Explanipedia

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives Open

Chao Lei, Di Wu, Houyan Zhang, Zhiya Yang, Bohao Huang , et al. · 2025

Organ fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function. While canonical inflammatory and profibrotic cascades ha…

Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report Open

L. Wang, Yahui Feng, Sisi Wang, Leyao Shi, Yong Ren , et al. · 2025

Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agent…

Galleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates Open

Dongmei Shi, Zhiya Yang, Wanqing Liao, Chen Liu, Liang Zhao , et al. · 2024

Background Chromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii ( C. carrionii ) is one of the agents. However, the pathoge…

Effects of secukinumab and ixekizumab on major adverse cardiovascular events in patients with psoriasis: a meta-analysis of randomized controlled trials Open

Yonghong Zhang, Zhiya Yang, Jinyan Gong, Dongmei Shi · 2024

Introduction The aims of this study is to analyze the risk of major adverse cardiovascular events (MACEs) in patients with psoriasis treated with secukinumab and ixekizumab. Methodology We systematically identified randomized controlled tr…

Virulence capacity of different Aspergillus species from invasive pulmonary aspergillosis Open

Biao Chen, Guocheng Qian, Zhiya Yang, Ning Zhang, Yufeng Jiang , et al. · 2023

Introduction The opportunistic filamentous fungus Aspergillus causes invasive pulmonary aspergillosis (IPA) that often turns into a fatal infection in immunocompromised hosts. However, the virulence capacity of different Aspergillus specie…

Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis Open

Junfeng Zhang, Yunsheng Zhang, Zhiya Yang, Dalei Cheng, Hui Zhang , et al. · 2023

Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood. In the present study, we demonstrated that the expression of the anti-i…

Correlation Between Drug Resistance and Virulence of Candida Isolates from Patients with Candidiasis Open

Zhiya Yang, Fangfang Zhang, Dongmei Li, Sisi Wang, Zhiping P. Pang , et al. · 2022

The possibility of Candida infection should not be neglected in patients at critical care hospital settings and C. albicans is the most common causative agent. MALDI-TOF MS has the advantages of rapidity and high accuracy, an…

Distinct host immune responses in recurrent vulvovaginal candidiasis and vulvovaginal candidiasis Open

Gai Ge, Zhiya Yang, Dongmei Li, Ning Zhang, Biao Chen , et al. · 2022

Recurrent vulvovaginal candidiasis (RVVC) and vulvovaginal candidiasis (RVVC) are one of the most common gynecological infections, primarily caused by Candida species. Although risk factors of RVVC and VVC have been identified in many stud…

IL-35 ameliorates psoriasis by suppressing the accumulation of iNOS-expressing myeloid-derived suppressor cells Open

Junfeng Zhang, Yunsheng Zhang, Zhiya Yang, Dalei Cheng, Hui Zhang , et al. · 2022

Background and Purpose: Psoriasis is an immune-associated disease, however, the pathogenesis of psoriasis remains unclear. We investigated the mechanism of IL-35 in psoriasis treatment. Experimental Approach: PASI and Baker scores were use…

Presence of <i>Malassezia</i> Hyphae Is Correlated with Pathogenesis of Seborrheic Dermatitis Open

Juanjuan Li, Yahui Feng, Chen Liu, Zhiya Yang, Sybren de Hoog , et al. · 2022

Our results support the proposal that the hyphal form of Malassezia could be one of the pathogenic factors that contribute to SD, which has been previously less well studied. This clinical observation paves the way for further investigatio…

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant <i>Mycobacterium marinum</i> Open

Zhiya Yang, Yahui Feng, Zhiping P. Pang, Dongmei Li, Sisi Wang , et al. · 2021

Background Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has been extensively used to treat to various skin disease, the application of ALA-PDT on cutaneous infection caused by Mycobacterium marinum ( M. marinum ), especial…

Evaluation of Droplet Digital PCR Assay for the Diagnosis of Candidemia in Blood Samples Open

Biao Chen, Xie Ying-guang, Ning Zhang, Wenqiang Li, Chen Liu , et al. · 2021

Numerous studies have shown that droplet digital PCR (ddPCR) is a promising tool for the diagnosis of pathogens, especially in samples with low concentrations of pathogenic DNA. An early diagnosis of candidemia is critical for the effectiv…

THE DIFFERENT INTERPRETATIONS OF GORKY’S THOUGHTS IN CHINESE LITERATURE OF THE 1930s Open

Zhiya Yang · 2021

Joseph Stalin, as the ruler of the USSR, invited Maxim Gorky (who was living in Europe at that time) to return home to preach and consolidate socialist realism, and so socialist realism was established in Russia in the 1930s. Gorky played …

Onychomycosis with greenish-black discolorations and recurrent onycholysis caused by Candida parapsilosis Open

Gai Ge, Zhiya Yang, Dongmei Li, G. Sybren de Hoog, Dongmei Shi · 2019

Candida parapsilosis (C. parapsilosis) has become a common pathogen, especially in immunocompromised hosts. Here, we present an immunocompetent adult with greenish-black discoloration of the right first finger nail in combina…

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