Zhihong Sun
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View article: Microvillus in LBW Meishan Piglets Preserved Microvillus Integrity Alongside Impaired Intestinal Barrier Function in Low-Birth-Weight Meishan Neonatal Piglets
Microvillus in LBW Meishan Piglets Preserved Microvillus Integrity Alongside Impaired Intestinal Barrier Function in Low-Birth-Weight Meishan Neonatal Piglets Open
Despite lower birth weight, Meishan piglets exhibit a notably higher pre-weaning survival rate compared to Western commercial breeds. This study aimed to evaluate the effect of low birth weight (LBW) on intestinal barrier function in Meish…
View article: A novel LAMP2 initiation codon mutation causes Danon Disease: a case report
A novel LAMP2 initiation codon mutation causes Danon Disease: a case report Open
Danon Disease (DD) is a rare X-linked inherited disorder caused by severe deficiency of lysosome-associated membrane protein-2 (LAMP-2), encoded by the LAMP2 gene. Characteristic clinical features include a triad of cardiomyopathy, skeleta…
View article: Effects of 25-hydroxyvitamin D3, chondroitin sulfate and glucosamine sulfate on the growth performance, calcium and phosphorus metabolism, and bone development of weaned piglets
Effects of 25-hydroxyvitamin D3, chondroitin sulfate and glucosamine sulfate on the growth performance, calcium and phosphorus metabolism, and bone development of weaned piglets Open
This study aimed to determine the effects of 25-hydroxyvitamin D3 (25-OH-VD3), combined with chondroitin sulfate (CS) and glucosamine sulfate (GS), on calcium and phosphorus metabolism and bone development of weaned piglets. One hundred we…
View article: Genome-wide identification and expression analysis of the PsKIN gene family in pea
Genome-wide identification and expression analysis of the PsKIN gene family in pea Open
Peas ( Pisum sativum L.) serve as a vital model for plant development and stress research. The kinesin ( KIN ) gene family, encoding essential motor proteins, remains understudied in peas. Our research conducted a comprehensive genomic ana…
View article: Genome-Wide Identification and Expression Analysis of the PsTPS Gene Family in Pisum sativum
Genome-Wide Identification and Expression Analysis of the PsTPS Gene Family in Pisum sativum Open
This study aimed to explore the role of the trehalose-6-phosphate synthase (TPS) gene family in the adaptation of peas to environmental stress. A comprehensive analysis of the PsTPS gene family identified 20 genes with conserved domains an…
View article: Sex‐based immune microenvironmental feature heterogeneity in response to <scp>PD</scp>‐1 blockade in combination with chemotherapy for patients with untreated advanced non‐small‐cell lung cancer
Sex‐based immune microenvironmental feature heterogeneity in response to <span>PD</span>‐1 blockade in combination with chemotherapy for patients with untreated advanced non‐small‐cell lung cancer Open
Background To investigate the sex‐based heterogeneity of immune microenvironmental feature and its impact on the response to first‐line PD‐1 blockade plus chemotherapy in patients with driver‐negative advanced or metastatic non‐small‐cell …
View article: Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds
Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds Open
Post-weaning diarrhea (PWD) is a globally significant threat to the swine industry. Historically, antibiotics as well as high doses of zinc oxide and copper sulfate have been commonly used to control PWD. However, the development of bacter…
View article: Influence of fabric permeability on breathing phenomenon of supersonic parachute
Influence of fabric permeability on breathing phenomenon of supersonic parachute Open
In order to investigate the dynamics and vortex shedding of flexible supersonic canopies, a compressible permeability model combined with fabric structure parameters is proposed, and the periodic oscillation of the supersonic parachute whi…
View article: Effects of Dietary Protein Levels on Fecal Amino Acids Excretion and Apparent Digestibility, and Fecal and Ileal Microbial Amino Acids Composition in Weaned Piglets
Effects of Dietary Protein Levels on Fecal Amino Acids Excretion and Apparent Digestibility, and Fecal and Ileal Microbial Amino Acids Composition in Weaned Piglets Open
Background and Aims: The purpose of this study was to determine the effects of low protein diets with the same Lys, Met + Cys, Thr, and Trp levels as in high protein diets on the fecal amino acid excretion and apparent digestibility, and i…
View article: Effects of supplementing low-protein diets with sodium dichloroacetate and glucose on growth performance, carcass traits, and meat quality of growing-finishing pigs
