People’s Hospit…
View article: LincR-PPP2R5C Promotes Th2 Cell Differentiation Through PPP2R5C/PP2A by Forming an RNA–DNA Triplex in Allergic Asthma
LincR-PPP2R5C Promotes Th2 Cell Differentiation Through PPP2R5C/PP2A by Forming an RNA–DNA Triplex in Allergic Asthma Open
LincR-PPP2R5C regulated PPP2R5C expression and PP2A activity by forming an RNA-DNA triplex with the PPP2R5C promoter, leading to Th2 polarization in a mouse model of acute asthma. Our data presented the first definitive evidence of lncRNAs…
View article: Fine Particulate Matter (PM2.5) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection
Fine Particulate Matter (PM2.5) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection Open
Air pollution is a leading cause of increasing infectious lung diseases. Pulmonary cryptococcosis is a fatal fungal pneumonia in acquired immunodeficiency syndrome patients. In some cases, the pathogen Cryptococcus neoformans also develops…
View article: IL‐33/ST2 axis deficiency exacerbates neutrophil‐dominant allergic airway inflammation
IL‐33/ST2 axis deficiency exacerbates neutrophil‐dominant allergic airway inflammation Open
Objective The IL‐33/ST2 axis has been extensively investigated in type 2 eosinophilic inflammation. Here, we aimed to investigate the role of the IL‐33/ST2 axis in neutrophil‐dominant allergic airway inflammation. Methods House‐dust mite (…
View article: Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis
Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis Open
Epithelial-mesenchymal transition (EMT) is essential in asthma airway remodeling. IL-33 from epithelial cells is involved in pulmonary fibrosis. CD146 has been extensively explored in cancer-associated EMT. Whether IL-33 regulates CD146 in…
View article: Airway invasive aspergillosis with organizing pneumonia: a case report and review of literature
Airway invasive aspergillosis with organizing pneumonia: a case report and review of literature Open
Organizing pneumonia (OP) is a distinct clinical and pathologic entity. This condition can be cryptogenic (COP) or secondary to other known causes (secondary OP, SOP). Concomitant occurrence of invasive pulmonary aspergillosis (IPA) with S…
View article: MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation Open
MiR-1165-3p negatively may regulate Th2-cell differentiation by targeting IL-13 and PPM1A in allergic airway inflammation.
View article: Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels
Downregulation of miR-4772-3p promotes enhanced regulatory T cell capacity in malignant pleural effusion by elevating Helios levels Open
Downregulation of miR-4772-3p, by targeting Helios, contributes to enhanced Tregs activities in the MPE microenvironment.
View article: Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection Open
Pulmonary edema is a fatal complication of EV71-associated hand, foot, and mouth disease (HFMD). The pathogenesis of EV71-induced pulmonary edema remains largely unclear. In this study, we aimed to explore the roles of the capsid protein V…
View article: Increased neutrophils and IL-17A in a rare organizing pneumonia secondary to extrapulmonary operation
Increased neutrophils and IL-17A in a rare organizing pneumonia secondary to extrapulmonary operation Open
Organizing pneumonia (OP) is a clinical syndrome caused by various diseases. The most common causes are infection, connective tissue disease, radiation therapy, drug reaction and thoracic operation. Herein, we describe the case of a patien…
View article: Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma
Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma Open
This study provided the first evidence for different expression of lncRNAs of CD4+T cells in asthma and may serve as a template for further, larger functional in-depth analyses regarding asthma molecular lncRNAs.
View article: A novel microRNA miR-1165-3p as a potential diagnostic biomarker for allergic asthma
A novel microRNA miR-1165-3p as a potential diagnostic biomarker for allergic asthma Open
Context: A further examination of a novel miRNA,miR-1165-3p as a biomarker for asthma, which was previously implicated in helper T cells (Th2) in a murine asthma model. Objective: To determine whether serum miR-1165-3p can serve as a poten…
View article: Next Generation Sequencing for miRNA Profile of Spleen CD4 <sup>+</sup> T Cells in the Murine Model of Acute Asthma
Next Generation Sequencing for miRNA Profile of Spleen CD4 <sup>+</sup> T Cells in the Murine Model of Acute Asthma Open
Aberrant miRNAs profile in the CD4+ T lymphocytes from acute asthma was documented.