Zhiyan Liang
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View article: Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research
Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research Open
Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) are generally resistant to targeted therapy with tyrosine kinase inhibitors (TKIs), such as imatinib, and there are no standard therapeutic options for advance…
View article: Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies
Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies Open
Introduction Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have poor prognoses. Venetoclax plus hypomethylating agent AZA is approved for certain patients with AML, but most have resistance or intolerance, warranting add…
View article: Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis Open
Introduction Neuroprotective agents for acute ischemic stroke often fall short in efficacy due to the blood–brain barrier challenges, lack of target specificity, and limited effectiveness. Recently, plant-derived extracellular vesicle-like…
View article: Mass Transfer‐Enhanced Photothermal Membranes with Synergistic Light Utilization for High‐Turbidity Wastewater Purification
Mass Transfer‐Enhanced Photothermal Membranes with Synergistic Light Utilization for High‐Turbidity Wastewater Purification Open
The photo‐Fenton process faces significant limitations in treating high‐turbidity, colored wastewater due to light attenuation and impurity interference (blocked mass transfer). To address these issues, we developed a suspended phototherma…
View article: Mass Transfer‐Enhanced Photothermal Membranes with Synergistic Light Utilization for High‐Turbidity Wastewater Purification
Mass Transfer‐Enhanced Photothermal Membranes with Synergistic Light Utilization for High‐Turbidity Wastewater Purification Open
The photo‐Fenton process faces significant limitations in treating high‐turbidity, colored wastewater due to light attenuation and impurity interference (blocked mass transfer). To address these issues, we developed a suspended phototherma…
View article: APG-2449, a Novel Focal Adhesion Kinase (FAK) Inhibitor, Exhibits Antileukemic Activity and Enhances Lisaftoclax (APG-2575)-Induced Apoptosis in Acute Myeloid Leukemia (AML)
APG-2449, a Novel Focal Adhesion Kinase (FAK) Inhibitor, Exhibits Antileukemic Activity and Enhances Lisaftoclax (APG-2575)-Induced Apoptosis in Acute Myeloid Leukemia (AML) Open
Introduction High FAK expression is associated with increased blast proliferation and poor prognosis in AML. Preclinical and clinical studies have demonstrated that selective targeting of BCL-2 has broad antitumor activities against hemato…
View article: Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway
Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway Open
Hemorrhagic transformation (HT) and restrictive therapeutic time window are significant limitations of delayed t-PA (tissue-type plasminogen activator) thrombolytic therapy in ischemic stroke patients. Plant Momordica charantia-derived exo…
View article: Effective green treatment of sewage sludge from Fenton reactions: Utilizing MoS <sub>2</sub> for sustainable resource recovery
Effective green treatment of sewage sludge from Fenton reactions: Utilizing MoS <sub>2</sub> for sustainable resource recovery Open
Effectively managing sewage sludge from Fenton reactions in an eco-friendly way is vital for Fenton technology’s viability in pollution treatment. This study focuses on sewage sludge across various treatment stages, including generation, c…
View article: Dynamic defects boost in-situ H <sub>2</sub> O <sub>2</sub> piezocatalysis for water cleanup
Dynamic defects boost in-situ H <sub>2</sub> O <sub>2</sub> piezocatalysis for water cleanup Open
Creating efficient catalysts for simultaneous H 2 O 2 generation and pollutant degradation is vital. Piezocatalytic H 2 O 2 synthesis offers a promising alternative to traditional methods but faces challenges like sacrificial reagents, har…
View article: Serological surveillance of GI norovirus reveals persistence of blockade antibody in a Jidong community-based prospective cohort, 2014–2018
Serological surveillance of GI norovirus reveals persistence of blockade antibody in a Jidong community-based prospective cohort, 2014–2018 Open
Introduction Herd immunity against norovirus (NoV) is poorly understood in terms of its serological properties and vaccine designs. The precise neutralizing serological features of genotype I (GI) NoV have not been studied. Methods To expa…
View article: Development and evaluation of a new luciferase immunosorbent assay to detect GII.6 norovirus-specific IgG in different domestic and wild animals
Development and evaluation of a new luciferase immunosorbent assay to detect GII.6 norovirus-specific IgG in different domestic and wild animals Open
Noroviruses (NoVs) are the leading viral pathogens globally causing acute gastroenteritis (AGE) in humans, posing a significant global health threat and economic burden. Recent investigations revealed that human NoVs had been detected in d…
View article: Single-atom Mo–Co catalyst with low biotoxicity for sustainable degradation of high-ionization-potential organic pollutants
Single-atom Mo–Co catalyst with low biotoxicity for sustainable degradation of high-ionization-potential organic pollutants Open
Single-atom catalysts (SACs) are a promising area in environmental catalysis. We report on a bimetallic Co–Mo SAC that shows excellent performance in activating peroxymonosulfate (PMS) for sustainable degradation of organic pollutants with…