Effects of supplementing low-protein diets with sodium dichloroacetate and glucose on growth performance, carcass traits, and meat quality of growing-finishing pigs Open
The objective of this study was to evaluate the effects of supplementing low-protein diets with sodium dichloroacetate (DCA) and glucose on growth performance, carcass traits, and meat quality of growing-finishing pigs. A total of 80 cross…
View article: Breast surgery for young women with early-stage breast cancer
Breast surgery for young women with early-stage breast cancer Open
Whether breast-conserving therapy (BCT) should be chosen as a local treatment for young women with early-stage breast cancer is controversial. This study compared the survival benefits of BCT or mastectomy in young women under 40 with earl…
View article: Comparison of the ductal carcinoma in situ between White Americans and Chinese Americans
Comparison of the ductal carcinoma in situ between White Americans and Chinese Americans Open
Currently, the wide-spread use of screening mammography has led to dramatic increases in ductal carcinoma in situ (DCIS). However, DCIS of Chinese Americans, the largest Asian subgroup in American, has rarely been comprehensively studied o…
View article: Both sampling seasonality and geographic origin contribute significantly to variations in raw milk microbiota, but sampling seasonality is the more determining factor
Both sampling seasonality and geographic origin contribute significantly to variations in raw milk microbiota, but sampling seasonality is the more determining factor Open
The current work was an observational study aiming to profile the microbiota of raw milk collected across wide geographic regions in China in different seasons and to investigate the contribution of geographical, seasonal, and environmenta…
View article: The effect of anticancer treatment on cancer patients with COVID‐19: A systematic review and meta‐analysis
The effect of anticancer treatment on cancer patients with COVID‐19: A systematic review and meta‐analysis Open
Background The relationship between cancer and COVID‐19 has been revealed during the pandemic. Some anticancer treatments have been reported to have negative influences on COVID‐19‐infected patients while other studies did not support this…
View article: The complete mitogenome sequence of the coral lily (Lilium pumilum) and the Lanzhou lily (Lilium davidii) in China
The complete mitogenome sequence of the coral lily (Lilium pumilum) and the Lanzhou lily (Lilium davidii) in China Open
Background The mitogenomes of higher plants are conserved. This study was performed to complete the mitogenome of two China Lilium species ( Lilium pumilum Redouté and Lilium davidii var. unicolor (Hoog) cotton). Methods Genomic DNA was se…
View article: Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy
Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy Open
Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these for…
View article: Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health
Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health Open
In recent years, many studies have shown that the intestinal microflora has various effects that are linked to the critical physiological functions and pathological systems of the host. The intestinal microbial community is widely involved…
View article: NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy
NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy Open
Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal th…
View article: NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy
NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy Open
Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal th…
View article: NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy
NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy Open
Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal th…
View article: Natural Killer Cell Inspired AIE Nanoterminator for Blood-Brain-Barrier Crossing via Tight-Junction Modulation and NIR-II Gliomas Theranostics
Natural Killer Cell Inspired AIE Nanoterminator for Blood-Brain-Barrier Crossing via Tight-Junction Modulation and NIR-II Gliomas Theranostics Open
Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. In this paper, we developed a natural killer cell-mimic AIE nanoterminator (NK@AIEdots) by coa…
View article: Tryptophan promoted β-defensin-2 expression<i>via</i>the mTOR pathway and its metabolites: kynurenine banding to aryl hydrocarbon receptor in rat intestine
Tryptophan promoted β-defensin-2 expression<i>via</i>the mTOR pathway and its metabolites: kynurenine banding to aryl hydrocarbon receptor in rat intestine Open
In this study, we investigated the signalling pathways mediating tryptophan (Trp)-promoted β-defensin-2 (BD-2) expression in rat intestinal mucosa.